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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Megaplat 50Mg Inj is used to treat Colon and rectal cancer. It contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer. Sometimes, Megaplat 50Mg Inj may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

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Composition :

OXALIPLATIN-50MG

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Megaplat 50Mg Inj

Megaplat 50Mg Inj belongs to the group of medicines called platinum-containing antineoplastic agents used alone or in combination with other anti-cancer medicines to treat cancer of the large bowel/intestine (advanced colon or colorectal cancer).

Megaplat 50Mg Inj contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.

In some cases, Megaplat 50Mg Inj may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not use Megaplat 50Mg Inj if you are breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Megaplat 50Mg Inj. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Megaplat 50Mg Inj

Treatment of Colon and rectal cancer

Directions for Use

Megaplat 50Mg Inj will be administered by a qualified physician; do not self-administer.

Medicinal Benefits

Megaplat 50Mg Inj contains Oxaliplatin, which belongs to the group of medicines called platinum-containing antineoplastic agents used to treat stage III colon cancer after complete removal of the primary tumour and metastatic cancer of the colon and rectum. It is used in combination with other anti-cancer medicines, such as 5-fluorouracil and folinic acid. Megaplat 50Mg Inj works by killing the cancer cells. Thereby, it helps treat cancer. Megaplat 50Mg Inj may also be used with other medicines to prevent colon cancer from spreading in patients who have had surgery to remove the tumour.

How Megaplat 50Mg Inj Works

Megaplat 50Mg Inj contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Megaplat 50Mg Inj

  • Mild nausea
  • Vomiting
  • Diarrhoea
  • Headache
  • Peripheral neuropathy
  • Fatigue
  • Back pain
  • Stomach pain

What if I have taken an overdose of Megaplat 50Mg Inj

As Megaplat 50Mg Inj is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Megaplat 50Mg Inj may cause chest pain, diarrhea, numbness or tingling in the fingers or toes, slowed breathing, slowed heartbeat, shortness of breath, tightening of the throat, vomiting, and wheezing.

Drug Warnings

Do not use Megaplat 50Mg Inj if you are allergic to any of its components, if you are breastfeeding, have a low blood cell count, have severe kidney problems, tingling and numbness in the fingers/toes, and have difficulty performing fragile tasks, such as buttoning clothes. Inform the doctor if you ever suffered an allergic reaction to platinum-containing medicines, have mild/moderate kidney problems, liver problems or abnormal liver function tests during therapy, or heart disorders like prolongation of the QT interval (abnormal electrical signal), an irregular heartbeat, or a family history of heart problems. Seek immediate medical attention if you experience symptoms of an allergic reaction (rash, itching, hives, reddening of the skin, hoarseness, difficulty breathing or swallowing, feeling as if your throat is closing, dizziness, swelling of the lips and tongue, lightheadedness, or fainting), unpleasant sensation in the throat, rhabdomyolysis (muscle pain and swelling), nerve problems (sensitivity to cold temperature or cold objects, pain, tingling or burning sensation), Posterior Reversible Encephalopathy Syndrome (headache, confusion, seizures, vision problems), myelosuppression (chills or shivering, burning or pain on urination, pain on swallowing, sore throat, cough with mucus, persistent diarrhoea), lung problems (shortness of breath, wheezing, cough), or bleeding problems (vomit that looks like coffee grounds or bloody vomit, pink or brown urine, weakness, dizziness, changes in speech, confusion, unexplained bleeding or dark-coloured/tarry stools).

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
OxaliplatinHydroxychloroquine
Severe

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
How does the drug interact with Megaplat 50Mg Inj:
Combining Megaplat 50Mg Inj with Ziprasidone can increase the risk of QTc prolongation.

