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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Mesacol Suppository is treating ulcerative colitis and ulcerative proctitis. It contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups. Common side effects of Mesacol Suppository are diarrhoea, stomach pain, headache or nausea.
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Whats That

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Synonym :

MESALAZINE

Composition :

MESALAMINE-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

RECTAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Mesacol Suppository

Mesacol Suppository is used to treat ulcerative colitis and ulcerative proctitis. Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus. Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rear channel (rectum).

Mesacol Suppository contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups.

Use Mesacol Suppository as directed by your physician. Sometimes, you may experience diarrhoea, stomach pain, headache or nausea. Most of these side effects of Mesacol Suppository do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before taking the Mesacol Suppository, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Also, inform your doctor if you have severe kidney or liver failure or blood abnormalities like porphyria. Mesacol Suppository should not be used in pregnant and breastfeeding mothers unless necessary. So, inform your doctor if you are pregnant or breastfeeding. Your doctor will weigh the benefits and potential risks before prescribing Mesacol Suppository.

Uses of Mesacol Suppository

Treatment of Ulcerative colitis and Ulcerative proctitis

Directions for Use

Suppository: Empty your bowels if required. Wash your hands thoroughly before and after use. Lie down on your left side and raise your right knee to the chest. Remove the wrapper and insert the pointed end of the suppository into the rectum. If necessary, grease the suppository tip with petroleum jelly.Enema: Use it as the doctor advises. Shake the bottle well and remove the protective shield from the tip. Lie down on your left side, raise your right knee to the chest, or kneel and lean forward so that the head and chest are resting comfortably. Insert the enema bottle into the rectum with the tip pointing towards the navel. Squeeze the bottle gently until it is empty. Remove the bottle from the rectum and wash your hands thoroughly.Rectal foam: It should be used as directed by your doctor. It is exclusively intended for rectal usage. Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum. Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture. Wash your hands (after usage) and wait till the next morning to empty your bowels. Your doctor will choose the appropriate amount and duration for you based on your age, body weight, and medical state.

Medicinal Benefits

Mesacol Suppository contains Mesalamine, an anti-inflammatory drug used to treat ulcerative colitis and ulcerative proctitis. It can also help treat other inflammatory bowel disease types, such as Crohn’s disease. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. This helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding. Also, Mesacol Suppository may prevent further episodes of ulcerative colitis. It is especially useful when ulcerative colitis symptoms affect the rectum.

How Mesacol Suppository Works

Mesacol Suppository contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mesacol Suppository

  • Feeling sick (Nausea)

  • Being sick (Vomiting)

  • Diarrhoea

  • Stomach pain, indigestion

  • Headaches

  • Muscle aches

What if I have taken an overdose of Mesacol Suppository

Please do not exceed the recommended dose, as it might cause an overdose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. This medicine may be harmful if swallowed. Seek emergency medical attention or call your doctor if you notice any unusual symptoms or if anyone has accidentally swallowed the medication.

Drug Warnings

Before taking the Mesacol Suppository, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Do not use Mesacol Suppository if you are pregnant, planning to become pregnant, or breastfeeding without first consulting the doctor. Mesacol Suppository is recommended not to be used in populations with severe renal or hepatic impairment, so inform your doctor if you have severe renal or hepatic impairment. Use Mesacol Suppository in dose and duration as advised by a doctor only. Do not swallow Mesacol Suppository. In case of accidental swallowing, drink plenty of water and consult a doctor immediately.

Drug-Drug Interactions

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MesalazineCidofovir
Critical
MesalazineTenofovir alafenamide
Severe

Drug-Drug Interactions

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MesalazineCidofovir
Critical
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Mesacol Suppository 5's with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Mesacol Suppository 5's with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineTenofovir alafenamide
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Tenofovir alafenamide with Mesacol Suppository 5's may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Mesacol Suppository 5's with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
MesalazineOmeprazole
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of omeprazole with Mesacol Suppository 5's can decrease the effects of Mesacol Suppository 5's.

How to manage the interaction:
There could be a possible interaction between Mesacol Suppository 5's and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Iodamide with Mesacol Suppository 5's may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Metrizamide with Mesacol Suppository 5's may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol Suppository 5's with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Nizatidine with Mesacol Suppository 5's can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Mesacol Suppository 5's with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineRanitidine
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Ranitidine with Mesacol Suppository 5's can decrease the levels of Mesacol Suppository 5's, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Mesacol Suppository 5's with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineDeferasirox
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Deferasirox with Mesacol Suppository 5's may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Mesacol Suppository 5's and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Mesacol Suppository 5's:
Co-administration of Iomeprol with Mesacol Suppository 5's may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol Suppository 5's and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.

  • Opt for food and drinks high in Omega 3 fatty acids to relieve pain, swelling, and inflammation. Omega 3 rich acid-enriched foods include flaxseeds, walnut, soybean oil, salmon, and tuna if you prefer non-veg.

  • Eat more fibre-rich foods such as fruits and vegetables.

  • Eat smaller meals all day.

  • Drink small amounts of water throughout the day.

  • If you are intolerant to lactose, lower your intake of milk.

  • Avoid foods high in sugar, fat, and processed foods, as these, may cause inflammation.

  • Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS
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Alcohol

Caution

The interaction of alcohol with Mesacol Suppository is unknown. However, avoid consuming alcohol while on treatment with this medicine.

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Pregnancy

Consult your doctor

Mesacol Suppository should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Mesacol Suppository.

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Breast Feeding

Consult your doctor

Mesacol Suppository should not be used while breastfeeding unless necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Mesacol Suppository.

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Driving

Safe

Mesacol Suppository usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving Mesacol Suppository if you have a history of liver diseases/conditions. It should be used cautiously in patients with mild to moderately impaired liver function. It is recommended not to be used in populations with severe liver impairment.

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Kidney

Caution

Inform your doctor before receiving Mesacol Suppository if you have a history of kidney diseases/conditions. It should be used cautiously in patients with mild to moderately impaired kidney function. It is recommended not to be used in populations with severe kidney impairment.

bannner image

Children

Caution

Mesacol Suppository is intended for adults. Not recommended for children.

FAQs

Mesacol Suppository is used to treat ulcerative colitis and ulcerative proctitis.
Mesacol Suppository contains Mesalamine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves stomach pain or bleeding symptoms.
Mesacol Suppository may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using Mesacol Suppository to prevent dehydration.
If you miss a dosage of mesalamine, take it as soon as you remember unless your next dose is approaching. In this situation, skip the missed dose and resume your regular schedule. Do not combine two doses to make up for a missed dosage.
You are recommended not to take Mesacol Suppository with other medications without doctor's notice, especially immunosuppressant medications such as Azathioprine.
No, you are not recommended to stop using Mesacol Suppository suddenly as it may cause recurring symptoms. Therefore, use Mesacol Suppository for as long as your doctor has prescribed it, and if you experience any difficulty while using Mesacol Suppository, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - MES0001

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