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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Madopar 250 Tablet is used to treat Parkinson’s disease. It contains Levodopa and Benserazide which work by increasing the dopamine levels in the brain that is important for movement control. In some cases, this medicine may cause side effects such as nausea, vomiting, loss of appetite, weight gain, constipation, and tiredness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Madopar 250 Tablet

Madopar 250 Tablet is used to treat Parkinson’s disease. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion. It causes stiffness, shaking, difficulty in walking, coordination, and balance. These symptoms interfere with daily activities and decrease the quality of life.

Madopar 250 Tablet contains Levodopa and Benserazide. Levodopa is a dopamine agonist and acts by increasing the dopamine levels in the brain. Dopamine is a chemical messenger present in the brain that is important for movement control. Benserazide is a decarboxylase inhibitor. It prevents the breakdown of levodopa and increases its effectiveness. Together, Madopar 250 Tablet can effectively reduce the symptoms of Parkinson’s disease.

You should take this medicine exactly as prescribed by the doctor. The common side-effects of Madopar 250 Tablet are Involuntary jerking movements of the body, agitation, hallucinations (seeing or hearing things that are not true), nausea, vomiting, loss of appetite, weight gain, constipation, skin rash, itching, confusion, tiredness, water retention, and difficulty sleeping or sudden onset of sleep episodes. These side effects are usually seen in the initial days of therapy. However, if any of these side effects persist or get worse, inform your doctor immediately.

It is not recommended to take Madopar 250 Tablet if you are allergic to any contents of it. Do not take Madopar 250 Tablet if you have glaucoma (increased pressure in the eye), serious liver, kidney, or heart problems, overactive thyroid, severe mental illness, skin cancer, and have been using non-selective monoamine oxidase inhibitor (MAOI) in the last 14 days. It is not recommended for use in individuals less than 25 years of age, pregnant women, and breastfeeding mothers. It should be used with caution in the elderly, as dose adjustments may be necessary. Do not consume alcohol, as it may increase the risk of side effects. Madopar 250 Tablet may affect your ability to drive, so do not drive or operate heavy machinery if you are not fully alert.

Uses of Madopar 250 Tablet

Treatment of Parkinson’s disease.

Directions for Use

Swallow Madopar 250 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Madopar 250 Tablet is used in the treatment of Parkinson’s disease. It replaces the deficient dopamine in the brain, which is essential for the brain's normal functioning. It helps to improve muscle control, thereby allowing the body to have more normal movements. It reduces the symptoms of Parkinson’s disease, thereby improving the quality of life.

How Madopar 250 Tablet Works

Madopar 250 Tablet contains Levodopa and Benserazide. Levodopa is a dopamine agonist and acts by increasing the dopamine levels in the brain. Dopamine is a chemical messenger present in the brain that is important for movement control. Benserazide is a decarboxylase inhibitor. It prevents the breakdown of levodopa and increases its effectiveness. Together, Madopar 250 Tablet can effectively reduce the symptoms of Parkinson’s disease.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Madopar 250 Tablet

  • Involuntary jerking movements of the body

  • Agitation

  • Hallucinations (seeing or hearing things that are not true)

  • Nausea

  • Vomiting

  • Loss of appetite

  • Diarrhea

  • Irregular heartbeat (faster or slower than normal)

  • Weight gain

  • Constipation

  • Skin rash

  • Itching

  • Confusion

  • Tiredness

  • Water retention

  • Anaemia (low numbers of red blood cells)

  • Changes to how things taste or a loss of taste

  • Difficulty sleeping or sudden onset of sleep episodes

What if I have taken an overdose of Madopar 250 Tablet

Take Madopar 250 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include cardiac arrhythmia, confusion, insomnia, nausea, and vomiting. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Before taking Madopar 250 Tablet , inform your doctor if you have hormonal problems, diabetes, heart problems, stomach ulcer, and osteomalacia (soft and weak bones). Do not take this medicine if you have been taking non-selective monoamine oxidase inhibitors (MAOI) such as isocarboxazid and phenelzine in the last 14 days. If you notice impulse control disorders such as gambling addiction, increased libido (sexual desire), sexual addiction, compulsive spending or buying, and binge eating, inform your doctor immediately. In such cases, the doctor may reduce the dose or stop the treatment based on your condition.

Drug-Drug Interactions

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LevodopaProcarbazine
Critical
LevodopaTranylcypromine
Critical

Drug-Drug Interactions

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LevodopaProcarbazine
Critical
How does the drug interact with Madopar 250 Tablet 10's:
Using Madopar 250 Tablet 10's together with procarbazine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Procarbazine with Madopar 250 Tablet 10's together can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
LevodopaTranylcypromine
Critical
How does the drug interact with Madopar 250 Tablet 10's:
Taking Tranylcypromine with Madopar 250 Tablet 10's can increase the risk of high blood pressure

How to manage the interaction:
Taking Madopar 250 Tablet 10's with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
LevodopaPhenelzine
Critical
How does the drug interact with Madopar 250 Tablet 10's:
Using Madopar 250 Tablet 10's together with phenelzine can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Madopar 250 Tablet 10's with Phenelzine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness and fainting. Do not discontinue any medications without consulting your doctor.
LevodopaAmisulpride
Severe
How does the drug interact with Madopar 250 Tablet 10's:
Coadministration of Madopar 250 Tablet 10's with amisulpride may increase the risk and severity of side effects and also reduce the effectiveness of both drugs.

