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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:36 PM IST
Mesacol Suppository is treating ulcerative colitis and ulcerative proctitis. It contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups. Common side effects of Mesacol Suppository are diarrhoea, stomach pain, headache or nausea.
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Synonym

MESALAZINE

Composition

MESALAMINE-500MG

Consume Type

RECTAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Mesacol Suppository

Mesacol Suppository is used to treat ulcerative colitis and ulcerative proctitis. Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus. Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rear channel (rectum).

Mesacol Suppository contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups.

Use Mesacol Suppository as directed by your physician. Sometimes, you may experience diarrhoea, stomach pain, headache or nausea. Most of these side effects of Mesacol Suppository do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before taking the Mesacol Suppository, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Also, inform your doctor if you have severe kidney or liver failure or blood abnormalities like porphyria. Mesacol Suppository should not be used in pregnant and breastfeeding mothers unless necessary. So, inform your doctor if you are pregnant or breastfeeding. Your doctor will weigh the benefits and potential risks before prescribing Mesacol Suppository.

Uses of Mesacol Suppository

Treatment of Ulcerative colitis and Ulcerative proctitis

Medicinal Benefits

Mesacol Suppository contains Mesalamine, an anti-inflammatory drug used to treat ulcerative colitis and ulcerative proctitis. It can also help treat other inflammatory bowel disease types, such as Crohn’s disease. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. This helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding. Also, Mesacol Suppository may prevent further episodes of ulcerative colitis. It is especially useful when ulcerative colitis symptoms affect the rectum.

Directions for Use

Suppository: Empty your bowels if required. Wash your hands thoroughly before and after use. Lie down on your left side and raise your right knee to the chest. Remove the wrapper and insert the pointed end of the suppository into the rectum. If necessary, grease the suppository tip with petroleum jelly.Enema: Use it as the doctor advises. Shake the bottle well and remove the protective shield from the tip. Lie down on your left side, raise your right knee to the chest, or kneel and lean forward so that the head and chest are resting comfortably. Insert the enema bottle into the rectum with the tip pointing towards the navel. Squeeze the bottle gently until it is empty. Remove the bottle from the rectum and wash your hands thoroughly.Rectal foam: It should be used as directed by your doctor. It is exclusively intended for rectal usage. Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum. Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture. Wash your hands (after usage) and wait till the next morning to empty your bowels. Your doctor will choose the appropriate amount and duration for you based on your age, body weight, and medical state.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mesacol Suppository

  • Feeling sick (Nausea)

  • Being sick (Vomiting)

  • Diarrhoea

  • Stomach pain, indigestion

  • Headaches

  • Muscle aches

Drug Warnings

Before taking the Mesacol Suppository, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. Do not use Mesacol Suppository if you are pregnant, planning to become pregnant, or breastfeeding without first consulting the doctor. Mesacol Suppository is recommended not to be used in populations with severe renal or hepatic impairment, so inform your doctor if you have severe renal or hepatic impairment. Use Mesacol Suppository in dose and duration as advised by a doctor only. Do not swallow Mesacol Suppository. In case of accidental swallowing, drink plenty of water and consult a doctor immediately.

Drug Interactions

Drug-Drug Interactions: Mesacol Suppository may interact with non-steroidal anti-inflammatory drugs (e.g. aspirin, ibuprofen), immunosuppressant medications (e.g. azathioprine), anticoagulants (e.g. warfarin) and laxatives (e.g. lactulose).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Mesacol Suppository may interact with disease conditions, including Severe impairment of hepatic or renal function and a rare blood condition called porphyria.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • IBUPROFEN
  • AZATHIOPRINE
  • WARFARIN
  • LACTULOSE

Habit Forming

No

Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.

  • Opt for food and drinks high in Omega 3 fatty acids to relieve pain, swelling, and inflammation. Omega 3 rich acid-enriched foods include flaxseeds, walnut, soybean oil, salmon, and tuna if you prefer non-veg.

  • Eat more fibre-rich foods such as fruits and vegetables.

  • Eat smaller meals all day.

  • Drink small amounts of water throughout the day.

  • If you are intolerant to lactose, lower your intake of milk.

  • Avoid foods high in sugar, fat, and processed foods, as these, may cause inflammation.

  • Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

Disease/Condition Glossary

Ulcerative colitis: Ulcerative colitis is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, and fever or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite or nausea. The factors involved in causing ulcerative colitis include immune disorders and environmental factors like viruses, bacteria or antigens, which may trigger the immune system and genes inherited from the parent. 

Ulcerative proctitis: Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rear channel (rectum). Proctitis is a painful and unpleasant condition. You may have a persistent urge to urinate. Medications and lifestyle changes are typically used to address the illness.

Crohn's disease: Crohn's disease is a chronic inflammatory disorder that affects the digestive tract. It is a kind of inflammatory bowel disease (IBD). Diarrhoea, stomach aches and cramps, blood in your poo, exhaustion (fatigue), and weight loss are the most common symptoms.

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Alcohol

Caution

The interaction of alcohol with Mesacol Suppository is unknown. However, avoid consuming alcohol while on treatment with this medicine.

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Pregnancy

Consult your doctor

Mesacol Suppository should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Mesacol Suppository.

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Breast Feeding

Consult your doctor

Mesacol Suppository should not be used while breastfeeding unless necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Mesacol Suppository.

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Driving

Safe

Mesacol Suppository usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving Mesacol Suppository if you have a history of liver diseases/conditions. It should be used cautiously in patients with mild to moderately impaired liver function. It is recommended not to be used in populations with severe liver impairment.

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Kidney

Caution

Inform your doctor before receiving Mesacol Suppository if you have a history of kidney diseases/conditions. It should be used cautiously in patients with mild to moderately impaired kidney function. It is recommended not to be used in populations with severe kidney impairment.

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Children

Caution

Mesacol Suppository is intended for adults. Not recommended for children.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - MES0001

Author Details

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FAQs

Mesacol Suppository is used to treat ulcerative colitis and ulcerative proctitis.
Mesacol Suppository contains Mesalamine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves stomach pain or bleeding symptoms.
Mesacol Suppository may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using Mesacol Suppository to prevent dehydration.
If you miss a dosage of mesalamine, take it as soon as you remember unless your next dose is approaching. In this situation, skip the missed dose and resume your regular schedule. Do not combine two doses to make up for a missed dosage.
You are recommended not to take Mesacol Suppository with other medications without doctor's notice, especially immunosuppressant medications such as Azathioprine.
No, you are not recommended to stop using Mesacol Suppository suddenly as it may cause recurring symptoms. Therefore, use Mesacol Suppository for as long as your doctor has prescribed it, and if you experience any difficulty while using Mesacol Suppository, please consult your doctor.

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