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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MACOX PLUS 150MG TABLET is used to treat tuberculosis in children. It contains Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, they kill Mycobacterium tuberculosis, which causes TB (tuberculosis). Common side effects of MACOX PLUS 150MG TABLET are nausea, vomiting, diarrhoea, stomach pain, and loss of appetite.

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Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About MACOX PLUS 150MG TABLET

MACOX PLUS 150MG TABLET is used to treat tuberculosis in children. Tuberculosis is an infectious disease that mainly affects the lungs but can also spread to other body parts such as the kidneys, brain, spine, and bone marrow.
 
MACOX PLUS 150MG TABLET contains Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, MACOX PLUS 150MG TABLET kills Mycobacterium tuberculosis which causes TB (tuberculosis).
 
In some cases, MACOX PLUS 150MG TABLET may cause side effects such as nausea, vomiting, diarrhoea, stomach pain, and loss of appetite. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to the doctor if the side effects persist or worsen.
 
Let your doctor know if your child is allergic to any of the components in MACOX PLUS 150MG TABLET. Keep your doctor informed about your child's health condition and medications to rule out any side effects/interactions.

Uses of MACOX PLUS 150MG TABLET

MACOX PLUS 150MG TABLET is used in the treatment of Tuberculosis

Directions for Use

MACOX PLUS 150MG TABLET should be given on an empty stomach, i.e., one hour prior or two hours after meals.Liquid: Administer the prescribed dose using a measuring cup/dosing syringe/dropper. Shake the bottle well before use.

Medicinal Benefits

MACOX PLUS 150MG TABLET belongs to the group of medicines called anti-tuberculosis drugs primarily used to treat and prevent tuberculosis. MACOX PLUS 150MG TABLET contains two anti-mycobacterial agents, Rifampicin and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, MACOX PLUS 150MG TABLET kills Mycobacterium tuberculosis which causes TB (tuberculosis).

How MACOX PLUS 150MG TABLET Works

MACOX PLUS 150MG TABLET contains Rifampicin, and Isoniazid. Rifampicin inhibits DNA-dependent RNA polymerase activity in the bacteria. Isoniazid inhibits the biosynthesis of mycolic acid, which is the major component of the cell wall. Together, MACOX PLUS 150MG TABLET kills Mycobacterium tuberculosis which causes TB (tuberculosis).

Storage

Store in a cool and dry place away from sunlight

Side Effects of MACOX PLUS 150MG TABLET

  • Nausea
  • Vomiting
  • Diarrhoea
  • Stomach pain
  • Loss of appetite

What if I have taken an overdose of MACOX PLUS 150MG TABLET

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of MACOX PLUS 150MG TABLET may include altered sensorium, generalized tonic-clonic seizures, renal and hepatic dysfunctions, and severe metabolic acidosis. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not give MACOX PLUS 150MG TABLET to the child if he/she is allergic to any of the components in MACOX PLUS 150MG TABLET, if he/she has acute liver disease, drug-induced liver disease, if the child has experienced liver damage linked to rifampicin or isoniazid, or if the child is taking anti-fungal (voriconazole) or medicines for HIV infection (protease inhibitors). MACOX PLUS 150MG TABLET may cause liver damage; consult your doctor if the child experiences symptoms such as unexplained loss of appetite, nausea, vomiting, jaundice, dark urine, persistent fatigue for more than 3 days, abdominal pain and tenderness. Consult a doctor if your child gets flu-like symptoms such as headache, fever, or muscle ache. Inform the doctor if your child has HIV infection, epilepsy, psychiatric disorder, diabetes, porphyria, phenylketonuria (metabolic disorder), peripheral neuropathy (tingling sensation in hands and feet), kidney or liver problems, if your child is allergic to ethionamide or niacin (nicotinic acid), or if your child is taking cortisone or any cortisone-like drug. 

Drug-Drug Interactions

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RifampicinPirfenidone
Critical
RifampicinVoriconazole
Critical

Drug-Drug Interactions

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RifampicinPirfenidone
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
Taking pirfenidone with MACOX PLUS 150MG TABLET can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and MACOX PLUS 150MG TABLET, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
Taking Voriconazole with MACOX PLUS 150MG TABLET can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with MACOX PLUS 150MG TABLET, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinSaquinavir
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
Taking saquinavir with MACOX PLUS 150MG TABLET can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and MACOX PLUS 150MG TABLET, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
When ranolazine is taken with MACOX PLUS 150MG TABLET, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and MACOX PLUS 150MG TABLET, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
When Indinavir is taken with MACOX PLUS 150MG TABLET, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and MACOX PLUS 150MG TABLET, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinDarunavir
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
Taking darunavir with MACOX PLUS 150MG TABLET can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and MACOX PLUS 150MG TABLET, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
IsoniazidLovastatin
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
When Lovastatin is taken with MACOX PLUS 150MG TABLET, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking MACOX PLUS 150MG TABLET with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
IsoniazidLomitapide
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
When Lomitapide is taken with MACOX PLUS 150MG TABLET, MACOX PLUS 150MG TABLET may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking MACOX PLUS 150MG TABLET with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidRegorafenib
Critical
How does the drug interact with MACOX PLUS 150MG TABLET:
When MACOX PLUS 150MG TABLET is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with MACOX PLUS 150MG TABLET is not recommended, it taken can be taken if prescribed by the doctor.
RifampicinAtorvastatin
Severe
How does the drug interact with MACOX PLUS 150MG TABLET:
Taking atorvastatin with MACOX PLUS 150MG TABLET can decrease the blood levels of atorvastatin, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between atorvastatin and MACOX PLUS 150MG TABLET, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli, and bell pepper, help improve the immune system. 
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from a cough.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

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Breast Feeding

Not applicable

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Driving

Not applicable

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Liver

Consult your doctor

Please consult the doctor if your child has a liver impairment or if you have any concerns regarding this.

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Kidney

Consult your doctor

Please consult the doctor if your child has kidney problems.

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Children

Safe if prescribed

MACOX PLUS 150MG TABLET is safe for children if prescribed by the doctor. Your doctor may prescribe the dose and duration based on the child's condition and age.

FAQs

MACOX PLUS 150MG TABLET is used to treat Tuberculosis.
MACOX PLUS 150MG TABLET works by killing Mycobacterium tuberculosis which causes TB (tuberculosis).
MACOX PLUS 150MG TABLET may cause reddish-orange discolouration of body fluids such as tears, sputum and urine; this is not harmful and does not require medical attention. However, consult your doctor if you have any concerns.
MACOX PLUS 150MG TABLET might stain soft contact lenses. The child should use spectacles and avoid wearing contact lens while taking MACOX PLUS 150MG TABLET.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0034

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