Metabose ER Tablet belongs to the class of anti-diabetic drugs. It is used in the treatment of type 2 diabetes mellitus. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all.

Metabose ER Tablet is composed of two medicines, namely Voglibose and Metformin. Voglibose belongs to the class of alpha-glucosidase inhibitors. It acts by inhibiting the intestinal enzymes, which break complex sugars into simple sugars such as glucose. This process prevents the rise of blood glucose levels. Metformin belongs to the class of biguanides and exhibits non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. Metformin is considered to be a unique anti-diabetic drug since it does not cause hypoglycemia (lowered blood sugar levels).

Take Metabose ER Tablet with food at regular intervals as prescribed by your doctor. Your doctor will decide the dosage form, and this may change timely depending on your blood sugar levels. The common side effects of Metabose ER Tablet include nausea, vomiting, changes in taste, diarrhoea, dizziness, stomach pain, shortness of breath, skin rash, bloating, and flatulence (intestinal wind/gas). Although not everyone experiences these side effects, if they occur, seek medical attention. Lactic acidosis, is a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation is reported. The risk of lactic acidosis is high in people with kidney, liver, and heart diseases.

Before starting Metabose ER Tablet , let your doctor know if you have any medical history of anaemia (low hemoglobin levels), seizures (fits), heart, kidney, and liver diseases. Metabose ER Tablet does not cause hypoglycemia (low blood sugar levels). However, when used with other diabetic drugs like insulin or sulfonylureas, it can lead to hypoglycemia. Also, speak to your doctor if you are on restricted food or fluid intake since Metabose ER Tablet causes dehydration, low blood sugar, and kidney damage. Do not take Metabose ER Tablet if you have gastrointestinal diseases like ulcerative colitis or Crohn’s disease. Do not take or stop Metabose ER Tablet , if the doctor did not advise you to do so.

Metabose ER Tablet is used to treat type 2 diabetes mellitus. It is a combination of Voglibose and Metformin. Voglibose belongs to the class of alpha-glucosidase inhibitors. It delays glucose absorption by inhibiting the intestinal enzymes, which break complex sugars into simple sugars such as glucose. This process prevents the rise of blood glucose levels immediately after meals. Metformin belongs to the class of biguanides. It shows the non-pancreatic effect to reduce serum glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. It is considered to be a unique anti-diabetic drug since it does not lower blood sugar levels. Metformin does not cause weight gain in most cases.

• Nausea

• Vomiting

• Changes in taste

• Diarrhoea

• Dizziness

• Stomach pain

• Shortness of breath

• Skin rash

• Bloating

• Flatulence (intestinal wind/gas)

Metabose ER Tablet may increase the risk of cardiovascular diseases and hypoglycemic conditions in renal and liver disease patients. It can cause pneumatosis intestinalis (gas-filled cysts on the bowel wall) when used along with other alpha-gastrointestinal drugs. It is advised to monitor the gastrointestinal side effects thoroughly to rule out the possibility of pneumatosis intestinalis. Metabose ER Tablet has an increased risk of lactic acidosis (a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation). The risk of lactic acidosis is high in older people with kidney, liver, and heart diseases. Hence, brief your medical history and take advice from your doctor before starting Metabose ER Tablet . Avoid consuming excessive alcohol as it can potentiate lactic acidosis.

Drug-Drug Interaction: Metabose ER Tablet may interact with anti-depressants (selegiline, isocarboxazid, phenelzine), anti-inflammatory drugs (prednisolone, phenylbutazone), drugs that treat fluid retention (metolazone, hydrochlorothiazide, chlorothiazide), medicines used to treat high blood pressure (propranolol, metoprolol), anabolic, and corticosteroids. Please check the instruction leaflet that comes with the medication before you take Metabose ER Tablet .

Drug-Food Interaction: Limit alcohol intake since it affects blood sugar levels. Avoid fatty foods and include healthy carbohydrates in your diet.

Drug-Disease Interaction: Tell your doctor before taking Metabose ER Tablet if you have a medical history of allergic reactions to medicines, heart diseases, liver, and kidney problems. Metabose ER Tablet may cause pneumatosis intestinalis (gas-filled cysts on the bowel wall) when used along with other alpha-gastrointestinal drugs.

• SELEGILINE
• PREDNISOLONE
• PHENYLBUTAZONE
• METOLAZONE
• HYDROCHLOROTHIAZIDE
• METOPROLOL
• PROPRANOLOL
• ISOCARBOXAZID
• PHENELZINE
• CHLOROTHIAZIDE

• Maintain a fiber-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.

• Eat at regular intervals

• Keep a check on your weight and exercise regularly to keep your heart healthy.

• Your doctor also guides you on how to notice and manage the early symptoms of high/low blood sugar levels.

• Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, and avoiding carbonated drinks and foods that cause gas.

Regular blood tests are recommended while taking Metabose ER Tablet to monitor blood sugar levels.

Diabetes Mellitus type 2 is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, excessive insulin is produced but it fails to act on the organs of the body. Symptoms of type 2 diabetes include feeling exhausted all time, feeling thirsty, having blurry vision, and the urge to urinate (pee) more often. Complications of type 2 diabetes include skin infection, eye problems (retinopathy), nerve damage (neuropathy), delayed wound healing, diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke. Both low and high blood sugar levels can be dangerous and should be treated as soon as possible. Your H1bA1C below 5.7% is normal, 5.7-6.4% confirms the prediabetes stage, and 6.5% or greater states diabetes condition.