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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lastet 50 Capsule is used to treat various types of cancer, including testicular cancer, small cell lung cancer, blood cancer, ovarian cancer, and lymphoma. It contains Etoposide which works by preventing the growth and spread of cancer cells. In some cases, this medicine may cause side effects such as temporary hair loss, nausea and vomiting, loss of appetite, diarrhoea, and irregular heartbeat. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

ETOPOSIDE-50MG

Manufacturer/Marketer :

Khandelwal Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Lastet 50 Capsule

Lastet 50 Capsule belongs to a class of chemotherapy drugs primarily used to treat various types of cancer. It is used to treat testicular cancer, small cell lung cancer, cancer of the blood (acute myeloid leukaemia), ovarian cancer, and tumour in the lymphatic system (Hodgkin’s lymphoma, non-Hodgkin’s lymphoma). Cancer is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are many types of cancer, including blood, lung, breast, etc.

Lastet 50 Capsule contains Etoposide, which is primarily used to treat various types of cancers. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Take Lastet 50 Capsule with a glass of water on an empty stomach or as directed by your doctor. Depending upon your medical condition, you are advised to take Lastet 50 Capsule for as long as your doctor has prescribed it for you. Sometimes, you may experience temporary hair loss, nausea and vomiting, loss of appetite, diarrhoea, irregular heartbeat, and skin problems such as itching or rash. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lastet 50 Capsule if you are allergic to Lastet 50 Capsule or its ingredients. While taking Lastet 50 Capsule, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF). Regular blood tests are required to monitor liver function and blood cells in the blood while taking Lastet 50 Capsule. Do not take Lastet 50 Capsule if you have recently been given a live vaccine if you are breastfeeding or planning to breastfeed.

Uses of Lastet 50 Capsule

Treatment of Cancer (testicular cancer, small cell lung cancer, cancer of the blood, ovarian cancer, tumour in the lymphatic system).

Directions for Use

Swallow the whole tablet with a glass of water. Do not crush, chew or break it. Do not use this tablet if it has been accidentally broken, and using medicine from a broken tablet can be dangerous if it gets into the eyes, mouth, or nose.

Medicinal Benefits

Lastet 50 Capsule belongs to a class of chemotherapy drugs containing Etoposide primarily used to treat various cancer types. It is used to treat testicular cancer, small cell lung cancer, cancer of the blood, ovarian cancer, tumor in the lymphatic system. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

How Lastet 50 Capsule Works

Lastet 50 Capsule contains Etoposide, which is primarily used to treat various types of cancers. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lastet 50 Capsule

  • Temporary hair loss
  • Abdominal pain
  • Nausea and vomiting
  • Constipation
  • Dizziness
  • Blood disorders (this is why you will be having blood tests between courses of treatment)
  • Loss of appetite
  • Damage to the liver (hepatotoxicity)
  • Liver enzymes
  • Changes in skin colour (pigmentation)
  • Jaundice (increased bilirubin)
  • Feeling weak (asthenia)
  • Generally feeling unwell (malaise)

What if I have taken an overdose of Lastet 50 Capsule

Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Lastet 50 Capsule if you are allergic to Lastet 50 Capsule or its ingredients. Inform your doctor before taking Lastet 50 Capsule if you have active infections or low levels of a protein called albumin in blood, liver, or kidney problems. Lastet 50 Capsule may cause blurry vision and dizziness, so do not drive or operate machinery requiring concentration. While taking Lastet 50 Capsule, you might become more sensitive to sunlight, so it is important to protect your skin with a high sun protection factor (SPF) while going out, as it can lead to a skin rash if you are not using a strong SPF. Lastet 50 Capsule can cause a reduction in some blood cells, which may make you more susceptible to infections; consult your doctor if you develop any signs of infections. You will need to take regular blood tests during treatment with this medicine. If you have reduced kidney or liver function, your doctor may also advise taking regular blood tests while on this medication. Before taking Lastet 50 Capsule, inform your doctor, especially if you are on a drug such as cisplatin (a medicine used to treat cancer), live vaccines, warfarin (a medicine used to prevent blood clots), and drugs used to treat epilepsy. Lastet 50 Capsule is not recommended to be used during pregnancy or breastfeeding unless indicated by the doctor. Do not have a 'live' vaccine while using this medication, as it may not work as well during this time. Inform your doctor immediately if you notice sudden chest pain, discomfort, seizure (convulsions), or unusual bleeding (nose, mouth, vagina, or rectum).

Drug-Drug Interactions

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EtoposideRotavirus vaccine
Critical
EtoposideFingolimod
Severe

Drug-Drug Interactions

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EtoposideRotavirus vaccine
Critical
How does the drug interact with Lastet 50 Capsule 8's:
When the Rotavirus vaccine is used together with Lastet 50 Capsule 8's, it may not work as well.

How to manage the interaction:
Taking Lastet 50 Capsule 8's with the Rotavirus vaccine can cause an, please consult doctor before taking it. You may be at risk of acquiring an infection from the vaccination or having a decreased response of the vaccine depending on the dose and length of time you have been on Lastet 50 Capsule 8's. Do not discontinue any medications without a doctor's advice.
EtoposideFingolimod
Severe
How does the drug interact with Lastet 50 Capsule 8's:
When Lastet 50 Capsule 8's is used with Fingolimod, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Lastet 50 Capsule 8's with Fingolimod together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideInfliximab
Severe
How does the drug interact with Lastet 50 Capsule 8's:
When Infliximab is taken with Lastet 50 Capsule 8's, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Lastet 50 Capsule 8's with Infliximab can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
EtoposideCladribine
Severe
How does the drug interact with Lastet 50 Capsule 8's:
Taking Cladribine with Lastet 50 Capsule 8's can increase the risk of serious infections.

