Metpure-XL 25 Tablet is used alone or together with other medicines to treat high blood pressure (hypertension), heart-related chest pain (angina), and heart rhythm disorder (arrhythmia). Besides this, it also helps in relieving symptoms of migraine-related headaches. High blood pressure adds to the workload of the heart and arteries. Hypertension or high blood pressure is a long-term force of the blood against the arteries that may lead to various types of heart diseases. If it continues for a long time, it can damage the blood vessels (arteries) of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure reduces the risk of stroke, heart attack, and heart-related chest pain (angina).

Metpure-XL 25 Tablet contains S Metoprolol Succinate. It plays a vital role in relaxing our blood vessels by blocking the action of certain natural substances in your body. It helps slow down the heart rate, making it easier to pump more blood around your body. This lowers your blood pressure and helps reduce your risk of a stroke, a heart attack, other heart problems, or kidney problems in the future. Metpure-XL 25 Tablet needs to be taken regularly to be effective.

Metpure-XL 25 Tablet should be taken in the dose and duration your doctor advises. You are advised to take Metpure-XL 25 Tablet for as long as your doctor has prescribed, depending on your medical condition. In some cases, you may experience common side effects such as headache, fatigue, nausea, vomiting, stomach upset, diarrhoea or constipation, abdominal pain, numbness, and cold extremities. Most of these side effects of Metpure-XL 25 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. However, you are advised to talk to your doctor if you experience these side effects persistently.

Don't stop taking Metpure-XL 25 Tablet without consulting your doctor first. Stopping Metpure-XL 25 Tablet abruptly may cause changes in your heart rhythm and blood pressure, cause chest pain, or a heart attack. Your doctor will gradually lower your dose over time to help prevent these symptoms. Metpure-XL 25 Tablet should not be used to prevent heart attacks. You should not use Metpure-XL 25 Tablet if you have a very slow heartbeat, asthma, serious heart condition (sick sinus syndrome), or any heart blockage. Pregnant and breastfeeding women should consult the doctor before taking the Metpure-XL 25 Tablet . Driving and operating heavy machinery should not be done as it may cause dizziness and drowsiness.  Orthostatic hypotension (sudden lowering of blood pressure while standing) might occur, so patients using Metpure-XL 25 Tablet should get up with caution. Metpure-XL 25 Tablet is contraindicated if you have high amounts of potassium in your blood (shown in blood test results). Metpure-XL 25 Tablet may affect your ability to drive or operate heavy machinery if taken with alcohol.

Metpure-XL 25 Tablet contains S Metoprolol Succinate belongs to a group of medicines called beta-blockers used to treat high blood pressure (hypertension), heart-related chest pain (angina), irregular heart rhythm (arrhythmia), and to protect the heart after a heart attack (myocardial infarction). Besides this, it also helps relieve symptoms of migraine-related headaches. Metpure-XL 25 Tablet  helps slow down the heart rate, making it easier for the heart to pump blood throughout the body. This lowers blood pressure and helps in reducing the risk of having a stroke, heart attack, or other heart or kidney problems in the future. 

• Headache

• Fatigue
• Nausea
• Vomiting
• Stomach upset
• Diarrhoea
• Constipation
• Abdominal pain
• Numbness
• Cold extremities
• Slow heart rate
• Breathlessness

Do not take Metpure-XL 25 Tablet if you are allergic (hypersensitive) to the Metpure-XL 25 Tablet or any ingredients present. Please consult your doctor before taking Metpure-XL 25 Tablet if you are pregnant or planning to conceive and breastfeed. It should not be given to children less than 12 years of age. Don't stop taking Metpure-XL 25 Tablet without talking to your doctor first. Stopping Metpure-XL 25 Tablet gradually may cause changes in your heart rhythm and blood pressure, cause chest pain, or a heart attack. Your doctor will lower your dose gradually over some time to help prevent these symptoms. You should not use the Metpure-XL 25 Tablet if you have a very slow heartbeat, a serious lung condition (like asthma), a serious heart condition (sick sinus syndrome), or a heart blockage. Before taking this medicine, you should tell the doctor if you have any muscle disorder (myasthenia gravis, rhabdomyolysis), breathing problems (COPD, bronchitis, emphysema), low blood sugar level (hypoglycemia), low blood pressure (hypotension), depression, previous heart failure, liver/kidney disease, thyroid hormone disorder like overactive thyroid (hyperthyroidism), adrenal gland cancer, or severe blood circulation problem (Raynaud's syndrome).

