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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lupidexa 4 mg Injection contains dexamethasone used to treat severe allergic conditions, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, etc. This medicine belongs to the corticosteroid class which works by inhibiting the production of certain chemical messengers in the body that cause inflammation. Thus, helps reduce swelling, redness, and itching.
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Composition :

DEXAMETHASONE-4MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lupidexa 4 mg Injection

Lupidexa 4 mg Injection is used to replace Dexamethasone deficiency. It treats various medical conditions, including severe allergic conditions, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, oedema, eye disorders, neoplastic states and endocrine disorders. It is also used in preoperative and postoperative support. Furthermore, it is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Lupidexa 4 mg Injection contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions, such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

Lupidexa 4 mg Injection will be administered by a healthcare professional; do not self-administer. Some people may experience mood changes in personality, mental health problems, muscle weakness, increased appetite, irregular or absent menstrual periods, infections and infestations, impaired vision, difficulty falling asleep or staying asleep, heartburn, peptic ulcer, muscle weakness, nausea and injection site pain or redness as side effects of Lupidexa 4 mg Injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Let your doctor know before prescribing Lupidexa 4 mg Injection if you are allergic to any content of this medicine or sulphites. Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine. Before obtaining the Lupidexa 4 mg Injection, notify your doctor about your medical history and any other medications you are currently taking to rule out any potentially harmful effects.

Uses of Lupidexa 4 mg Injection

Treatment of Allergic or inflammatory conditions and Covid-19

Directions for Use

Lupidexa 4 mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Lupidexa 4 mg Injection is a steroid (corticosteroids) medication. Corticosteroids occur naturally in the body and contribute to overall health and well-being. Increasing your body's corticosteroid levels (such as dexamethasone) is an effective strategy for treating various disorders involving inflammation. Lupidexa 4 mg Injection decreases inflammation, otherwise which might worsen your disease. You must take it daily to get the maximum benefits of Lupidexa 4 mg Injection.

How Lupidexa 4 mg Injection Works

Lupidexa 4 mg Injection contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions, such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lupidexa 4 mg Injection

  • Difficulty falling asleep or staying asleep

  • Mood changes in personality

  • Depression

  • Muscle weakness

  • Increased sweating

  • Increased appetite

  • Weight gain

  • Joint pain

  • Irregular or absent menstrual periods

  • Injection site pain or redness

  • Mental health problems

  • Infections and infestations

  • Abnormal growth of tissue

  • Abnormal increase in the number of white blood cells

  • Abnormal hair growth

  • Impaired vision

  • Vertigo (spinning sensation)

  • Headache

  • Cataracts or feeling increased pressure in the eye

  • Thickening of the heart muscle

  • High blood pressure

  • Blood clots in the veins

  • Nausea

  • Hiccups (sudden inspiration or intake of air)

  • Heartburn

  • Peptic ulcer

  • Muscle weakness

  • Loss of muscle mass

  • Osteoporosis (loss of bone density)

What if I have taken an overdose of Lupidexa 4 mg Injection

Lupidexa 4 mg Injection is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Abnormal heartbeats, epilepsy, and severe allergic reactions that manifest as breathing difficulties, hives, or tongue or throat swelling are the symptoms of overdose. Your doctor may take immediate necessary measures if an overdose is suspected.

Drug Warnings

Before prescribing Lupidexa 4 mg Injection, inform your doctor if you are allergic to any content of this medicine or other steroid medicines. You should disclose to your doctor if you have received any live virus vaccines. You should discuss with your doctor if you have fungal infections, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, TB, bacteraemia (viable bacteria in the bloodstream), joint, liver, kidney, or heart conditions and septic arthritis resulting from gonorrhoea or tuberculosis. If you are pregnant, planning for pregnancy or breastfeeding, inform your doctor before receiving this medicine. Contact your doctor immediately if you notice mood changes or have depression and strange thoughts while Lupidexa 4 mg Injection therapy.

Drug-Drug Interactions

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DexamethasoneRanolazine
Critical
DexamethasoneRilpivirine
Critical

Drug-Drug Interactions

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DexamethasoneRanolazine
Critical
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Lupidexa 4 mg Injection 30 ml is taken with Ranolazine, may significantly reduce the blood levels of Ranolazine.

How to manage the interaction:
Co-administration of Ranolazine and Lupidexa 4 mg Injection 30 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
DexamethasoneRilpivirine
Critical
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Rilpivirine is taken with Lupidexa 4 mg Injection 30 ml, may significantly reduce the blood levels of Rilpivirine.

