Lofen-SP Tablet belongs to the class of drugs known as 'non-steroidal anti-inflammatory drugs' (NSAID). It is a fixed-dose combination composed of aceclofenac, paracetamol and serratiopeptidase. Lofen-SP Tablet is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. Aceclofenac works by blocking the action of an enzyme known as cyclo-oxygenase (COX), which causes pain and swelling in the injured or damaged tissue. Paracetamol acts as a mild analgesic (pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of aceclofenac. Serratiopeptidase is an enzyme which helps in the breakdown of a protein (fibrin) which is formed as a by-product of the clotted blood at the site of injury. It thus causes thinning of the fluids around the site of injury thereby making fluid drainage smoother in the swollen tissue.

Pain can be temporary (acute) or lifelong (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone or organs. Chronic pain lasts for life and is caused by nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. There are different types of musculoskeletal pain caused due to soft tissue (muscle, tendon and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal. 

You can take Lofen-SP Tablet with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite or break it. Your doctor will advise you on how often you take your tablets based on your medical condition.  Most of the side effects of Lofen-SP Tablet do not require medical attention and gradually resolve over time. Common side effects include nausea, vomiting, indigestion, stomach pain, etc. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Do not take Lofen-SP Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children. It is advisable not to exceed the recommended dose or duration of treatment.

Lofen-SP Tablet consists of aceclofenac, paracetamol and serratiopeptidase. Aceclofenac works by blocking the action of an enzyme known as cyclo-oxygenase (COX), which causes pain and swelling in the injured or damaged tissue. Paracetamol acts as a mild analgesic (pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of aceclofenac. Serratiopeptidase causes thinning of the fluids around the site of injury, thereby making fluid drainage smoother in the swollen tissue. Together, these not only reduce pain and inflammation but also help with faster healing.

• Nausea
• Stomach Pain
• Loss of appetite
• Diarrhoea
• Stomach upset
• Indigestion

Consumption of alcohol should be avoided during the treatment with Lofen-SP Tablet as it may lead to an increase in the risk of liver damage. Patients with stomach ulcers, gastric bleeding, severe heart failure and liver or kidney disease should not take Lofen-SP Tablet on their own. Besides this, it should be avoided during the last trimester of pregnancy, unless there are compelling reasons for doing so. If you have a severe allergy to painkillers like asthma, rhinitis, angioedema (swelling under the skin) or skin rashes, immediately stop taking Lofen-SP Tablet . Use with caution in pregnancy and breastfeeding. Do not self-administer Lofen-SP Tablet if you are pregnant or are nursing.

Drug-Drug Interaction: Drugs containing pain killers (nimesulide, oxyphenbutazone, metamizole), and blood clotting agents (warfarin) should not be taken with Lofen-SP Tablet as they may interact.

Drug-Food Interaction: No interaction found.

Drug-Disease Interaction: Inform your doctor if you have peptic ulcer, gastric bleeding, severe heart failure, and high blood pressure before taking Lofen-SP Tablet .

• NIMESULIDE
• OXYPHENBUTAZONE
• METAMIZOLE
• WARFARIN

• Include more glucosamine, chondroitin sulphate, Vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.
• Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.
• In the chronic conditions of arthritis or joint pain try to include fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
• Your sitting posture is important especially when have pain and inflammation conditions. Try to sit as little as possible, and only for short time (10-15 min). Use back support like rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

• Paracetamol is a component of Lofen-SP Tablet which can cause liver injury when in taken in large doses (usually more than 4 g/day). Concomitant use of alcohol is best avoided as it aggravates the liver toxicity.
• Although Lofen-SP Tablet provides symptomatic relief in conditions like arthritis and may reduce the inflammation caused by these conditions, to achieve best results, it is strongly recommended remaining physically active as much as your condition allows. Adopting a healthy lifestyle coupled with healthy diet containing high proteins, is the mainstay of management of arthritic conditions.

Pain can be temporary (acute) or lifelong (chronic) in nature. Acute pain is for a short time, caused by damage to the tissues of the muscle, bone or organs. Chronic pain lasts for life and is caused by nerve damage, osteoarthritis, and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury. There are different types of musculoskeletal pain caused due to soft tissue (muscle, tendon and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.