MEFI 25 TABLETS belongs to the class of medication called 'progestin antagonist' used in combination with Misoprostol to induce a medical abortion. MEFI 25 TABLETS is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help.

MEFI 25 TABLETS contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for MEFI 25 TABLETS to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete.

Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.

MEFI 25 TABLETS should be taken in dose and duration as advised by the doctor, preferably with food. It would be best to take it at a fixed time every day. It is a tablet and should be taken orally with a glass of water. In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of MEFI 25 TABLETS subside with time. But if your vaginal bleeding does not, please visit the doctor immediately, and it requires immediate medical attention.

MEFI 25 TABLETS should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting MEFI 25 TABLETS if you have or ever had an ectopic pregnancy (when the fetus grows in the fallopian tube), using an intrauterine device, or if you are breastfeeding, any bleeding disorder or heart problem. Do not do strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

MEFI 25 TABLETS contains Mifepristone, which is taken in a regimen with Misoprostol to induce medical abortion or terminate a pregnancy before 70 days. It works by blocking the effect of progesterone (female hormone) needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for MEFI 25 TABLETS to show effect.

• Weakness
• Nausea
• Uterine cramps
• Vomiting
• Diarrhoea
• Dizziness
• Infection following abortion
• Uterine bleeding

Women who have an ectopic pregnancy (a pregnancy outside of the uterus, problems with the adrenal glands (the glands near the kidneys), currently taking corticosteroid therapy (medications), have an allergic reaction to mifepristone, misoprostol or similar drugs, have bleeding problems or taking the blood-thinning drug (warfarin, clopidogrel, aspirin, heparin etc.) should not use MEFI 25 TABLETS and contact doctor. After using MEFI 25 TABLETS if you start feeling sleepy, do not drive or operate heavy machinery. If you use an intrauterine device (IUD), please remove it before taking the MEFI 25 TABLETS . Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (herbal supplements to treat mild depression) and grapefruit juice should not be taken when taking MEFI 25 TABLETS as it is known to interact. 

Drug-Drug Interactions: MEFI 25 TABLETS interacts with corticosteroids (dexamethasone), antifungal (ketoconazole, itraconazole), antibiotics (erythromycin, rifampicin),  anti-epileptic (phenytoin, phenobarbital, carbamazepine), immunosuppressants (cyclosporine, tacrolimus, sirolimus), medicines to treat migraine (ergotamine). So, MEFI 25 TABLETS should not be taken along with these drugs.

Drug-Food Interactions: Please tell your doctor about all the Vitamins, herbs, and supplements you are taking as the MEFI 25 TABLETS may interact with them to produce unpleasant side effects. Also, MEFI 25 TABLETS is known to interact with St John’s Wort (a natural remedy used to treat mild depression) and grapefruit juice.

Drug-Disease Interactions: MEFI 25 TABLETS should be taken with caution in people with a bleeding problem, confirmed or suspected ectopic pregnancy, heart problem, liver or kidney disease, or vaginal bleeding.

• DEXAMETHASONE
• KETOCONAZOLE
• ITRACONAZOLE
• ERYTHROMYCIN
• RIFAMPICIN
• PHENYTOIN
• PHENOBARBITAL
• CARBAMAZEPINE
• CYCLOSPORINE
• TACROLIMUS
• SIROLIMUS
• ERGOTAMINE

• Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
• Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
• Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.
• Avoid chronic stress and physical exercise like running, as it might increase vaginal bleeding.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• Get an ultrasound to check if the abortion is done completely to avoid unwanted complications.
• Try to include heart-healthy omega-3 fatty acid-containing foods or drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• MEFI 25 TABLETS should not be used to end the pregnancy after ten weeks.
• Contact your doctor immediately if you experience heavy vaginal bleeding after taking this medicine.

Medical abortion: It is a procedure in which medicine is used to end a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.