How to manage the interaction:
Co-administration of Rilpivirine and Lupidexa 4 mg Injection 30 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
DexamethasoneDesmopressin
Critical
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Co-administration of Desmopressin with Lupidexa 4 mg Injection 30 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Lupidexa 4 mg Injection 30 ml and Desmopressin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DexamethasoneRegorafenib
Critical
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
When Regorafenib is taken with Lupidexa 4 mg Injection 30 ml, may significantly reduce the blood levels of Regorafenib.

How to manage the interaction:
Co-administration of Regorafenib and Lupidexa 4 mg Injection 30 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
DexamethasoneMifepristone
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Taking Lupidexa 4 mg Injection 30 ml with Mifepristone may significantly reduce the levels of Lupidexa 4 mg Injection 30 ml, which may make Lupidexa 4 mg Injection 30 ml less effective in treating your condition.

How to manage the interaction:
Co-administration of Lupidexa 4 mg Injection 30 ml with mifepristone can cause an interaction. However, they can be taken together if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
DexamethasoneBempedoic acid
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Co-administration of Bempedoic acid with Lupidexa 4 mg Injection 30 ml can result in tendinitis (a condition in which the tissue connecting muscle to bone becomes inflamed) and tendon rupture (injuries to the soft tissues that connect muscles and joints).

How to manage the interaction:
Although there is an interaction, Bempedoic acid can be taken with Lupidexa 4 mg Injection 30 ml if prescribed by the doctor. However, if you experience pain, inflammation, or swelling of a tendon area such as the back of the ankle, biceps, shoulder, hand, or thumb, stop taking bempedoic acid and consult a doctor. Exercise and using the impacted area should both be avoided. Do not discontinue the medication without consulting a doctor.
DexamethasoneOfloxacin
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Lupidexa 4 mg Injection 30 ml and Ofloxacin co-administration can result in tendinitis (inflammation of the thick fibrous cords that connect muscle to bone) and tendon rupture.

How to manage the interaction:
Taking Ofloxacin with Lupidexa 4 mg Injection 30 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience Stiff joints or difficulty moving your joints, joint pains, Swelling, or skin discoloration, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DexamethasoneAmiodarone
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Co-administration of Amiodarone with Lupidexa 4 mg Injection 30 ml may reduce Amiodarone's effects.

How to manage the interaction:
Despite the possibility of an interaction between Amiodarone and Lupidexa 4 mg Injection 30 ml, you can take them if prescribed by a doctor. Inform your doctor if you have an abnormal heartbeat or a racing heart. Do not discontinue any medications without consulting a doctor.
DexamethasoneAxitinib
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Taking Lupidexa 4 mg Injection 30 ml may reduce the blood levels of Axitinib, making the medication less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction, Lupidexa 4 mg Injection 30 ml can be taken with axitinib if prescribed by the doctor. Do not discontinue any medications without consulting a doctor.
DexamethasoneLevofloxacin
Severe
How does the drug interact with Lupidexa 4 mg Injection 30 ml:
Taking Levofloxacin with Lupidexa 4 mg Injection 30 ml can induce tendinitis(inflammation of the thick fibrous cords that attach muscle to bone. These cords are called tendons).

How to manage the interaction:
Concomitant administration of levofloxacin with Lupidexa 4 mg Injection 30 ml can result in an interaction, it can be taken if a doctor has advised it. If you experience pain, swelling, or inflammation in a tendon location such as the back of the ankle, shoulder, biceps, hand, or thumb, call a doctor immediately. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Lupidexa 4 mg Injection 30 ml with Caffeine may increase the side effects of Lupidexa 4 mg Injection 30 ml. Avoid consuming caffeine while taking Lupidexa 4 mg Injection 30 ml.

Diet & Lifestyle Advise

Diet & Lifestyle for Allergic or inflammatory conditions:

  • Consume antioxidant-rich food. Blueberries, tomatoes, cherries, squash, and bell peppers are highly antioxidants.

  • Consuming probiotic-rich foods aids in the development of the immune system's resistance to allergies.

  • Consume foods rich in quercetin (a flavonoid), such as apples, cherries, spinach, broccoli, and blueberries.

  • Include seasonal fruits, vegetables, whole grains, healthy fats, and fish in your daily diet.

  • Limit your intake of foods that may cause allergies, such as dairy products, soy, eggs, and nuts.

  • Limit the consumption of foods high in sugar that may aggravate inflammation.

  • Reducing stress and having a regular sleep schedule might be beneficial.

  • Avoid processed meats, refined carbohydrates, sugar, trans fats, and alcohol, as they may aggravate inflammation.

 

Diet & Lifestyle for Covid-19:

  • Remember always to wear a mask when you're around other people. Wearing a mask aids in the prevention of illness spread.

  • Take care of your mental health. Fear and anxiety can hamper the immune system as well. Therapy, yoga, and meditation effectively allow the mind a state of peace.

  • Keep a social distance and avoid social gatherings.

