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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Mef 500mg Tablet is used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, and arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, it is used to relieve period pain and premenstrual syndrome symptoms (PMS) and manage excessively heavy periods. It contains Mefenamic acid, which works by blocking the effect of chemical messengers that cause pain and inflammation. In some cases, you may experience certain common side effects such as abdominal pain, nausea, vomiting, diarrhoea, heartburn and indigestion. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Consume Type :

ORAL

Return Policy :

Not Returnable

About Mef 500mg Tablet

Mef 500mg Tablet is used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, and arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, Mef 500mg Tablet is used to relieve period pain and premenstrual syndrome symptoms (PMS) and manage excessively heavy periods.

Mef 500mg Tablet contains 'mefenamic acid', which works by blocking the effect of chemical messengers that cause pain and inflammation.  Thereby relieving pain and inflammation.

In some cases, you may experience certain common side effects such as abdominal pain, nausea, vomiting, diarrhoea, heartburn and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Mef 500mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Mef 500mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Mef 500mg Tablet

Treatment of Pain and inflammation.

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or break the tablet/capsule.Dispersible tablet: Disperse the tablet in water and consume it.

Medicinal Benefits

Mef 500mg Tablet belongs to a group of medicines called NSAID (Non-Steroidal Anti-Inflammatory Drug) used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, Mef 500mg Tablet is used to relieve period pain, symptoms of premenstrual syndrome (PMS), and management of excessively heavy periods. Mef 500mg Tablet works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. 

How Mef 500mg Tablet Works

Mef 500mg Tablet contains 'mefenamic acid', which works by blocking the effect of chemical messengers that cause pain and inflammation.  Thereby relieving pain and inflammation.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mef 500mg Tablet

  • Abdominal pain 
  • Nausea 
  • Vomiting 
  • Diarrhoea 
  • Indigestion
  • Heartburn

What if I have taken an overdose of Mef 500mg Tablet

Do not take more than the prescribed dose of Mef 500mg Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, extreme tiredness, stomach pain, vomit that is bloody or looks like coffee grounds, black/tarry/bloody stools, slowed breathing or coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Mef 500mg Tablet if you are allergic to any of its components, if you have severe heart, kidney or liver failure, suffered bleeding problems such as bleeding from the stomach or bowels while taking any pain killers or have peptic ulcers or inflammatory bowel disease. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, dehydration, asthma, liver and kidney problems. Consult your doctor if you are pregnant or breastfeeding. Mef 500mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Stop taking Mef 500mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach such as blood in stools.

Drug-Drug Interactions

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Mefenamic acidMeloxicam
Critical
Mefenamic acidKetorolac
Critical

Drug-Drug Interactions

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Mefenamic acidMeloxicam
Critical
How does the drug interact with Mef 500mg Tablet:
Co-administration of Mef 500mg Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mef 500mg Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acidKetorolac
Critical
How does the drug interact with Mef 500mg Tablet:
Coadministration of Mef 500mg Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Mef 500mg Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidNaproxen
Severe
How does the drug interact with Mef 500mg Tablet:
Coadministration of Mef 500mg Tablet with Naproxen can increase the risk or severity of stomach bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mef 500mg Tablet with Naproxen together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidBaricitinib
Severe
How does the drug interact with Mef 500mg Tablet:
Using Mef 500mg Tablet and baricitinib together may increase the risk of gastrointestinal perforation (a serious health condition where a hole develops through the stomach or intestine).

How to manage the interaction:
Co-administration of Mef 500mg Tablet with Baricitinib can result in an interaction, but it can be taken if your doctor has advised it. If you notice any signs like severe stomach pain, fever, or vomiting, consult a doctor. Do not stop using any medications without talking to a doctor.
Mefenamic acidFondaparinux
Severe
How does the drug interact with Mef 500mg Tablet:
Taking Mef 500mg Tablet with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Fondaparinux with Mef 500mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding or bruising, feeling dizzy or lightheaded, dark or bloody stools, headache, weakness contact your doctor right away. Do not stop using any medications without first talking to your doctor.
Mefenamic acidDasatinib
Severe
How does the drug interact with Mef 500mg Tablet:
Co-administration of Mef 500mg Tablet with Dasatinib can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mef 500mg Tablet with Dasatinib together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black tarry stools, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidPiroxicam
Severe
How does the drug interact with Mef 500mg Tablet:
Coadministration of Mef 500mg Tablet with Piroxicam can increase the risk side effects such as inflammation(swelling with redness and pain), bleeding, ulceration, and perforation leading to serious blood loss.