How to manage the interaction:
Although taking amisulpride and Madopar 250 Tablet 10's can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor if you experience drowsiness, low blood pressure, dizziness, and lightheadedness. Do not discontinue any medications without consulting a doctor.
LevodopaLinezolid
Severe
How does the drug interact with Madopar 250 Tablet 10's:
Using Madopar 250 Tablet 10's together with linezolid can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between linezolid and Madopar 250 Tablet 10's, you can take these medicines together if prescribed by a doctor. However, if you experience a sudden and severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting, you should seek immediate medical attention. Do not stop using any medications without talking to a doctor.
LevodopaIsocarboxazid
Severe
How does the drug interact with Madopar 250 Tablet 10's:
Using Madopar 250 Tablet 10's together with isocarboxazid can increase blood pressure and increase the risk of side effects.

How to manage the interaction:
Taking Isocarboxazid with Madopar 250 Tablet 10's together can possibly result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor right away if you experience symptoms like severe headache, confusion, chest pain, or sudden weakness. Do not stop using any medications without a doctor's advice.
LevodopaEsketamine
Severe
How does the drug interact with Madopar 250 Tablet 10's:
Coadministration of Madopar 250 Tablet 10's with Esketamine can increase the risk of side effects.

How to manage the interaction:
Although taking Madopar 250 Tablet 10's and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sleepiness, confusion, difficulty concentrating, and impairment in thinking, judgment consult your doctor immediately. Do not stop using any medications without a doctor's advice.
LevodopaGlycopyrronium bromide
Severe
How does the drug interact with Madopar 250 Tablet 10's:
Coadministration of Madopar 250 Tablet 10's with glycopyrronium bromide can significantly decrease the blood levels of Madopar 250 Tablet 10's.

How to manage the interaction:
Although using glycopyrronium bromide and Madopar 250 Tablet 10's together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any unusual symptoms contact the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid high protein foods like soy protein, fish, eggs, chicken, beef, and pork. Eat more whole-grain foods such as whole-wheat bread, oatmeal, brown rice, or pasta.

  • Eat more fiber-rich foods to ease constipation.

  • Drink plenty of water to avoid headaches due to dehydration.

  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS
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Alcohol

Caution

Do not consume alcohol as it may increase the risk of side-effects.

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Pregnancy

Caution

Madopar 250 Tablet may cause harmful effects to the unborn baby when used in pregnant women. So, it is used only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

Madopar 250 Tablet may cause harmful effects to the nursing baby when used in breastfeeding mothers. So, it is used only if the doctor thinks the benefits outweigh the risks.

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Driving

Unsafe

Madopar 250 Tablet may cause sudden onset of sleepiness. So, it is advised not to drive or operate heavy machinery while using Madopar 250 Tablet .

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Liver

Caution

Madopar 250 Tablet should be used with caution if you have a history of liver diseases. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Madopar 250 Tablet should be used with caution if you have a history of kidney diseases. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Madopar 250 Tablet is not recommended for children as the safety and efficacy were not established.

FAQs

Madopar 250 Tablet is used to treat Parkinson’s disease, a disorder of the central nervous system that affects movement and locomotion.
Madopar 250 Tablet contains 'Levodopa' and ‘Benserazide’, which is used to treat Parkinson's disease. Levodopa works by increasing dopamine levels, a chemical messenger present in the brain that causes symptoms of Parkinson's disease. Benserazide prevents the breakdown of Levodopa, thereby improving its efficacy.
Madopar 250 Tablet can cause drowsiness. Some patients taking this medicine may also experience a sudden onset of sleepiness without any warning signs. So, it would be best if you refrained from activities that require you to stay alert, such as driving or operating heavy machinery.
Madopar 250 Tablet may alter test results of some blood or urine tests. So, it is essential to let your doctor know before undergoing any laboratory tests.
Madopar 250 Tablet is not recommended for patients with glaucoma (damage of optic nerve due to increased pressure in the eye) as it may increase the fluid pressure inside the eye.
Inform your doctor if you notice any impulsive behaviors such as the urge to eat, gamble, spend money, or increased sexual desire. Madopar 250 Tablet may cause drowsiness, so do not drive or operate heavy machinery.
The effects of Madopar 250 Tablet on bones with long-term use are not known. There is no clear evidence that Madopar 250 Tablet directly affects bones. Please contact a doctor if you have any concerns or for any personalized advice.
Madopar 250 Tablet causes side effects such as nausea, vomiting, loss of appetite, diarrhoea, irregular heartbeat, weight gain, constipation, skin rashes, confusion, tiredness, and anemia (low number of red blood cells). Please consult a doctor immediately if any of these side effects persist longer.

Country of origin

India

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - MAD0017

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