  • Please do not touch your eyes, nose or mouth if your hands are not clean.

  • Hands should be washed with soap and water or an alcohol-based sanitiser on a regular basis.

  • All surfaces should be cleaned and disinfected on a regular basis.

  • Gargling with salt water and inhaling steam would be beneficial.

  • Never exchange personal objects that have been contaminated with bodily fluids or blood, such as razor blades or toothbrushes.

  • Never share used needles and other injections or medical devices, as they may spread viruses.

  • Consume a well-balanced diet. Consume vitamin and nutrient-rich foods like dark green, yellow, orange, and red vegetables and fruits to enhance your immune system. Choose lean protein and whole carbohydrates over-processed foods.

  • Consume no raw meat or eggs. Consume boiled and cooked meat, poultry, or seafood.

  • If you have nausea or vomiting, eat bland, low-fat foods and avoid spicy or greasy foods.

  • Spending time with family or doing whatever makes you happy might help you minimise emotional and physical stress.

Habit Forming

No

Therapeutic Class

CORTICOSTEROIDS

Lupidexa 4 mg Injection Substitute

Substitutes safety advice
  • Decmax 4mg Tablet 8's

    by AYUR

    4.50per tablet
  • Auradex 4 mg Tablet 10's

    by AYUR

    3.96per tablet
  • Decmax 4 mg Tablet 4's

    4.40per tablet
  • Dexam 4 mg Tablet 4's

    3.83per tablet
  • Dexona Injection 1 x 2 ml

    9.90per tablet
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Alcohol

Caution

It is unknown whether alcohol interacts with Lupidexa 4 mg Injection. Please consult your doctor.

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Pregnancy

Caution

If you are pregnant, inform your doctor. Your doctor will then decide if the Lupidexa 4 mg Injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Breast Feeding

Caution

Inform your doctor if you are a nursing mother. The doctor will then decide if the injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Driving

Caution

Lupidexa 4 mg Injection may cause a reduction in mental awareness; thus, avoid operating machinery or driving.

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Liver

Caution

Inform your doctor before receiving the Lupidexa 4 mg Injection if you have a history of or ongoing liver disease. Your doctor will adjust the dose of this medicine if required based on your condition.

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Kidney

Caution

Inform your doctor before receiving the Lupidexa 4 mg Injection if you have a history of or ongoing kidney disease. Your doctor may carry out extra checks while you are taking this medicine.

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Children

Caution

Lupidexa 4 mg Injection may affect the growth of children. Therefore, your doctor may check the growth of the child regularly while using the Lupidexa 4 mg Injection.

FAQs

Lupidexa 4 mg Injection is used in conditions like severe allergy, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, oedema, eye disorders, neoplastic states and endocrine disorders.
Lupidexa 4 mg Injection contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.
If you are about to be vaccinated, especially if it is a live vaccine, inform your doctor that you are taking Lupidexa 4 mg Injection because taking Lupidexa 4 mg Injection and getting immunised at the same time is not recommended.
Lupidexa 4 mg Injection is not recommended to be used in fungal infections. If you have any concerns regarding this, please discuss them with your doctor.
Lupidexa 4 mg Injection may increase the risk of Infections and infestations. Therefore, it is advised to stay away from people having chickenpox (herpes simplex), shingles (herpes zoster) or measles.
Lupidexa 4 mg Injection is approved for the treatment of coronavirus disease 2019 (COVID-19) in adults and adolescents (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.
Caution is advised if you are taking anticoagulants while on Lupidexa 4 mg Injection treatment. Checking your blood clotting time is recommended to lessen the risk of bleeding.
Lupidexa 4 mg Injection should not be used in patients with systemic fungal infections, allergies to dexamethasone, or any other ingredients of medicine or patients who received live vaccines recently.
Lupidexa 4 mg Injection may cause side effects such as depression, muscle weakness, increased sweating, increased appetite, weight gain, joint pain, irregular menstrual periods, mental health problems, impaired vision, headache, nausea, high blood pressure, heart burns, peptic ulcers, and blood clots in veins. If these side effects persist or worsen, please consult your doctor.
Lupidexa 4 mg Injection may interact with other medicines such as phenytoin (anticonvulsants), aspirin (nonsteroidal anti-inflammatory drugs), rifampicin (antibiotic), warfarin (anticoagulant), ritonavir (antiretroviral drugs), and aminoglutethmide (anticancer). Therefore, consult your doctor before taking other medicines while on treatment with Lupidexa 4 mg Injection.
Store Lupidexa 4 mg Injection at room temperature. Protect from light. Keep it out of reach of children.
It is essential to regularly monitor your blood sugar levels, electrolytes, blood pressure, and bone density if you are using Lupidexa 4 mg Injection for long-term. Discuss with doctor for any further information.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - LUP0119

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