Legestro 250 Injection belongs to the category of a synthetic progesterone female hormone called progestin used to prevent premature labour. Premature labour can start before 37 completed weeks of pregnancy and can be caused by premature rupture of membranes, high blood pressure during pregnancy (pre-eclampsia), and poor diet. Preterm labour symptoms include leaking fluid or bleeding from the vagina, the feeling of pressure in the pelvis, and cramps that feel like menstrual cramps regularly.

Legestro 250 Injection contains 'Hydroxyprogesterone', a progestin (female hormones) that modulates the immune response of pregnant women to prevent rejection of the embryo and allow its attachment to the uterus. Legestro 250 Injection prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had past premature labour. Legestro 250 Injection should be administered only to those pregnant women who are pregnant with one baby or who have had a preterm (premature) delivery of one baby in the past.

Legestro 250 Injection will be administered by a healthcare professional. Do not self-administer. In some cases, you may experience certain common side effects such as nausea, vomiting, itching, hives (skin rashes), swelling in the face, lips, tongue, or throat, and diarrhoea. Not everybody experiences these side effects. Most of the side effects of Legestro 250 Injection do not require medical attention and gradually resolve over time. Talk to your doctor if you feel any discomfort while taking Legestro 250 Injection.

Before starting Legestro 250 Injection, please inform your doctor if you have an allergy to any medicines, have unusual vaginal bleeding related to your pregnancy, liver disease, severe hypertension (high blood pressure), or a history of breast cancer, uterus or vagina. Tell your doctor before using Legestro 250 Injection if you have had pre-eclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clot form in the blood), diabetes, depression, or epilepsy. Legestro 250 Injection may cause dizziness, so be cautious while driving and operating machinery. Avoid alcohol consumption to prevent unpleasant side effects. Inform your doctor about all medicines you are taking and about your health condition to rule out any unpleasant side effects.

Legestro 250 Injection contains “Hydroxyprogesterone” a progestin (female hormones) that is used in pregnant women who have delivered a baby too early (preterm) in the past. It works by modulating the immune response of pregnant women to prevent the rejection of the embryo and allow its attachment to the uterus. Legestro 250 Injection prevents miscarriage and helps lower the risk of premature birth in pregnant women who have had a past premature delivery.

• Nausea
• Vomiting
• Itching
• Hives (skin rashes)
• Swelling in the face, lips, tongue, or throat
• Diarrhea

You should not take Legestro 250 Injection without a doctor's advice. Before starting Legestro 250 Injection, please inform your doctor if you have an allergy to any medicines. Do not take Legestro 250 Injection if you have unusual vaginal bleeding that is not related to your pregnancy, liver disease, severe hypertension (high blood pressure), or history of cancer of the breast, uterus or vagina. Tell your doctor before using Legestro 250 Injection if you have had preeclampsia (high blood pressure during pregnancy), thromboembolic disorders (blood clot form in the blood), diabetes, depression, or epilepsy. Do not take Legestro 250 Injection on your own. Legestro 250 Injection can cause dizziness and drowsiness. Use caution while driving a motor vehicle, as dizziness or drowsiness may occur. Let your doctor know if you are a breastfeeding mother. Your doctor will weigh the benefits and any potential risks before prescribing them to you. Legestro 250 Injection is not recommended for children younger than 16 years old. Legestro 250 Injection is not intended for use in the first trimester of pregnancy.

Drug-Drug interaction: This Legestro 250 Injection interacts with pain killers (acetaminophen) anti-epilepsy medicines (primidone, phenytoin, carbamazepine), antidiabetics (metformin, glimepiride, glipizide, canagliflozin), medicines used to treat HIV (efavirenz) medicine used to treat fungal infections (griseofulvin, ketoconazole, itraconazole, posaconazole).

Drug-Food Interaction: Legestro 250 Injection may interact with grapefruit and alcohol. 

Drug-Disease Interaction: Legestro 250 Injection should be taken with caution in breast cancer, thromboembolism (blood clot form in blood vessels), depression, diabetes, fluid retention (excess fluid builds up within the body), and kidney or liver disease.

• ACETAMINOPHEN
• PRIMIDONE
• PHENYTOIN
• CARBAMAZEPINE
• METFORMIN
• GLIMEPIRIDE
• GLIPIZIDE
• CANAGLIFLOZIN
• EFAVIRENZ
• GRISEOFULVIN
• KETOCONAZOLE
• POSACONAZOLE

• Eat a healthy and balanced diet rich in vegetables, fruits, and whole grains to reduce the risk of preterm delivery.
• Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil.
• I prefer whole foods and grains to processed ones. I avoid processed foods and foods high in sugar and fat.
• Avoid stress, as it can increase the chances of preterm delivery. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
• Regular physical activity and yoga keep you fit, help improve blood circulation, and regulate the oxygen supply, thereby improving your chances of carrying your baby full term.
• Quitting smoking is the best strategy to lower the risk of premature delivery.
• Keep your weight under control.
• Try to avoid alcohol as it can affect your stomach and intestine and limit the absorption of the important nutrients required by your body.

• You should not be treated with Legestro 250 Injection if you are allergic to hydroxyprogesterone or castor oil.
• Legestro 250 Injection is not recommended for use in women less than 16 years of age.
• Legestro 250 Injection will not stop premature labour in the women in whom it has already begun.
• Legestro 250 Injection is for women pregnant with only 1 child and not for use in women who are pregnant with more than one baby (twins, triplets, etc).

Preterm labour: Preterm labour, also called premature labour, is when your baby starts getting ready for birth too early in your pregnancy. It can start before 37 completed weeks of pregnancy. Premature labour can be caused by premature rupture of membranes, high blood pressure during pregnancy (pre-eclampsia), and poor diet. Symptoms of preterm labour include leaking fluid or bleeding from the vagina, the feeling of pressure in the pelvis, and cramps that feel like menstrual cramps regularly. Few premature babies need special care and also have long-term mental and physical disabilities.