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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Luprovian 3.75 mg Injection Combipack is used to treat prostate cancer in men, endometriosis & hormone-responsive breast cancer in women and premature puberty in children. It contains Leuprorelin which works by decreasing the levels of testosterone in men and oestrogen in women. It also inhibits the growth of the tumour or causes it to shrink. In some cases, this medicine may cause side effects such as pain, redness, swelling, or skin hardening at the injection site. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

LEUPRORELIN-3.75MG

Manufacturer/Marketer :

Nivian Pharma Llp

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Luprovian 3.75 mg Injection Combipack

Luprovian 3.75 mg Injection Combipack belongs to the class of synthetic hormones used in the treatment of prostate cancer in men, endometriosis, and hormone-responsive breast cancer in women. Also, Luprovian 3.75 mg Injection Combipack is used to treat premature puberty in children. Prostate cancer is cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems.

Luprovian 3.75 mg Injection Combipack contains Leuprorelin, a synthetic hormone that works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and estrogen in women. Thereby, Luprovian 3.75 mg Injection Combipack is used in the treatment of prostate cancer by inhibiting the growth of the tumor or causing it to shrink.  

Use Luprovian 3.75 mg Injection Combipack as prescribed by your doctor. You are advised to take Luprovian 3.75 mg Injection Combipack for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience pain, redness, swelling, or skin hardening at the injection site, muscle weakness, bone pain, inability to have an erection, breast tenderness, headache, vaginal dryness, changes in breast size, acne, or mood swings. Most of these side effects of Luprovian 3.75 mg Injection Combipack do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Luprovian 3.75 mg Injection Combipack or any other medicines, please tell your doctor. Luprovian 3.75 mg Injection Combipack is contraindicated in pregnant and breastfeeding women. It is advised to use effective contraceptive measures to avoid pregnancy while taking Luprovian 3.75 mg Injection Combipack as it may cause birth defects. Luprovian 3.75 mg Injection Combipack should be used with caution in children. You are recommended to avoid or limit consumption of alcohol with Luprovian 3.75 mg Injection Combipack as it may increase the risk of bone density loss. Drive only if you are alert as Luprovian 3.75 mg Injection Combipack may cause dizziness, drowsiness, or vision disturbances.

Uses of Luprovian 3.75 mg Injection Combipack

Treatment of Prostate cancer, Breast cancer, Endometriosis, Premature puberty

Directions for Use

Luprovian 3.75 mg Injection Combipack will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Luprovian 3.75 mg Injection Combipack contains Leuprorelin which works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and oestrogen in women. Thereby, Luprovian 3.75 mg Injection Combipack is used in the treatment of prostate cancer by inhibiting the growth of the tumour or causing it to shrink.  Also, Luprovian 3.75 mg Injection Combipack is used to treat hormone-responsive breast cancer in pre and postmenopausal women. By reducing testosterone and oestrogen levels, Luprovian 3.75 mg Injection Combipack delays the onset of puberty in children.

How Luprovian 3.75 mg Injection Combipack Works

Luprovian 3.75 mg Injection Combipack contains Leuprorelin, a synthetic hormone that works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and estrogen in women. Thereby, Luprovian 3.75 mg Injection Combipack is used in the treatment of prostate cancer by inhibiting the growth of the tumor or causing it to shrink.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Luprovian 3.75 mg Injection Combipack

In men:

  • Muscle weakness
  • Bone pain
  • Inability to have an erection
  • Tiredness
  • Decreased interest in sex

In women:

  • Breast tenderness
  • Difficulty in sleeping
  • Headache
  • Vaginal dryness
  • Changes in breast size

In children:

  • Acne
  • Mood swings
  • Vaginal bleeding
  • Pain, redness, swelling or skin hardening at the injection site

What if I have taken an overdose of Luprovian 3.75 mg Injection Combipack

It is unlikely to overdose on parenteral medication as it is administered by a healthcare professional. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

If you are allergic to Luprovian 3.75 mg Injection Combipack or any other medicines, please tell your doctor. Luprovian 3.75 mg Injection Combipack is contraindicated in pregnant and breastfeeding women. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Luprovian 3.75 mg Injection Combipack as it may cause birth defects. Luprovian 3.75 mg Injection Combipack should be used with caution in children. You are advised to quit smoking as it may increase the risk of prostate cancer. You are recommended to avoid or limit consumption of alcohol with Luprovian 3.75 mg Injection Combipack as it may increase the risk of bone density loss. Drive only if you are alert as Luprovian 3.75 mg Injection Combipack may cause dizziness, drowsiness or vision disturbances.

