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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Macox-ZH Tablet is used to treat tuberculosis. It works by inhibiting the growth of the tuberculosis-causing bacteria. This medicine may sometimes cause side effects such as weakness, nausea, vomiting, stomach pain, and joint or muscle pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Macox-ZH Tablet

Macox-ZH Tablet belongs to the group of medicines called 'anti-tuberculosis drugs' primarily used to treat tuberculosis, also known as TB. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis that mainly affects the lungs but can also spread to other body parts such as kidneys, brain, spine, and bone marrow. Macox-ZH Tablet does not work against infections caused by the virus, including colds and flu.

Macox-ZH Tablet combines three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).

Take Macox-ZH Tablet as prescribed. Sometimes, you may experience common side effects such as weakness, nausea, vomiting, stomach pain, and joint or muscle pain. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to your doctor if you experience these side effects persistently.

Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking Macox-ZH Tablet as they might cause interaction. Maintain a gap of one hour between Macox-ZH Tablet and antacid medicines. Consult your doctor before taking Macox-ZH Tablet if you are pregnant. Avoid breastfeeding while taking Macox-ZH Tablet as it passes into breast milk.

Uses of Macox-ZH Tablet

Macox-ZH Tablet is used to treat Tuberculosis.

Directions for Use

Tablet/Capsule: Take it on an empty stomach, i.e., 30 minutes before food or 2 hours after food. Swallow it as a whole; do not crush or chew it.Dispersible tablet: Disperse the tablet in a teaspoonful of boiled and cooled water before administration.

Medicinal Benefits

Macox-ZH Tablet combines three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Macox-ZH Tablet belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat tuberculosis. Rifampicin inhibits DNA-dependent RNA polymerase activity in bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).

How Macox-ZH Tablet Works

Macox-ZH Tablet combines three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Macox-ZH Tablet

  • Weakness
  • Nausea
  • Vomiting
  • Stomach pain
  • Joint or muscle pain

What if I have taken an overdose of Macox-ZH Tablet

Take Macox-ZH Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include stomach pain, nausea, vomiting, headache, lack of energy, and itching. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Macox-ZH Tablet if you are allergic to any of its contents, if you have jaundice, or if you are taking HIV medicines (saquinavir or ritonavir). Before starting Macox-ZH Tablet, please inform your doctor if you have diabetes, epilepsy, gout, mental health problems, HIV infection, malnutrition, peripheral neuropathy, porphyria, bleeding problems, kidney or liver problems. Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer, while taking Macox-ZH Tablet as they might cause interaction. Maintain a gap of one hour between Macox-ZH Tablet and antacid medicines. Consult your doctor before taking Macox-ZH Tablet if you are pregnant. Avoid breastfeeding while taking Macox-ZH Tablet as it passes into breast milk. Macox-ZH Tablet may cause dizziness, and vision problems, so drive cautiously. Avoid alcohol consumption while taking Macox-ZH Tablet as it could lead to increased liver damage. Keep your doctor informed about your health condition and all the medicines you take to rule out any interactions.

Drug-Drug Interactions

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IsoniazidLovastatin
Critical
IsoniazidLomitapide
Critical

Drug-Drug Interactions

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IsoniazidLovastatin
Critical
How does the drug interact with Macox-ZH Tablet 6's:
When Lovastatin is taken with Macox-ZH Tablet 6's, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Macox-ZH Tablet 6's with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
IsoniazidLomitapide
Critical
How does the drug interact with Macox-ZH Tablet 6's:
When Lomitapide is taken with Macox-ZH Tablet 6's, Macox-ZH Tablet 6's may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Macox-ZH Tablet 6's with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidRegorafenib
Critical
How does the drug interact with Macox-ZH Tablet 6's:
When Macox-ZH Tablet 6's is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Macox-ZH Tablet 6's is not recommended, it taken can be taken if prescribed by the doctor.
RifampicinPirfenidone
Critical
How does the drug interact with Macox-ZH Tablet 6's:
Taking pirfenidone with Macox-ZH Tablet 6's can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and Macox-ZH Tablet 6's, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with Macox-ZH Tablet 6's:
Taking Voriconazole with Macox-ZH Tablet 6's can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with Macox-ZH Tablet 6's, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinSaquinavir
Critical
How does the drug interact with Macox-ZH Tablet 6's:
Taking saquinavir with Macox-ZH Tablet 6's can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Macox-ZH Tablet 6's, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with Macox-ZH Tablet 6's:
When ranolazine is taken with Macox-ZH Tablet 6's, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Macox-ZH Tablet 6's, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with Macox-ZH Tablet 6's:
When Indinavir is taken with Macox-ZH Tablet 6's, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Macox-ZH Tablet 6's, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinDarunavir
Critical
How does the drug interact with Macox-ZH Tablet 6's:
Taking darunavir with Macox-ZH Tablet 6's can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Macox-ZH Tablet 6's, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
IsoniazidPhenytoin
Severe
How does the drug interact with Macox-ZH Tablet 6's:
Using Phenytoin together with Macox-ZH Tablet 6's may increase the effects of Phenytoin, which may increase the risk of side effects.