How to manage the interaction:
Taking Lastet 50 Capsule 8's with Cladribine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, make sure to contact the doctor right away. Do not stop using any medications without a doctor's advice.
EtoposideTeriflunomide
Severe
How does the drug interact with Lastet 50 Capsule 8's:
When Lastet 50 Capsule 8's is used with Teriflunomide, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Lastet 50 Capsule 8's with Teriflunomide can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideIdelalisib
Severe
How does the drug interact with Lastet 50 Capsule 8's:
When Lastet 50 Capsule 8's is used with Idelalisib, Idelalisib may increase the blood levels and effects of Lastet 50 Capsule 8's.

How to manage the interaction:
Taking Lastet 50 Capsule 8's with Idelalisib together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EtoposideGolimumab
Severe
How does the drug interact with Lastet 50 Capsule 8's:
When Lastet 50 Capsule 8's is used with Golimumab, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Lastet 50 Capsule 8's and Golimumab, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideLeflunomide
Severe
How does the drug interact with Lastet 50 Capsule 8's:
When Lastet 50 Capsule 8's is used with Leflunomide, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Leflunomide and Lastet 50 Capsule 8's, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EtoposideNatalizumab
Severe
How does the drug interact with Lastet 50 Capsule 8's:
Taking Lastet 50 Capsule 8's with natalizumab, especially taking both simultaneously with little to no time in between, may raise the risk of serious infections.

How to manage the interaction:
Although taking Lastet 50 Capsule 8's and Natalizumab together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor immediately, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. progressive weakening on one side of your body, clumsiness of limbs, visual disturbance, disorientation, or changes in your thinking, memory, or personality. Do not stop using any medications without talking to a doctor.
EtoposideDeferiprone
Severe
How does the drug interact with Lastet 50 Capsule 8's:
Co-administration of Lastet 50 Capsule 8's with deferiprone can cause a decrease in white blood cell count, and taking it with Lastet 50 Capsule 8's, which can similarly alter white blood cell count or bone marrow function, may enhance the risk. As a result, you may be more susceptible to serious infections.

How to manage the interaction:
There may be a possibility of interaction between Lastet 50 Capsule 8's and Deferiprone, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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ETOPOSIDE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ETOPOSIDE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit

How to manage the interaction:
Consumption of Grapefruit, grapefruit juice with Lastet 50 Capsule 8's, blocks metabolism, which might raise Lastet 50 Capsule 8's levels in the blood. Avoid the consumption of grapefruit juice while taking Lastet 50 Capsule 8's.

Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, and high fibre content. Also, eat small and frequent meals for a speedy recovery.
  • Avoid smoking and alcohol consumption. Also, avoid high fat and cholesterol diet.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Lastet 50 Capsule Substitute

Substitutes safety advice
  • Posid 50 mg Capsule 8's

    57.04per tablet
  • Etovel 50 mg Capsule 8's

    56.81per tablet
  • ETOPA 50MG TABLET

    53.55per tablet
  • Etoplast-50 Capsule 12's

    48.71per tablet
  • Etoposide 50 mg Capsule 8's

    6.36per tablet
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Alcohol

Caution

Avoid alcohol consumption while taking Lastet 50 Capsule as it may increase drowsiness and lead to unpleasant side effects.

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Pregnancy

Caution

Lastet 50 Capsule is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Lastet 50 Capsule and your next pregnancy.

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Breast Feeding

Caution

Lastet 50 Capsule is known to pass through breast milk, and it may cause harm to the baby. So, it is advised not to breastfeed while taking Lastet 50 Capsule.

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Driving

Caution

Lastet 50 Capsule may cause weakness, dizziness, and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Lastet 50 Capsule are not known in children. It should be taken only if prescribed by a doctor.

FAQs

Lastet 50 Capsule is used to treat testicular cancer, small cell lung cancer, cancer of the blood (acute myeloid leukaemia), ovarian cancer, and tumour in the lymphatic system (Hodgkin's lymphoma, non-Hodgkin's lymphoma).
Do not stop taking Lastet 50 Capsule on your own. You are advised to take Lastet 50 Capsule for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be hesitant to speak with your doctor if you experience any difficulty while taking Lastet 50 Capsule.
Lastet 50 Capsule contains Etoposide, an anti-cancer medication that works by inhibiting an enzyme responsible for the proliferation of cancer cells and hence induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.
While taking Lastet 50 Capsule, make sure you visit your doctor at all the appointments to ensure that treatment is working. Regular monitoring of blood and urine tests, weight checks are required. An effective way of contraception should be used by both men and women while taking Lastet 50 Capsule.
Lastet 50 Capsule can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.
The live vaccine may not work while on treatment with Lastet 50 Capsule. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Country of origin

India

Manufacturer/Marketer address

Khandelwal Laboratories Pvt. Ltd, 79/87 D.Ladpath, Mumbai 400 033, India.
Other Info - LAS0106

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