Drug-Drug Interactions

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LeuprorelinIbutilide
Critical
LeuprorelinDofetilide
Critical

Drug-Drug Interactions

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LeuprorelinIbutilide
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
LeuprorelinVandetanib
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking Luprovian 3.75 mg Injection Combipack with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinCisapride
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Luprovian 3.75 mg Injection Combipack with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinCitalopram
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Coadministration of Luprovian 3.75 mg Injection Combipack and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinPimozide
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking Luprovian 3.75 mg Injection Combipack with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinNilotinib
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeuprorelinEliglustat
Critical
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Luprovian 3.75 mg Injection Combipack with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinProcainamide
Severe
How does the drug interact with Luprovian 3.75 mg Injection Combipack:
Taking leuprolide with procainamide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Luprovian 3.75 mg Injection Combipack and procainamide together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli, and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Avoid grilled meat, red meat, and saturated fat found in animal products, milk, and dairy products as they may increase the risk of prostate cancer.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Quit smoking to reduce the risk of prostate cancer.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.

Habit Forming

No

Therapeutic Class

GONADOTROPHIN-RELEASING HORMONE AGONIST

Luprovian 3.75 mg Injection Combipack Substitute

Substitutes safety advice
  • Luprova 3.75 Injection 1's

    by AYUR

    2858.50per tablet
  • Leuprolide Depot 3.75mg Injection 1's

    3234.49per tablet
  • Palutor 3.75 mg Combipack Injection 1's

    3000.00per tablet
  • Endorelin Depot 3.75Mg Inj

    by AYUR

    2505.92per tablet
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Alcohol

Caution

Avoid or limit alcohol consumption with Luprovian 3.75 mg Injection Combipack as it may increase the risk of bone density loss.

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Pregnancy

Unsafe

Luprovian 3.75 mg Injection Combipack is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Luprovian 3.75 mg Injection Combipack is contraindicated in breastfeeding women. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Luprovian 3.75 mg Injection Combipack may cause dizziness, drowsiness or disturbance in the vision. Therefore, avoid driving if you experience any of these symptoms after taking Luprovian 3.75 mg Injection Combipack.

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Liver

Caution

Take Luprovian 3.75 mg Injection Combipack with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Luprovian 3.75 mg Injection Combipack with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Luprovian 3.75 mg Injection Combipack should be used for children under the supervision of a paediatric endocrinologist.

FAQs

Luprovian 3.75 mg Injection Combipack contains Leuprorelin, a synthetic hormone that works similar to the natural hormone, gonadotropin-releasing hormone (GnRH) by acting on the pituitary gland and decreases the levels of testosterone in men and oestrogen in women. Thereby, Luprovian 3.75 mg Injection Combipack is used in the treatment of prostate cancer by inhibiting the growth of tumour or causing it to shrink.
Luprovian 3.75 mg Injection Combipack may stop menstrual periods. However, after 7 to 12 weeks of taking the final dose of injection, periods will resume. Please consult a doctor if you have any concerns regarding this.
Luprovian 3.75 mg Injection Combipack should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, it is advised to regularly monitor blood sugar levels while taking Luprovian 3.75 mg Injection Combipack and inform your doctor if you have diabetes before taking Luprovian 3.75 mg Injection Combipack.
Luprovian 3.75 mg Injection Combipack may be used to treat endometriosis (tissue lining the uterus known as endometrium grows outside the uterus). Luprovian 3.75 mg Injection Combipack reduces oestrogen levels and causes menopause temporarily. Thereby, shrink the tissue outside the uterus or stop its growth.
Luprovian 3.75 mg Injection Combipack may decrease bone density, especially when used for the treatment of premature puberty in children. Therefore, regular monitoring of bone density is recommended while taking Luprovian 3.75 mg Injection Combipack.
Luprovian 3.75 mg Injection Combipack should be used with extreme caution in patients suffering from depression as it may worsen the condition. Therefore, inform your doctor if you have any history of depression before taking Luprovian 3.75 mg Injection Combipack.
No, Luprovian 3.75 mg Injection Combipack is not a chemotherapy medicine. It is a synthetic hormone which belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists.
Yes, Luprovian 3.75 mg Injection Combipack is a hormonal medicine that works by altering reproductive hormones. It is not recommended for use during pregnancy as it can harm the fetus and may lead to abortion. If you are pregnant or planning to become pregnant, please inform your doctor.
The common side effects of Luprovian 3.75 mg Injection Combipack are pain, redness, swelling, or skin hardening at the injection site, muscle weakness, bone pain, inability to have an erection, breast tenderness, headache, vaginal dryness, changes in breast size, acne, or mood swings. If any of these side effects persist or worsen, please consult your doctor.
Luprovian 3.75 mg Injection Combipack belongs to the class of synthetic hormones used in the treatment of prostate cancer in men, endometriosis, and hormone-responsive breast cancer in women. Also, it is used to treat premature puberty in children.

Country of origin

India

Manufacturer/Marketer address

302, Lotus Plaza, Corner Of Gokhle Road And M.G. Road, Village, Naupada, Thane, Maharashtra 400062
Other Info - LUP0359

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