How to manage the interaction:
Taking Megaplat 50Mg Inj with Ziprasidone is not recommended, please consult your doctor before taking it.
OxaliplatinHydroxychloroquine
Severe
How does the drug interact with Megaplat 50Mg Inj:
The combined use of Megaplat 50Mg Inj and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of oxalipatin and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
OxaliplatinMifepristone
Severe
How does the drug interact with Megaplat 50Mg Inj:
Co-administration of Megaplat 50Mg Inj with mifepristone can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Megaplat 50Mg Inj with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
OxaliplatinInfliximab
Severe
How does the drug interact with Megaplat 50Mg Inj:
Combining Infliximab with Megaplat 50Mg Inj can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Megaplat 50Mg Inj with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinCeritinib
Severe
How does the drug interact with Megaplat 50Mg Inj:
Taking Megaplat 50Mg Inj with ceritinib can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Megaplat 50Mg Inj and Ceritinib, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OxaliplatinEfavirenz
Severe
How does the drug interact with Megaplat 50Mg Inj:
Taking Megaplat 50Mg Inj with Efavirenz can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Megaplat 50Mg Inj with Efavirenz together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinThalidomide
Severe
How does the drug interact with Megaplat 50Mg Inj:
Taking thalidomide together with Megaplat 50Mg Inj may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Megaplat 50Mg Inj together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
OxaliplatinNilotinib
Severe
How does the drug interact with Megaplat 50Mg Inj:
Combining Megaplat 50Mg Inj and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Megaplat 50Mg Inj and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
OxaliplatinBaricitinib
Severe
How does the drug interact with Megaplat 50Mg Inj:
Coadministration of baricitinib and Megaplat 50Mg Inj can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Megaplat 50Mg Inj if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
OxaliplatinChloroquine
Severe
How does the drug interact with Megaplat 50Mg Inj:
Using chloroquine together with Megaplat 50Mg Inj can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Megaplat 50Mg Inj together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Megaplat 50Mg Inj Substitute

Substitutes safety advice
  • Oplatin 50Mg/25Ml Inj

    by AYUR

    90.04per tablet
  • Oxalimax 50Mg Inj

    by AYUR

    2205.00per tablet
  • Oxarex 50 mg Injection 1's

    2339.50per tablet
  • Oxalip Injection 1's

    2403.00per tablet
  • Oxitoz 50 mg Injection 1's

    2111.00per tablet
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Alcohol

Consult your doctor

It is not known if alcohol affects Megaplat 50Mg Inj. Please consult your doctor.

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Pregnancy

Unsafe

Megaplat 50Mg Inj may cause foetal harm. Therefore, avoid becoming pregnant during treatment with Megaplat 50Mg Inj.

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Breast Feeding

Unsafe

Breastfeeding is not recommended during treatment with Megaplat 50Mg Inj and for three months after the last dose.

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Driving

Caution

Megaplat 50Mg Inj may cause dizziness or vision problems. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Consult your doctor

If you have a history of liver disease, inform your doctor before receiving Megaplat 50Mg Inj.

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Kidney

Caution

Megaplat 50Mg Inj should not be used if you have severe kidney disease. If you have mild or moderate kidney disease, inform your doctor before receiving Megaplat 50Mg Inj.

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Children

Unsafe

Megaplat 50Mg Inj is not recommended for children as safety and effectiveness have not been established.

FAQs

Megaplat 50Mg Inj is used to treat Colon and rectal cancer.
Megaplat 50Mg Inj works by killing the cancer cells. Thereby, it helps treat cancer.
Megaplat 50Mg Inj may have an anti-fertility effect, which could be irreversible. Therefore, male patients should seek medical advice on the conservation of sperm prior to treatment with Megaplat 50Mg Inj.
Avoid drinking or eating anything colder than room temperature. Do not touch any cold objects, wash your hands in cold water, go near air conditioners or freezers, or go outside in cold weather unless absolutely necessary for five days after you receive each dose of Megaplat 50Mg Inj. Wear a hat, gloves, and a scarf, and cover your mouth and nose if you must go outside in cold weather.
Megaplat 50Mg Inj may decrease the ability to fight infections due to reduced white blood cells. Stay away from sick people during treatment with Megaplat 50Mg Inj.
Megaplat 50Mg Inj is administered to you through an intravenous (IV) infusion. A healthcare professional usually gives it in a clinical setting.
The common side effects of Megaplat 50Mg Inj are mild nausea, vomiting, diarrhoea, headache, peripheral neuropathy, fatigue, back pain, and stomach pain. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Country of origin

India

Manufacturer/Marketer address

PIROJSHANAGAR, ESTERN EXPRESS HIGHWAY VIKHROLI EAST MUMBAI Mumbai City MH 400079 IN
Other Info - MEG0030

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