Leevarin 15 Tablet 10's belongs to the class of medicines known as folic acid analogues (a form of vitamin B). It is primarily used to treat an overdose of methotrexate (cancer medicine). It is used to prevent the harmful effects of methotrexate. Methotrexate is used to treat cancer, severe rheumatoid arthritis, and severe psoriasis. It can cause side effects like swollen gums, headaches, hair loss, dizziness, etc. Infrequently, it can cause fatal side effects. Harmful effects of methotrexate include vision loss, seizures/ fits, loss of consciousness, etc. It can damage the blood, liver, bone marrow, lungs, etc. The drug can lead to birth defects and death in unborn babies.

Leevarin 15 Tablet 10's contains leucovorin, which is a form of vitamin B. It is folic acid in its active form. Leevarin 15 Tablet 10's works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells. It should be administered as soon as possible after taking methotrexate.

Take Leevarin 15 Tablet 10's as prescribed by your doctor. Depending on your medical conditions, you are advised to take Leevarin 15 Tablet 10's for as long as your doctor prescribes it. You may experience infections, nausea, vomiting, diarrhoea, and constipation. Most of these side effects of Leevarin 15 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Before taking the Leevarin 15 Tablet 10's, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding or if you have anaemia, GI toxicity, renal impairment and seizures.

Leevarin 15 Tablet 10's is used to prevent the harmful effects of methotrexate (cancer medicine) when methotrexate is used to treat some types of cancer. Leevarin 15 Tablet 10's is also used to treat patients who accidentally overdose on methotrexate or similar medicines. Leevarin 15 Tablet 10's works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells.

• Infections

• Nausea

• Vomiting

• Diarrhoea

• Constipation

Inform your doctor about any allergic or hypersensitive reactions to medications or food before taking the Leevarin 15 Tablet 10's. Inform your doctor about your medical history and any other medications you are currently taking so that any potential side effects can be ruled out. Also, let your doctor know if you are pregnant, intend to become pregnant, or are breastfeeding. Do not use Leevarin 15 Tablet 10's in more than prescribed doses or longer duration as it may cause adverse effects.

Drug-Drug Interactions: Leevarin 15 Tablet 10's may interact with anticancer medicines (e..g fluorouracil, capecitabine, pafolacianine) and antibiotics (e.g. trimethoprim, ceftriaxone).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Leevarin 15 Tablet 10's may interact with disease conditions, including anaemia, GI toxicity, renal impairment and seizures.

• FLUOROURACIL
• CAPECITABINE
• PHENOBARBITAL
• PHENYTOIN
• PRIMIDONE
• TRIMETHOPRIM
• CEFTRIAXONE

• Create a well-balanced and healthy diet that includes vegetables, fruits, whole grains, legumes, omega-3-rich foods, and lean protein sources.

• Keep your weight under control with a BMI of 19.5-24.9.

• Avoid chronic stress.

• Limit or avoid alcohol consumption.

• Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

• Inform your doctor if you are also taking certain medicines like phenytoin for your fits disorder, as Leevarin 15 Tablet 10's may reduce the antiepileptic effects.

Harmful effects of methotrexate: Methotrexate is used to treat cancer, severe rheumatoid arthritis, and severe psoriasis. It can cause side effects like swollen gums, headache, hair loss, dizziness, etc. Infrequently, it can cause fatal side effects. Harmful effects of methotrexate include vision loss, seizures/ fits, loss of consciousness, etc. It can damage the blood, liver, bone marrow, lungs, etc. The drug can lead to birth defects and death in unborn babies.