Macirol Tablet belongs to the class of 'anti-hypertensive drugs', primarily used to treat high blood pressure in the lungs' arteries (pulmonary arterial hypertension). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of blood vessels. This condition makes the heart work harder in pumping blood to the whole body. Pulmonary hypertension affects arteries in the lungs and the right side of the heart.

Macirol Tablet contains 'macitentan', which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. Macirol Tablet widens the constricted pulmonary arteries (blood vessels that carry blood from the heart to the lungs) and increases blood supply, thus lowering blood pressure.

Take Macirol Tablet as prescribed by your doctor. Your dose and duration of Macirol Tablet will be advised by your doctor, depending upon your medical condition. In some cases, you may experience headaches, inflammation of the airways, and oedema. Most of these side effects of Macirol Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Please inform your doctor if you are using any prescription, or non-prescription drugs, including vitamins and herbal products. Before starting Macirol Tablet , let your doctor know if you have allergic reactions to Macirol Tablet or other medicines. Inform your doctor if you have low blood pressure, lung, heart, kidney, liver problems, and anaemia (lack of blood cells). It is advised to consult a doctor if you are a pregnant or breastfeeding mother. Do not stop taking Macirol Tablet without consulting your doctor since it may worsen your condition and increase the risk of future heart problems. Do not consume alcohol with Macirol Tablet as it may increase the risk of low blood pressure.

Macirol Tablet is an anti-hypertensive medicine that treats high blood pressure in the lungs' arteries (pulmonary arterial hypertension (PAH)). It contains 'Macitentan,' which works by inhibiting the action of Endothelin, a natural substance that constricts blood vessels and raises blood pressure. In people with PAH, the pulmonary arteries get narrower making the heart work harder to pump blood through them. Macirol Tablet widens these constricted arteries and makes it easier for the heart to pump blood, thus lowering the blood pressure.

• Anaemia (low number of red blood cells) or reduced haemoglobin
• Headache
• Bronchitis (inflammation of the airways)
• Nasopharyngitis (inflammation of the throat and nasal passages)
• Oedema (swelling), especially of the ankles and feet

Please inform your doctor beforehand if you are allergic to Macirol Tablet or other medicines. Brief your medical history if you have heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention) and hypotension (low blood pressure) before starting Macirol Tablet . Macirol Tablet is contraindicated during pregnancy since it harms the foetus. Please get a pregnancy test done before starting Macirol Tablet . You should get a negative pregnancy test for sure before using Macirol Tablet . Also, please use reliable forms of birth control if you are undergoing treatment with Macirol Tablet to avoid pregnancy. Consult your doctor before using Macirol Tablet if you are a breastfeeding mother. Complete the course strictly as the doctor advises, even if you feel better, to avoid the recurrence of the disease. Do not drive or operate machinery since Macirol Tablet may cause side effects like dizziness and weakness, affecting your ability to concentrate and drive. Avoid consumption of alcohol with Macirol Tablet as it may increase the risk of low blood pressure. Macirol Tablet is not recommended in patients younger than 18 years of age.

Drug-Drug Interactions: Macirol Tablet may interact with antibiotics (e.g. rifampicin, clarithromycin), a medicine used to treat seizures (e.g. phenytoin), a medicine used to treat depression and epilepsy (e.g. carbamazepine), medications used to treat HIV infections (e.g. ritonavir, saquinavir), anti-fungal medicines (e.g. fluconazole, itraconazole), a drug used to control the heartbeat (e.g. amiodarone), a medicine used to prevent organ rejection after transplant (e.g. cyclosporine), medications used to treat high blood pressure or specific heart problems (e.g. diltiazem, verapamil).

Drug-Food Interactions: Alcohol may increase the side effects of Macirol Tablet . Hence, it is advised to limit the intake of alcohol while using Macirol Tablet .

Drug-Disease Interactions: People with heart failure, liver or kidney diseases, lung conditions (pulmonary fibrosis), anaemia, oedema (fluid retention), low blood pressure, and severe dehydration should consult the doctor before taking Macirol Tablet .

• RIFAMPICIN
• CLARITHROMYCIN
• PHENYTOIN
• CARBAMAZEPINE
• RITONAVIR
• SAQUINAVIR
• FLUCONAZOLE
• ITRACONAZOLE
• CYCLOSPORINE
• DILTIAZEM
• VERAPAMIL

• Maintain a diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.
• Keep your weight under control with a BMI of 19.5-24.9.
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
• Try to include heart-healthy omega-3-fatty acids containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil and coconut oil to lower your elevated blood pressure.
• Be mindful of salt; consume no more than 2,300 mg each day.
• Limit or avoid alcohol consumption.
• Quitting smoking is the best strategy to lower the risk of heart disease.

• Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor.
• Your doctor may ask you to undergo a blood test whether you have anaemia (a reduced number of red blood cells).
• If you have diabetes, using Macirol Tablet may affect your blood sugar levels. Inform your doctor so that you may adjust your diabetes medication accordingly.
• Your dietician may prescribe you a suitable exercise program and diet to manage your blood pressure.
• Your doctor may also suggest liver function tests.

Pulmonary Arterial Hypertension: It is referred to as high blood pressure in the blood vessels (the pulmonary arteries) that carry blood from the heart to the lungs. It's a serious condition that can harm the heart's right side. The walls of the pulmonary arteries thicken and stiffen, making it difficult for blood to flow through. Because of the reduced blood flow, the right side of the heart has a harder time pumping blood through the arteries which may lead to heart failure. The common symptoms of pulmonary hypertension are shortness of breath, dizziness, palpitations, and chest pressure. It can affect people of all ages, but it is more common in people who already have a heart or lung problem.