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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 26, 2024 | 7:08 PM IST
Lupisulide Syrup is used to treat pain and dysmenorrhea (painful periods or menstrual cramps). Besides this, it is also used to treat dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction, or injury. It contains Nimesulide, which works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in the body. It may cause common side effects like nausea, diarrhoea, changes in liver enzymes, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Prescription drug

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Composition

NIMESULIDE-50MG

Manufacturer/Marketer

Lupin Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Lupisulide Syrup

Lupisulide Syrup belongs to a class of painkillers called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) used to treat pain and dysmenorrhea (painful periods or menstrual cramps). Besides this, it is also used to treat dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction, or injury. 

Lupisulide Syrup contains Nimesulide, which works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in the body.

Take Lupisulide Syrup as prescribed. Like all medicines, Lupisulide Syrup may cause common side effects like nausea, diarrhoea, changes in liver enzymes, and vomiting. Most of these side effects do not necessitate medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult a doctor.

Do not take Lupisulide Syrup if you are allergic to any of its components. It is not recommended for use in children, people with liver disease, heart disease, and gastric ulcers/bleeding problems. Lupisulide Syrup may affect fertility and can pass in milk. The use of Lupisulide Syrup should be avoided in pregnant and nursing mothers. Inform your doctor if you have heart problems, as it may increase the risk of heart attack (myocardial infarction).

Uses of Lupisulide Syrup

Treatment of Pain relief

Medicinal Benefits

Lupisulide Syrup is composed of nimesulide, primarily used to treat mild to moderate pain. Lupisulide Syrup works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in the body. 

Directions for Use

Tablet/Capsule: Swallow it as a whole with water. Do not chew, crush, or break it. Mouth-dissolving tablet: Place the tablet on the tongue and let it dissolve or disintegrate in the mouth. The tablet should disintegrate completely within the mouth before you swallow it.Dispersible tablet: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the contents.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lupisulide Syrup

  • Diarrhoea
  • Nausea
  • Vomiting
  • Changes in hepatic enzymes

Drug Warnings

Please inform your doctor before starting Lupisulide Syrup if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery, heart disease, severe renal/hepatic impairment, or a history of allergy to any painkillers. Lupisulide Syrup is not recommended in case of alcoholism, drug addiction, coagulation problems, in children, pregnancy, and breastfeeding mothers.

Drug Interactions

Drug Interaction: Lupisulide Syrup may interact with respiratory medicines (theophylline), blood thinners (warfarin), antidiabetics (insulin), anti-epileptics (phenytoin), anti-cancer agents (methotrexate), immune system affecting medicines (cyclosporine), antacids, and anti-HIV (didanosine).

Drug-Food Interaction: Do not take it with dairy products like milk, yoghurt or calcium-fortified juices.

Drug-Disease Interaction: Lupisulide Syrup is not recommended for people with bleeding disorders, like haemophilia, von Willebrand disease, or low blood platelets.

Drug-Drug Interactions Checker List

  • THEOPHYLLINE
  • WARFARIN
  • INSULIN
  • PHENYTOIN
  • METHOTREXATE
  • CYCLOSPORINE
  • DIDANOSINE

Habit Forming

No

Diet & Lifestyle Advise

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat foods rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids such as soy, berries, broccoli, grapes and green tea help in reducing inflammation. 

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Avoid smoking and alcohol consumption.

Disease/Condition Glossary

Pain: Pain can be short-term (acute) or long-term (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone, or organs. Chronic pain lasts for longer duration; it is caused due to pathologies like nerve damage, osteoarthritis, and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury.

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Alcohol

Caution

Taking Lupisulide Syrup with alcohol may cause dizziness or drowsiness. So, avoid or limit the intake of alcoholic beverages with Lupisulide Syrup.

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Pregnancy

Unsafe

Use of Lupisulide Syrup during pregnancy is not recommended, especially during the last 3 months of pregnancy as it may harm the unborn baby.

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Breast Feeding

Unsafe

Use of Lupisulide Syrup during breastfeeding is not recommended as it may pass through the milk and harm the baby.

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Driving

Caution

Lupisulide Syrup may cause dizziness, sleepiness, and drowsiness. Drive only if you are alert.

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Liver

Unsafe

Lupisulide Syrup can cause hepatotoxicity (liver damage). So, it is not recommended in people with liver disease/impairment.

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Kidney

Caution

Lupisulide Syrup to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Lupisulide Syrup is contraindicated in children below 12 years of age. It may cause kidney problems in children and adolescents who are dehydrated.

Country of origin

India
Other Info - LU71094

Author Details

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FAQs

Lupisulide Syrup is used to relieve pain, including menstrual pain and dental pain.
Lupisulide Syrup works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in the body.Â
No, Lupisulide Syrup is not indicated for stomach pain. If you have stomach pain post-ingestion, it may be a sign of a stomach ulcer or gastric bleeding. Do not take Lupisulide Syrup in this condition. It is better to inform your doctor in case of stomach pain post-ingestion of this medication.
No, Lupisulide Syrup should not be taken as a long-term medication as it may lead to stomach ulcers/bleeding and kidney problems. Take Lupisulide Syrup in doses and duration mentioned by your doctor.
Yes, Lupisulide Syrup should preferably be taken with food to avoid an upset stomach. If taken on an empty stomach, it may cause stomach irritation and upset stomach.
Lupisulide Syrup may cause dizziness. If you feel dizzy, please rest and avoid driving as it can be harmful.
No, Lupisulide Syrup does not cause weight gain.
Lupisulide Syrup is not recommended for children below 12 years of age. If you have any concerns, consult a child's specialist before giving Lupisulide Syrup to your child.
Lupisulide Syrup may cause side effects such as nausea, vomiting, or diarrhoea. If these side effects persist or worsen, please consult your doctor.
Lupisulide Syrup is not an antibiotic. It belongs to the class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs; pain-relieving drug) which helps in relieving pain associated with several disease conditions.
You are not recommended to take Lupisulide Syrup with paracetamol as both the medicines belong to the same class known as non-steroidal anti-inflammatory drugs (NSAIDs) and taking them together may increase the risk of gastric ulceration and bleeding. However, please consult your doctor before using Lupisulide Syrup with other medicines.
Lupisulide Syrup does not contain aspirin. It contains Nimesulide.
Lupisulide Syrup is safe if used as per the dose and duration prescribed by your doctor.
You can take Lupisulide Syrup for headache only when advised by your doctor.
Lupisulide Syrup does not make you drowsy at prescribed doses. However, taking too much of Lupisulide Syrup can make you drowsy (feeling sleepy).
No, Lupisulide Syrup does not contain sulphur.
Lupisulide Syrup can be taken with ibuprofen. However, please consult your doctor before taking Lupisulide Syrup with other medicines to avoid drug interactions.
Lupisulide Syrup can be taken with aspirin. However, please consult your doctor before taking Lupisulide Syrup with other medicines to avoid drug interactions.
No, in India Lupisulide Syrup is not banned.
Lupisulide Syrup is usually not recommended during breastfeeding. Therefore, take your doctor’s advice before using Lupisulide Syrup if you are breastfeeding.
No, Lupisulide Syrup is not recommended during pregnancy especially in the last three months. There have been reports of kidney failure in new born babies if Lupisulide Syrup was used in the late stage of pregnancy. Consult your doctor before taking Lupisulide Syrup or any medicine during pregnancy.
Lupisulide Syrup is safe in asthma patients if taken as advised by your doctor. However, always inform your doctor about your disease history in case you have asthma and if you are taking other medicines.

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