How to manage the interaction:
Although taking Phenytoin and Macox-ZH Tablet 6's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience jerky eye movements, slurred speech, loss of balance, shaking, muscle stiffness or weakness, nausea, vomiting, feeling dizzy, fainting, and slow or shallow breathing, consult a doctor immediately. Do not discontinue the medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help relieve cough.
  • Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

Macox-ZH Tablet Substitute

Substitutes safety advice
  • RCINEX Z TABLET

    9.00per tablet
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Alcohol

Unsafe

Avoid alcohol consumption while taking Macox-ZH Tablet as it could lead to increased liver damage.

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Pregnancy

Caution

Please consult your doctor if you are pregnant, planning for pregnancy or think you are pregnant; your doctor will prescribe Macox-ZH Tablet only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Macox-ZH Tablet passes into breast milk. Do not breastfeed while taking Macox-ZH Tablet.

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Driving

Unsafe

Macox-ZH Tablet may cause dizziness, vision problems, numbness and tingling sensation in hands and feet. Do not drive or operate machinery if you experience these symptoms.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Macox-ZH Tablet if you have liver impairment/liver disease before taking Macox-ZH Tablet.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Macox-ZH Tablet.

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Children

Consult your doctor

Please consult your doctor. Based on your child's age, body weight, and medical condition, your doctor may suggest a suitable dose and dosage form.

FAQs

Macox-ZH Tablet is used to treat tuberculosis (TB).
Macox-ZH Tablet is a combination of three anti-tuberculosis drugs: Rifampicin, Isoniazid, and Pyrazinamide. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Pyrazinamide inhibits the growth of the bacteria. Together, Macox-ZH Tablet kills Mycobacterium tuberculosis, which causes TB (tuberculosis).
Do not stop taking Macox-ZH Tablet despite symptomatic relief. To treat your condition effectually, continue taking Macox-ZH Tablet for as long as it has been prescribed for you.
Do not take Macox-ZH Tablet along with antacids, which might decrease its effectiveness. Maintain a minimum gap of 1 hour between both.
Consult your doctor before taking Macox-ZH Tablet with other medicines. Medicines used to treat TB, such as PAS (P-amino salicylic acid) and cycloserine, should be taken 8 hours apart from Macox-ZH Tablet if prescribed.
Macox-ZH Tablet contains isoniazid, which might interact with foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer. Avoid these foods while taking Macox-ZH Tablet.
Macox-ZH Tablet might decrease the effectiveness of oral contraceptives (birth control pills). This could lead to an unplanned pregnancy. Instead, use a reliable barrier method of contraception such as condoms or the coil while taking Macox-ZH Tablet. Consult your doctor if you have any concerns regarding this; your doctor may suggest an alternate method of contraception.
Macox-ZH Tablet may cause discolouration of teeth, sweat, urine, sputum (phlegm), saliva, or tears. The colour in tears may last for some time, even after you stop taking Macox-ZH Tablet. Do not worry, as it is a common side-effect of Macox-ZH Tablet.
Yes, Macox-ZH Tablet might permanently stain soft contact lenses. Use spectacles and avoid wearing contact lenses while taking Macox-ZH Tablet.
Macox-ZH Tablet may affect the results of some blood tests, such as those for folate, vitamin B12, and liver function. Inform the person performing the tests that you are taking Macox-ZH Tablet.
Macox-ZH Tablet may cause liver problems, especially in people aged 35 and older. Consult your doctor if you notice symptoms such as yellowing of eyes or skin, dark urine, pale stools, weakness, loss of appetite, nausea or vomiting. Your doctor may advise you to get regular liver tests while taking Macox-ZH Tablet to check how your liver is functioning.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0035

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