How to manage the interaction:
Taking Mef 500mg Tablet with Piroxicam together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidEnoxaparin
Severe
How does the drug interact with Mef 500mg Tablet:
Combining Mef 500mg Tablet with Enoxaparin can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Although there is a possible interaction between Mef 500mg Tablet and Enoxaparin, you can take these medicines together if prescribed by your doctor. If you notice any symptoms like bleeding, bruising, swelling, vomiting, headache, dizziness, weakness, or blood in your urine or stool, make sure to contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidIndometacin
Severe
How does the drug interact with Mef 500mg Tablet:
The combined use of Indometacin and Mef 500mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.

How to manage the interaction:
Taking Indometacin with Mef 500mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
Mefenamic acidDeferasirox
Severe
How does the drug interact with Mef 500mg Tablet:
Coadministration of Mef 500mg Tablet with Deferasirox can increase the risk or severity of gastric bleeding.

How to manage the interaction:
Taking Mef 500mg Tablet with Deferasirox together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of increased or decreased urination, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MEFENAMIC ACID-500MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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MEFENAMIC ACID-500MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Mef 500mg Tablet with caffeine-containing foods or drinks can show an interaction. Taking Mef 500mg Tablet with caffeine-containing foods or drinks can reduce the effectiveness of Mef 500mg Tablet. Avoid or limit your caffeine consumption while taking Mef 500mg Tablet dose. Do not stop using any medications without talking to a doctor.

Diet & Lifestyle Advise

  • Mild exercises such as jogging and walking are helpful for muscle stretching.

  • Massages can also be helpful.

  • Avoid freezing and hot temperatures.

  • Avoid wearing tight-fitting clothes, instead, wear loose garments.

  • Rest well, get plenty of sleep.

  • To avoid developing pressure sores, change your position at least every two hours.

  • Hot or cold therapy can help treat pain. Apply an ice-pack or hot-pack on the muscle for 15-20minutes.

  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

Mef 500mg Tablet Substitute

Substitutes safety advice
  • Meftal-500 Tablet 10's

    2.79per tablet
  • Mictal-500mg Tablet 10's

    by AYUR

    2.29per tablet
  • Av-Cid Mf Tablet 10'S

    by AYUR

    20.25per tablet
  • Mefmin 500 Tablet 10's

    2.70per tablet
  • Meflup 500mg Tablet

    0.74per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Mef 500mg Tablet as it may increase drowsiness. It can also increase the risk of stomach bleeding.

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Pregnancy

Caution

Mef 500mg Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Mef 500mg Tablet may pass into breastmilk. Consult your doctor if you are breastfeeding.

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Driving

Caution

Mef 500mg Tablet may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Please consult your doctor. Your doctor will recommend it based on your child's condition.

FAQs

Mef 500mg Tablet is used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, and arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, it is used to relieve period pain and premenstrual syndrome symptoms (PMS) and manage excessively heavy periods.
Mef 500mg Tablet works by blocking the chemical messengers that are responsible for pain and inflammation. Thereby, Mef 500mg Tablet provides relief from pain and inflammation.
Mef 500mg Tablet is generally prescribed for short-term use. Do not take Mef 500mg Tablet for longer durations as it might increase the risk of heart problems and stomach bleeding.
Mef 500mg Tablet is used to relieve menstrual (period) pain, symptoms of premenstrual syndrome (PMS), and management of excessively heavy periods. Take only as prescribed by the doctor.
Avoid taking Mef 500mg Tablet if you have stomach ulcers. Mef 500mg Tablet might increase the risk of stomach ulcers, perforation of the stomach and intestinal bleeding with higher doses.
Diarrhoea might be a side-effect of Mef 500mg Tablet. Drink plenty of fluids and eat food rich in fibre. Consult your doctor if you experience excessive diarrhoea or if you find blood in stools.
It is considered harmful for patients with severe kidney problems and those experiencing active intravascular clotting, which obstructs blood flow due to blood clots.
Store Mef 500mg Tablet at room temperature, away from sunlight. Keep the Mef 500mg Tablet out of reach of children.
No, Mef 500mg Tablet doesn’t act as a contraceptive, it is used to manage excessive bleeding.
Mef 500mg Tablet should be taken only as it is prescribed by the doctor. Do not self-medicate and do not recommend Mef 500mg Tablet to others with same condition.
Mef 500mg Tablet is not recommended during pregnancy unless advised by the doctor. Therefore, if you are pregnant or planning for the pregnancy, please consult a doctor.
If the dose of Mef 500mg Tablet is missed then, take the missed dose as soon as you remember and if it is the time for the next dose, skip the missed dose and continue taking regular dose. Avoid taking the double dose to make up for the missed one.
Mef 500mg Tablet is used for short time, not more than 3-5 days of your menstrual cycle. However the duration for your use will be advised by the doctor. Do not self-medicate.

Country of origin

India
Other Info - ME79350

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