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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

METALYSE 40MG INJECTION is a clot-busting drug indicated to reduce the risk of death in people who have had a severe type of heart attack known as acute ST-elevation myocardial infarction (STEMI). It contains Tenecteplase, which helps to dissolve unwanted blood clots in the heart's blood vessels. Thus, it helps to prevent damage caused by heart attacks and has been shown to save lives.

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Composition :

TENECTEPLASE-40MG

Manufacturer/Marketer :

Boehringer Ingelheim India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About METALYSE 40MG INJECTION

METALYSE 40MG INJECTION belongs to the class of drugs called thrombolytics (clot-busting drugs) indicated to reduce the risk of death in people who have had a serious type of heart attack known as acute ST-elevation myocardial infarction (STEMI). Heart attack refers to blocked blood flow to the heart due to blockage of arteries. STEMI is a type of serious heart attack that mainly affects the lower chambers of the heart.

METALYSE 40MG INJECTION contains Tenecteplase, a clot-busting drug that helps to dissolve unwanted blood clots in the blood vessels of the heart. Thus, it helps to prevent damage caused by heart attack.

METALYSE 40MG INJECTION will be administered by a healthcare professional; do not self-administer. METALYSE 40MG INJECTION may cause common side effects such as bleeding, nosebleeds, bruising, bleeding at the injection or puncture site, or blood in the urine. If you notice such side effects, please inform your doctor.

If you are allergic to Tenecteplase or any other medicines, please tell your doctor. METALYSE 40MG INJECTION should be used with caution in patients aged over 75 years and who weigh less than 60 kg. METALYSE 40MG INJECTION is not recommended for children below 18 years of age as the safety and effectiveness were not established. If you are a pregnant or breastfeeding woman, please inform your doctor before receiving METALYSE 40MG INJECTION. If you have had a recent major surgery or trauma, inform your doctor. 

Uses of METALYSE 40MG INJECTION

Treatment of Acute myocardial infarction (Heart attack)

Directions for Use

It will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

METALYSE 40MG INJECTION contains Tenecteplase, a clot-busting drug indicated to reduce the risk of death in people who have had a serious type of heart attack known as acute ST-elevation myocardial infarction (STEMI). It helps to dissolve unwanted blood clots in the blood vessels of the heart. Thus, it helps to prevent damage caused by heart attack and has been shown to save lives.

How METALYSE 40MG INJECTION Works

METALYSE 40MG INJECTION contains Tenecteplase, a clot-busting drug that helps to dissolve unwanted blood clots in the blood vessels of the heart. Thus, it helps to prevent damage caused by heart attack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of METALYSE 40MG INJECTION

  • Bleeding
  • Nosebleeds
  • Bruising
  • Bleeding at the injection or puncture site
  • Blood in urine

What if I have taken an overdose of METALYSE 40MG INJECTION

Since METALYSE 40MG INJECTION is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to Tenecteplase or any other medicines, please tell your doctor. METALYSE 40MG INJECTION should be used with caution in patients aged over 75 years of age and who weigh less than 60 kg. METALYSE 40MG INJECTION is not recommended for children below 18 years of age as the safety and effectiveness were not established. If you are a pregnant or breastfeeding woman, please inform your doctor before receiving METALYSE 40MG INJECTION. If you have had a recent major surgery or trauma, inform your doctor. METALYSE 40MG INJECTION is not recommended if you have been given cardiopulmonary resuscitation (chest compressions) for more than 2 minutes duration in the last two weeks. You are advised to be careful while using sharp objects, cutting nails, or shaving, as METALYSE 40MG INJECTION may increase the risk of bleeding. 

Drug-Drug Interactions

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TenecteplaseHeparin
Critical
TenecteplasePrasugrel
Severe

Drug-Drug Interactions

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TenecteplaseHeparin
Critical
How does the drug interact with METALYSE 40MG INJECTION:
Taking METALYSE 40MG INJECTION with Heparin can increase the risk of bleeding.

How to manage the interaction:
Taking Heparin with METALYSE 40MG INJECTION is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TenecteplasePrasugrel
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Taking Prasugrel with METALYSE 40MG INJECTION can increase the risk of bleeding.

How to manage the interaction:
Taking METALYSE 40MG INJECTION with Prasugrel together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TenecteplaseIbrutinib
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Co-administration of Ibrutinib with METALYSE 40MG INJECTION can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibrutinib with METALYSE 40MG INJECTION together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
TenecteplaseDalteparin
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Combining METALYSE 40MG INJECTION with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Although taking Dalteparin with METALYSE 40MG INJECTION may possibly lead to an interaction, they can be taken if a doctor prescribes it. Consult a doctor if you have any symptoms including dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness. Without consulting a doctor, never stop taking any medication.
TenecteplaseEnoxaparin
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Combining METALYSE 40MG INJECTION with Enoxaparin can increase the risk of bleeding.

How to manage the interaction:
Co-administration of METALYSE 40MG INJECTION with Enoxaparin can result in an interaction, but it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. Using more than one of these medications can increase the risk of bleeding even more, but it may not give you much extra protection. Do not discontinue any medications without consulting a doctor.
TenecteplaseDasatinib
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Taking Dasatinib with METALYSE 40MG INJECTION can increase the risk and severity of bleeding and hemorrhage.

