Mahagesic-MR 8 Capsule is a combination medication primarily used to reduce and relieve pain due to muscle spasms (painful muscular contractions) associated with degenerative vertebral disorders, torticollis (neck muscle contractions), and upper and lower back pain. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable.

Mahagesic-MR 8 Capsule is a combination of two drugs: Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (pain killer/NSAID) and relieves pain. It inhibits cyclo-oxygenase (COX) enzymes and further prevents the formation of chemical messengers, 'prostaglandins' (PGs), that cause pain and swelling at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This helps reduce muscle stiffness and improves muscle movements, thereby relieving pain due to muscle spasms.

Your doctor will decide the dose and duration based on the severity of your pain. Common side effects of Mahagesic-MR 8 Capsule include nausea, vomiting, loss of appetite, stomach pain, diarrhoea, and heartburn. These side effects are not familiar to everyone and vary individually. However, if the side effects are persistent, please reach out to your doctor.

Before starting Mahagesic-MR 8 Capsule , inform your doctor if you have any liver, heart or kidney diseases, high blood pressure, diabetes, stomach ulcers, asthma, muscular hypotonia (decreased muscle tone), flaccid paresis (loose and floppy limbs), autoimmune diseases (systemic lupus erythematosus), and smoking habit. Mahagesic-MR 8 Capsule is not recommended for pregnant and breastfeeding women. Mahagesic-MR 8 Capsule should not be given to children and adolescents below 18 years of age as safety has not been established. Avoid consuming alcohol while undergoing treatment with Mahagesic-MR 8 Capsule . 

Mahagesic-MR 8 Capsule treats pain due to muscle spasms. It contains Diclofenac and Thiocolchicoside. Diclofenac is a non-steroidal anti-inflammatory drug (NSAIDs) and relieves pain. It inhibits cyclo-oxygenase (COX) enzymes that further prevents the formation of chemical messengers called 'prostaglandins (PGs). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside is a muscle relaxant that works on the centres of the spinal cord and brain. This helps reduce muscle stiffness and improves muscle movements, thereby relieving pain due to muscle spasms.

• Nausea
• Vomiting
• Stomach pain
• Diarrhoea
• Loss of appetite
• Heartburn

Inform your doctor if you have any liver, heart or kidney diseases, high blood pressure, diabetes, stomach ulcers, asthma, muscular hypotonia (decreased muscle tone), flaccid paresis (loose and floppy limbs), autoimmune diseases (systemic lupus erythematosus), and smoking habit. Please consult your doctor before starting Mahagesic-MR 8 Capsule if you have high cholesterol, chickenpox, porphyria (rare inherited disorder), hereditary disorders like Lapp lactase deficiency (lactose intolerance), galactose intolerance, glucose-galactose malabsorption (small intestines not being able to absorb and use glucose and galactose), fits, and blood clotting disorders. Do not take any other NSAIDs for pain relief along with Mahagesic-MR 8 Capsule unless prescribed. Stop taking Mahagesic-MR 8 Capsule and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Mahagesic-MR 8 Capsule is not recommended for pregnant and breastfeeding women. Mahagesic-MR 8 Capsule may cause dizziness and drowsiness, so drive only if you are alert and focused. Avoid consuming alcohol while being treated with Mahagesic-MR 8 Capsule . This medicine is not recommended in children and adolescents below 18 years of age as safety and efficacy are not established.

Drug-Drug Interaction: Mahagesic-MR 8 Capsule may interact with anti-diabetics, blood thinners (warfarin), water pills, anti-depressants (lithium), anti-cancer drugs (methotrexate), immunosuppressants (ciclosporin, tacrolimus), drugs treating urinary tract infections (Trimethoprim), medicines used for abortion (mifepristone), pain killers (aspirin, ibuprofen), heart-related drugs (digoxin), antibiotics (voriconazole), fits medicines (phenytoin), and cholesterol-lowering drugs (cholestyramine, colestipol).

Drug-Food Interaction: Avoid alcohol consumption while using this medicine to avoid the risk of adverse effects.

Drug-Disease Interaction: Before starting Mahagesic-MR 8 Capsule , inform your doctor if you have stomach ulcers, blood disorders, galactose intolerance, Lapp lactase deficiency, fits, muscular hypotonia, asthma, porphyria, diabetes, high blood pressure, autoimmune diseases, connective tissue diseases, heart, kidney, and liver problems.

• WARFARIN
• LITHIUM
• METHOTREXATE
• CICLOSPORIN
• TACROLIMUS
• TRIMETHOPRIM
• MIFEPRESTONE
• ASPIRIN
• IBUPROFEN
• DIGOXIN
• VORICONAZOLE
• PHENYTOIN
• COLESTIPOL
• CHOLESTYRAMINE

• Exercising regularly helps in muscle stretching, reducing spasm, tear and sprain incidence. Mild exercises, such as jogging and walking are helpful for muscle stretching.
• Massages can also be helpful to ease the pain.
• Avoid wearing tight-fitting clothes; wear loose garments for proper blood circulation.
• Rest well and get plenty of sleep.
• Hot or cold therapy can help treat muscle spasms. Apply an ice or hot pack on the muscle for 15-20 minutes.
• Stay hydrated; drink plenty of water.

• Let your doctor know that you are taking Mahagesic-MR 8 Capsule if you are undergoing any medical tests.
• Your doctor may recommend liver function tests to monitor your liver functioning.

Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. When the nerve impulses that control the muscle movements are damaged or interrupted, it could lead to muscle spasms. Symptoms include muscle tightness, joint stiffness, unusual posture, difficulty moving, pain in affected muscles and joints. Fatigue (weakness), stress, extreme heat or cold, infection and tight clothing can trigger muscle spasms. Muscle relaxants and exercise can treat muscle spasms. Muscle relaxants sedate the muscle and help in inhibiting painful contractions. At the same time, exercise helps in muscle stretching to be less likely to spasm, tear and sprain.