Drug-Drug Interactions: Metpure-XL 25 Tablet may interact with antihypertensive agents (e.g. clonidine, diltiazem), certain cancer medications (e.g. ceritinib, dolasetron), medicines used to treat irregular heartbeat (e.g. disopyramide, verapamil), medicines used to sleeping sickness (e.g. fexinidazole), certain medicines used to treat multiple sclerosis (e.g. fingolimod, siponimod, tizanidine), HIV medications (e.g. atazanavir, saquinavir), certain allergens (e.g. house dust mite allergen extract, mixed grass pollens allergen extract, peanut allergen powder, ragweed pollen allergen extract, timothy grass pollen allergen extract), certain medicines used to diagnose bronchial hyperreactivity (e.g. methacholine), certain bronchodilators (e.g. oxtriphylline), certain medicines used to stop premature labour (e.g. ritodrine) and medicines used to treat asthma (e.g. theophylline, aminophylline, dyphylline).

Drug-Food Interactions: Avoid consumption of alcoholic beverages and potassium-rich foods.

Drug-Disease Interactions: Metpure-XL 25 Tablet may interact with disease conditions, including bradyarrhythmia/AV block, cardiogenic shock/hypotension, CHF (Congestive heart failure), diabetes, haemodialysis, hypersensitivity, ischemic heart disease, PVD (Peripheral vascular disease) and liver disease.

• CLONIDINE
• DILTIAZEM
• CERITINIB
• DOLASETRON
• DISOPYRAMIDE
• VERAPAMIL
• FEXINIDAZOLE
• FINGOLIMOD
• SIPONIMOD
• TIZANIDINE
• ATAZANAVIR
• SAQUINAVIR
• HOUSE DUST MITE ALLERGEN EXTRACT
• MIXED GRASS POLLENS ALLERGEN EXTRACT
• PEANUT ALLERGEN POWDER
• RAGWEED POLLEN ALLERGEN EXTRACT
• TIMOTHY GRASS POLLEN ALLERGEN EXTRACT
• METHACHOLINE
• OXTRIPHYLLINE
• RITODRINE
• THEOPHYLLINE
• AMINOPHYLLINE
• DYPHYLLINE

• Keep your weight under control with a BMI of 19.5-24.9.

• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week.

• Doing this can help lower your raised blood pressure by about 5 mm Hg.

• Option for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.

• Limit sodium chloride (table salt) intake in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.

• If you are taking alcohol, only one serving for women and two servings for men is advisable.

• Quitting smoking is the best strategy to lower the risk of heart disease. 

• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.

• Monitor your blood pressure daily and if there is too much fluctuation, immediately contact your doctor.

• Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil can help lower your elevated blood pressure.

• Metpure-XL 25 Tablet can hide symptoms of low blood sugar if you are diabetic. Monitor your blood sugar levels regularly.

• Do not stop taking Metpure-XL 25 Tablet suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.

Hypertension: High blood pressure is a chronic condition when the blood pressure and the heart's workload are too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Raised blood pressure can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg, and diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm and 120/80 mm Hg.

Angina Pectoris: Discomfort in the chest or the heart is referred to as angina. It occurs when the workload on the heart increases, and the heart does not get as much blood as it needs. Symptoms of angina include chest tightness, pressure and heaviness in the chest.

Arrhythmia: Arrhythmia is a condition with the rate at which the heart beats. In this condition, the heart beats too quickly, too slowly, or at an irregular rate. It can cause significant heart damage. A cardiac arrhythmia develops when there are irregular electrical signals in the heart. Tachycardia occurs when the heart beats too quickly, while bradycardia occurs when it beats too slowly. Arrhythmia treatment involves medicines, medical treatments, implanted devices, and, in certain cases, surgery.

Heart failure: Heart failure is a chronic disorder in which the heart's ability to pump blood is impaired. Heart failure can arise as a result of disorders such as excessive blood pressure, heart muscle enlargement or injury, defective heart valves, or restricted arteries in the heart. Shortness of breath, weariness, a rapid heartbeat, and swelling legs are all symptoms of heart failure.

Stroke: A stroke is a potentially fatal medical illness that occurs when the blood flow to a portion of the brain is cut off. Strokes are a medical emergency that requires immediate treatment. The brain, like all organs, needs the oxygen and nutrients delivered by the blood to function correctly. Brain cells begin to die when the blood supply is reduced or terminated. This can result in brain injury, incapacity, and even death.

Migraine: A migraine headache is typically characterised by intense pain on one side of the brain. Many patients also have symptoms such as nausea, vomiting, and heightened sensitivity to light or sound. Some people suffer from migraines on a regular basis, up to several times per week. Others only get migraines on occasion. It is possible to go years without having a migraine attack. Migraines can have a negative impact on your quality of life and prevent you from carrying out your typical daily activities.