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Written By , M Pharmacy
Reviewed By , MPharma., PhD
Last Updated Jan 1, 2025 | 9:31 AM IST

Lifokinase 750000IU Injection is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis. Lifokinase 750000IU Injection contains Streptokinase, which works by dissolving the harmful blood clots in the blood vessels; this restores the blood flow to the affected tissue, thereby preventing tissue death and improving outcomes.

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Prescription drug

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Manufacturer/Marketer :

Shasun Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Lifokinase 750000IU Injection

Lifokinase 750000IU Injection belongs to the class of medicines called antifibrinolytic agents. It is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis.

Lifokinase 750000IU Injection contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.

Lifokinase 750000IU Injection should be administered to patients only in a hospital setting by an experienced healthcare professional. Lifokinase 750000IU Injection may cause certain common side effects, including allergic reactions, hypotension, tachycardia, bradycardia, hypotension, heart rate and rhythm disorders, angina pectoris, nausea, diarrhoea, epigastric pain, vomiting, headache, back pain, musculoskeletal pain, chills, fever, asthenia, elevations of serum transaminases and bilirubin. These side effects usually go away on their own. If you develop any other serious side effects, such as vision problems while using Lifokinase 750000IU Injection, consult your doctor immediately.

Lifokinase 750000IU Injection is indicated in adults. Lifokinase 750000IU Injection is not recommended for children below 18 years of age as the safety and effectiveness were not established. Inform your doctor if you are pregnant or planning for pregnancy or breastfeeding since Lifokinase 750000IU Injection is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy. It is unknown whether Streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

Uses of Lifokinase 750000IU Injection

Used to dissolve blood clots that have formed in the blood vessels and Treatment of Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous, and Arterial thrombosis

Medicinal Benefits

Lifokinase 750000IU Injection contains ‘Streptokinase’, which belongs to the class of anti-fibrinolytic agents. It acts by regulating the breakdown of blood clots in the body. It blocks the release and action of plasmin, an enzyme essential for the breakdown of clots in the blood. This effect helps to slow down abnormal bleeding.

Side Effects of Lifokinase 750000IU Injection

  • Haemorrhage at the injection site
  • Ecchymoses (a discoloration of the skin)
  • Gastrointestinal bleeding
  • Genitourinary bleeding
  • Epistaxis (nosebleed)
  • Development of anti-streptokinase antibodies
  • Allergic reactions
  • Hypotension
  • Tachycardia
  • Bradycardia
  • Hypotension
  • Heart rate and rhythm disorders
  • Angina pectoris
  • Nausea
  • Diarrhoea
  • Epigastric pain
  • Vomiting
  • Headache
  • Back pain
  • Musculoskeletal pain
  • Chills
  • Fever
  • Asthenia (abnormal physical weakness)
  • Elevations of serum transaminases and bilirubin

Directions for Use

Lifokinase 750000IU Injection will be given to you by your healthcare professional.

Drug Warnings

Before taking Lifokinase 750000IU Injection, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Usage of Lifokinase 750000IU Injection contraindicated to use in persons with certain medical conditions that cause risk of bleeding such as existing or recent internal haemorrhage (internal bleeding), recent cerebrovascular accident, intracranial or intraspinal surgery, intracranial neoplasm (brain tumour), recent head trauma, arteriovenous malformation (an abnormal connection between arteries and veins), neoplasm  (a cancerous tumour) with risk of bleeding, pancreas inflammation, severe liver or kidney damage and simultaneous or recent treatment with oral anticoagulants. So, let your doctor know about all your medical conditions, sensitivities, and all medications you are using.

Therapeutic Class

ANTIFIBRINOLYTIC AGENTS

Diet & Lifestyle Advise

  • Ask your doctor about the preferred exercises to do based on your health condition.
  • Stay hydrated and consume plenty of fluids. Fluids are necessary to maintain blood flow in your body.
  • Consume fresh fruits and vegetables. Consult a dietitian and prepare a diet plan. Eating healthy can help you to recover faster.

Habit Forming

No

How Lifokinase 750000IU Injection Works

Lifokinase 750000IU Injection contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.

What if I have taken an overdose of Lifokinase 750000IU Injection

As Lifokinase 750000IU Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.
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Alcohol

Caution

Lifokinase 750000IU Injection may not interact with alcohol. However, avoid the consumption of alcohol as it may worsen your health condition.

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Pregnancy

Caution

Lifokinase 750000IU Injection is contra-indicated in pregnancy, especially within the first 18 weeks of pregnancy.

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Breast Feeding

Caution

It is unknown whether streptokinase is excreted in human milk. Breast milk should be discarded during the first 24 hours following thrombolytic therapy.

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Driving

Caution

It is not known whether Lifokinase 750000IU Injection alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Inform your doctor before receiving Lifokinase 750000IU Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving Lifokinase 750000IU Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Lifokinase 750000IU Injection is not recommended in neonates, infants and children.

Country of origin

India
Other Info - LI97786

Author Details

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FAQs

Lifokinase 750000IU Injection is used to dissolve blood clots that have formed in the blood vessels in various conditions such as Intravascular dissolution of thrombi and emboli in extensive deep vein thrombosis, Pulmonary embolism, Acute or subacute occlusion of peripheral arteries, Central retinal venous and Arterial thrombosis.
Lifokinase 750000IU Injection contains Streptokinase. Streptokinase creates a highly specific 1:1 enzymatic complex with plasminogen that transforms inactive plasminogen molecules into active plasmin. Plasmin destroys fibrin clots, as well as fibrinogen and other plasma proteins. This, in turn, causes the breakdown of blood clots.
Lifokinase 750000IU Injection may cause Arrhythmia. Arrhythmia monitoring is advised during and soon following delivery of Streptokinase.
The most frequent adverse reaction associated with this therapy is bleeding. In most cases, this condition gradually resolves over time. However, if bleeding persists, contact your doctor.
Do not take anticoagulants; drugs that inhibit platelet function increase the risk of bleeding when administered Lifokinase 750000IU Injection.
Lifokinase 750000IU Injection may cause side effects in some individuals. Commonly reported side effects include allergic reactions, fluctuations in blood pressure and heart rate, chest pain, gastrointestinal issues like nausea and diarrhea, muscle pain, headache, chills, fever, and general weakness. Additionally, it may occasionally affect liver function, leading to elevated serum transaminase and bilirubin levels. Most side effects are temporary and resolve without needing further treatment. However, if you experience severe side effects, such as vision problems, seek immediate medical attention for proper evaluation and guidance.

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