Metnurite 500mg/750mcg Tablet SR used in the treatment of Type 2 diabetes mellitus. Type 2 diabetes mellitus is a chronic or life-long condition in which blood sugar or glucose levels rise more than normal. It occurs when the body does not produce enough insulin (metabolizes glucose), or if produced, it cannot function properly in the body.

Metnurite 500mg/750mcg Tablet SR is a combination of two medicines: Metformin and Methylcobalamin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. It may deplete vitamin B12 levels. So, it is taken with methylcobalamin, which can treat vitamin B12 deficiency. Thus, Metnurite 500mg/750mcg Tablet SR does not cause a sudden lowering of the blood glucose level or significant hypoglycemia.

You should take this medicine as prescribed by your doctor. You may experience side effects such as changes in taste, nausea (feeling sick), vomiting (falling sick), diarrhoea, headache, anorexia (loss of appetite), and sweating. Inform your doctor if any of these side effects persist or worsen.

Do not take Metnurite 500mg/750mcg Tablet SR if you are allergic to any of its contents. Before taking Metnurite 500mg/750mcg Tablet SR, inform your doctor if you have liver problems, severe kidney failure, uncontrolled diabetes, dehydration due to severe diarrhoea or vomiting, severe infections, acute heart failure or heart attack, and alcoholism. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Metnurite 500mg/750mcg Tablet SR is a combination of two medicines: Metformin and Methylcobalamin. Metformin acts by decreasing liver glucose production and intestinal glucose uptake. Methylcobalamin reduces vitamin B12 deficiency. Metnurite 500mg/750mcg Tablet SR does not cause significant hypoglycemia (sudden lowering of the blood glucose level). It is usually preferred in obese patients with diabetes as it may cause weight loss and lower the complications of diabetes.

• Change in taste
• Nausea (feeling sick)
• Vomiting (being sick)
• Diarrhoea
• Hot sensation
• Headache
• Anorexia (loss of appetite)
• Sweating

Metnurite 500mg/750mcg Tablet SR may cause a rare and serious side-effect ‘lactic acidosis’ (buildup of lactic acid in the blood), characterized by abdominal pain, muscle cramps, vomiting, severe fatigue, and difficulty breathing. It is a life-threatening condition that requires immediate medical attention. Inform your doctor if you have any severe liver or kidney problems as their normal functioning is required to eliminate excess lactic acid from the body.  Do not consume excess alcohol as it increases the risk of lactic acidosis. It should be used with caution in patients with heart diseases as it increases the risk of heart failure. If you have dehydration (severe loss of body fluids) due to severe vomiting, diarrhoea, exposure to heat, or fever, stop taking Metnurite 500mg/750mcg Tablet SR and immediately seek medical attention. Metnurite 500mg/750mcg Tablet SR may cause electrolyte imbalance, so taking this medicine during dehydration can worsen the condition.  

Drug-Drug Interaction: Metnurite 500mg/750mcg Tablet SR may interact with other antidiabetic drugs, diuretics or water pills, nonsteroidal anti-inflammatory drugs (ibuprofen and celecoxib), antacids (cimetidine and omeprazole), antiasthma drug (salbutamol), corticosteroids, anti-HIV drug (dolutegravir), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate and lamotrigine), antibiotic (neomycin), a medication used to treat high blood pressure (verapamil), antibacterial (rifampicin and trimethoprim), a medication to treat chest pain (ranolazine), anticancer (vandetanib), and an antifungal drug (isavuconazole).

Drug-Food Interaction: Avoid intake of alcoholic beverages with Metnurite 500mg/750mcg Tablet SR as it increases the risk of lactic acidoses.

Drug-Disease Interaction: Metnurite 500mg/750mcg Tablet SR should be avoided in patients with heart diseases (like congestive heart failure and myocardial infarction), and alcoholic abuse.

• IBUPROFEN
• CELECOXIB
• CIMETIDINE
• OMEPRAZOLE
• SALBUTAMOL
• DOLUTEGRAVIR
• TOPIRAMATE
• LAMOTRIGINE
• NEOMYCIN
• VERAPAMIL
• RIFAMPICIN
• TRIMETHOPRIM
• RANOLAZINE
• VANDETANIB
• ISAVUCONAZOLE

• Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.

• Eat at regular intervals. Do not take the long gap between a meal or snack.

• Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.

• Invest at least 150 min of moderate-intensity physical activity and 15 minutes of high-intensity exercise every week.

• Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).

• Replace refined carbohydrates containing whole-grain foods and increase intake of fruits and veggies and other fibre-enriched foods.

• Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. You may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil for frying.

• Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga, or meditation to control stress-related blood sugar changes.

• Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).

• Keep your blood pressure as normal (120/80) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Beware of hypoglycemia (low blood sugar level) symptoms include sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc. Whenever you experience these symptoms, try to eat 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and get in touch with your doctor. Make sure you carry these with you at all times, especially for long travels. 

Type 2 Diabetes Mellitus: It is a chronic or lifelong disease that keeps the body away from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain, while in rare cases, weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and an increase in the chance of heart attack or stroke.