Lupride Depot 45 mg Injection belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis. Additionally, it is also used to treat precocious puberty (early puberty) in children. Lupride Depot 45 mg Injection is used in combination with other medicines to treat anaemia caused by uterine fibroids.

Lupride Depot 45 mg Injection contains Leuprolide acetate, which is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer and helps treat endometriosis.

Lupride Depot 45 mg Injection will be administered by a healthcare professional. The common side effects of Lupride Depot 45 mg Injection include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site reaction. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Avoid taking Lupride Depot 45 mg Injection if you are pregnant or breastfeeding. Both women and men using Lupride Depot 45 mg Injection should use effective contraception. Lupride Depot 45 mg Injection may affect fertility, hence discuss with your doctor if you have any plans to start a family in the future. Lupride Depot 45 mg Injection is not recommended for children below two years of age. Lupride Depot 45 mg Injection may cause dizziness, hence drive only if you are alert.

Lupride Depot 45 mg Injection contains Leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist. It treats prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. Lupride Depot 45 mg Injection is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. Lupride Depot 45 mg Injection works by lowering testosterone levels in men that help stop the growth of cancer cells in prostate cancer. Lupride Depot 45 mg Injection reduces oestrogen (a hormone required for the development and regulation of the female reproductive system and secondary sexual characteristics) levels in women, thus helping in endometriosis.

• Weight changes
• Hot flushes
• Muscle weakness
• Bone Pain
• Loss of interest in sexual intercourse
• Tiredness
• Difficulty sleeping
• Headaches
• Nausea
• Breast tenderness
• Changes in breast size
• Mood swings
• Abdominal pain

If you are allergic to Lupride Depot 45 mg Injection or any other medicines, please tell your doctor. Lupride Depot 45 mg Injection is not indicated for use in pregnancy and breastfeeding women. If you are using Lupride Depot 45 mg Injection, make sure to use reliable forms of contraception. Lupride Depot 45 mg Injection may also affect fertility in men, hence discuss with your doctor if you have any plans to start a family in the future. Lupride Depot 45 mg Injection is not recommended for children younger than two years of age. If you have a seizure or unusual changes in mood or behaviour, inform your doctor immediately. Before starting Lupride Depot 45 mg Injection, let your doctor know if you have liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. Lupride Depot 45 mg Injection may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) and may affect heart rhythm, hence heart patients should be cautious while taking Lupride Depot 45 mg Injection. Lupride Depot 45 mg Injection can make you feel dizzy and affects your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused.

Drug-Drug Interaction: Lupride Depot 45 mg Injection may interact with heart rhythm problems treating drugs (quinidine, procainamide, disopyramide, amiodarone, sotalol), steroids (dexamethasone, methylprednisolone) and antibiotics (moxifloxacin), opioid pain killers (methadone)antipsychotics and antidepressants (citalopram, escitalopram, fluoxetine, paroxetine, sertraline).

Drug-Food Interaction: No interactions found/established.

Drug-Disease Interaction: Lupride Depot 45 mg Injection should be used with caution in cases of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels.

• QUINIDINE
• PROCAINAMIDE
• DISOPYRAMIDE
• AMIODARONE
• SOTALOL
• DEXAMETHASONE
• METHYLPREDNISOLONE
• MOXIFLOXACIN
• METHADONE
• CITALOPRAM
• ESCITALOPRAM
• FLUOXETINE
• SERTRALINE
• PAROXETINE

• Maintain a fibre-rich diet and include fruits, vegetables and whole grains.
• Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
• Avoid grilled meat, red meat, saturated fat found in animal products, milk and dairy products.
• Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
• Eat at regular intervals.
• Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.

• Your doctor may advise liver function tests to monitor your liver health since Lupride Depot 45 mg Injection may cause increased liver enzymes (alanine aminotransferase, serum aspartate and serum transaminases).
• Lupride Depot 45 mg Injection may cause increased serum glucose levels (hyperglycaemia), hence inform your doctor if you have diabetes before starting Lupride Depot 45 mg Injection.
• Your doctor may advise blood tests, electrolyte levels and regular examinations of the prostate.

• It is advised to get an electrocardiogram (ECG) done timely to monitor your heart health.

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder that secretes fluid that nourishes and protects sperm) found in men. The symptoms include difficulty in urination, pain, numbness or sexual problems. It is the most common type of cancer in men.

Endometriosis: It is a disorder in which tissue lining the uterus grows outside the uterine cavity. It commonly involves ovaries, fallopian tubes and the tissue lining the pelvis. Symptoms of endometriosis include pain and irregular periods.

Precocious Puberty: Precocious puberty occurs when a child's body changes into that of an adult or experiences puberty too soon. If puberty begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. Symptoms in a girl include first period and breast development, whereas, in a boy, it causes enlarged testicles and penis, deepening voice and facial hair.