How to manage the interaction:
Although taking METALYSE 40MG INJECTION and Dasatinib together can cause an interaction, it can be taken if a doctor has suggested it. You should seek immediate medical attention if you experience dizziness; red or black, tarry stools; severe headache; and weakness. Do not discontinue any medications without consulting a doctor.
TenecteplaseApixaban
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Coadministration of METALYSE 40MG INJECTION and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining METALYSE 40MG INJECTION and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
TenecteplaseDabigatran etexilate
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Taking Dabigatran etexilate with METALYSE 40MG INJECTION can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with METALYSE 40MG INJECTION together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
TenecteplaseDeferasirox
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Combining METALYSE 40MG INJECTION with Deferasirox can increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Co-administration of METALYSE 40MG INJECTION with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
TenecteplaseFondaparinux
Severe
How does the drug interact with METALYSE 40MG INJECTION:
Taking METALYSE 40MG INJECTION with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Taking METALYSE 40MG INJECTION with Fondaparinux together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a diet consisting of vegetables, whole grains, fruits and lean protein.
  • Reduce sugar and processed foods.
  • Include foods high in antioxidants, such as vegetables, fruits, olive oil, seeds, nuts, cocoa, and red wine, as they may lower the risk of developing blood clots.
  • Adopt an anti-inflammatory diet high in omega-3-rich foods, fruits and vegetables, and vitamin-E-rich foods.
  • Drink plenty of fluids as dehydration can thicken blood leading to an increased risk of blood clot formation.
  • Do regular exercise as it helps to dissolve blood clots, especially in obese people.
  • Quit smoking and also avoid being around secondhand smoke.

Habit Forming

No

Therapeutic Class

THROMBOLYTIC ENZYME

METALYSE 40MG INJECTION Substitute

Substitutes safety advice
  • ELAXIM 40MG INJECTION

    46277.50per tablet
  • Tenecterel Kit 40mg Injection

    by AYUR

    40229.20per tablet
  • Tenepact 40 Injection Kit 1's

    41049.20per tablet
  • Telyse 40Mg Inj

    by AYUR

    40499.80per tablet
  • Tenectelex 40 Injection Kit 1's

    46275.10per tablet
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Alcohol

Not applicable

METALYSE 40MG INJECTION is administered to hospitalized patients.

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Pregnancy

Consult your doctor

Limited data is available on the effect of METALYSE 40MG INJECTION in pregnant women. If you are pregnant or planning pregnancy, inform your doctor before receiving METALYSE 40MG INJECTION. Your doctor may give this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

It is unknown whether Tenecteplase is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving METALYSE 40MG INJECTION. Your doctor may give this medicine if the benefits outweigh the risks.

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Driving

Not applicable

METALYSE 40MG INJECTION is administered to hospitalized patients.

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Liver

Consult your doctor

The effect of liver impairment on the actions of METALYSE 40MG INJECTION in humans has not been particularly studied. However, if you have severe liver failure, inform your doctor before receiving METALYSE 40MG INJECTION.

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Kidney

Consult your doctor

The effect of kidney impairment on the actions of METALYSE 40MG INJECTION in humans has not been particularly studied. However, if you have severe kidney problems, inform your doctor before receiving METALYSE 40MG INJECTION.

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Children

Unsafe

METALYSE 40MG INJECTION is not recommended for children below 18 years of age as the safety and effectiveness were not established.

FAQs

METALYSE 40MG INJECTION is used to treat Acute myocardial infarction (Heart attack).
METALYSE 40MG INJECTION contains Tenecteplase, a clot-busting drug that dissolves unwanted blood clots in the blood vessels of the heart. Thus, it helps to prevent damage caused by heart attack.
You are recommended to consult a doctor before taking warfarin while on treatment with METALYSE 40MG INJECTION as it may increase the risk of bleeding more easily. Your doctor may advise dose adjustment. Therefore, please consult a doctor before taking other medicines with METALYSE 40MG INJECTION.
METALYSE 40MG INJECTION may increase the risk of bleeding. Therefore, you are advised to be careful while using sharp objects, cutting nails, or shaving.
METALYSE 40MG INJECTION should be administered through the intravenous (IV) route only. It should be administered by the doctor or nurse. Do not self-administer.
Avoid receiving METALYSE 40MG INJECTION with blood thinners such as heparin, ticlopidine, clopidogrel, and vitamin K antagonists as it may increase the risk of bleeding. However, it is best to avoid self-medicating or taking new drugs without consulting the doctor to ensure safety.
After receiving METALYSE 40MG INJECTION, you may feel better as it starts working to dissolve blood clots and improve blood flow. However, the exact timing varies depending on your medical condition and response to treatment. For some individuals, improvements may be noticeable within hours, while others might take longer. Therefore, always follow up with your doctor to monitor your condition and evaluate your progress.
The side effects of METALYSE 40MG INJECTION include bruising, such as bleeding, nosebleeds, bleeding at the injection or puncture site, or blood in the urine. If you experience any of these symptoms, consult the doctor immediately.

Country of origin

Germany

Manufacturer/Marketer address

1102, Hallmark Business Plaza, 11th Floor, Gurunanak Hospital Road, Near Gurunanak Hospital, Bandra (East), Mumbai 400051
Other Info - MET0498

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