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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 23, 2024 | 4:31 PM IST
Kofnoril-DX Syrup Sugar Free is a combination medicine which belongs to the class of expectorants. It is used in the treatment of dry cough. This medicine works by preventing nerve signals from the brain's cough centre from reaching the muscles that cause coughing and thus reduce cough. You may experience common side effects like headache, dizziness, numbness, drowsiness, or nausea.
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About Kofnoril-DX Syrup Sugar Free

Kofnoril-DX Syrup Sugar Free belongs to a class of medication called 'cough and cold preparations' primarily used to treat dry cough. Coughing (dry or productive) is the body's way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. There are two types of coughs, namely, dry cough and chesty cough. A dry cough is tickly and doesn't produce any vicious or thick mucus, while a chesty cough (wet cough) produces mucous or sputum.

Kofnoril-DX Syrup Sugar Free contains Chlorpheniramine maleate, Phenylephrine and Dextromethorphan hydrobromide. Chlorpheniramine maleate works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps shrink the blood vessels located in the nasal passage, thereby reducing the stuffy nose. Dextromethorphan hydrobromide works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Together, Kofnoril-DX Syrup Sugar Free helps provide relief from dry cough.

Your doctor will recommend the dose and duration of Kofnoril-DX Syrup Sugar Free based on your medical condition. Some people may experience dry mouth/throat/nose, drowsiness, blurred vision, constipation, dizziness, restlessness or excitation. Most of these side effects of Kofnoril-DX Syrup Sugar Free do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Consult your doctor if you are pregnant or breastfeeding. Kofnoril-DX Syrup Sugar Free is not recommended for children below 12 years of age. If you are about to undergo medical tests or surgery, please inform your doctor that you are taking Kofnoril-DX Syrup Sugar Free. Kofnoril-DX Syrup Sugar Free may cause dizziness, so drive or operate machinery only if you are alert. Avoid alcohol consumption as it may cause increased dizziness. Keep your doctor informed about your health condition and medications to rule out any interactions/side effects.

Uses of Kofnoril-DX Syrup Sugar Free

Treatment of Dry cough

Medicinal Benefits

Kofnoril-DX Syrup Sugar Free is a combination medicine belonging to a class of drugs called 'cough and cold preparations' primarily used to treat dry cough. Chlorpheniramine maleate works by blocking the action of histamine, a substance responsible for causing allergic reactions. It helps relieve allergy symptoms such as sneezing, running nose, watery eyes, itching, swelling, congestion or stiffness. Phenylephrine is a decongestant that helps shrink the blood vessels located in the nasal passage, thereby reducing the stuffy nose. Dextromethorphan hydrobromide works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough. Thus, Kofnoril-DX Syrup Sugar Free helps relieve cough, cold and allergic symptoms.

Directions for Use

Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Kofnoril-DX Syrup Sugar Free

  • Dry mouth, throat or nose
  • Drowsiness
  • Dizziness
  • Blurred vision
  • Headache
  • Constipation
  • Restlessness or excitation
  • Loss of appetite

Drug Warnings

If you are allergic to Kofnoril-DX Syrup Sugar Free or any other medicines, please tell your doctor. Consult your doctor if you are pregnant or breastfeeding. Kofnoril-DX Syrup Sugar Free is not recommended for children below 12 years of age. Avoid taking Kofnoril-DX Syrup Sugar Free if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days. Inform your doctor if you have glaucoma, urinary problems, enlarged prostate, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), cough with mucus or cough caused by asthma, smoking, chronic bronchitis or emphysema (a lung condition causing shortness of breath).

Drug Interactions

Drug-Drug Interaction: Kofnoril-DX Syrup Sugar Free may interact with anti-allergic drugs (diphenhydramine), anti-psychotic (escitalopram, desvenlafaxine, vilazodone), pain killer (aspirin), cold medicines (acetaminophen), antibiotics (amoxicillin), anti-depressants (linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine), beta-blockers (metoprolol, atenolol), muscle relaxants (carisoprodol, cyclobenzaprine).

Drug-Food Interaction: No interactions found/established.

Drug-Disease Interaction: Inform your doctor if you have liver or kidney disease, asthma, diabetes, glaucoma, cardiovascular diseases, enlarged prostate gland, chronic bronchitis or emphysema (a lung condition causing shortness of breath).

Drug-Drug Interactions Checker List

  • DIPHENHYDRAMINE
  • ESCITALOPRAM
  • DESVENLAFAXINE
  • VILAZODONE
  • ASPIRIN
  • ACETAMINOPHEN
  • AMOXICILLIN
  • LINEZOLID
  • PHENELZINE
  • SELEGILINE
  • RASAGILINE
  • ISOCARBOXAZID
  • TRANYLCYPROMINE
  • METOPROLOL
  • ATENOLOL
  • CARISOPRODOL
  • CYCLOBENZAPRINE

Habit Forming

No

Diet & Lifestyle Advise

  • Avoid dairy products such as milk as it may increase mucus production. Also, avoid processed or refined foods. 

  • Drink plenty of fluids to avoid a dry throat. It also helps loosen mucus.

  • Avoid citrus fruits as they may worsen the cough.

  • Eat fruits rich in water content, such as pears, watermelon, peaches and pineapples.

Special Advise

  • Talk to your doctor if your symptoms do not improve even after taking Kofnoril-DX Syrup Sugar Free for 7 days.
  • Contact a doctor immediately if you develop fever, rash or headache after taking Kofnoril-DX Syrup Sugar Free. 
  • If you are about to undergo any medical tests or surgery, please inform your doctor that you are taking Kofnoril-DX Syrup Sugar Free.

Disease/Condition Glossary

Cough: Coughing is the body's way of clearing irritants (like allergens, mucus or smoke) from airways and preventing infection. Cough may be dry or productive. A productive cough (wet cough) brings up sputum (phlegm, mucus and other matter) from the lungs. A dry cough does not produce sputum. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an infection in the respiratory tract. 

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Alcohol

Caution

Avoid consumption of alcohol with Kofnoril-DX Syrup Sugar Free as it may increase drowsiness. Please consult a doctor before consuming alcohol with Kofnoril-DX Syrup Sugar Free.

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Pregnancy

Caution

The safety of Kofnoril-DX Syrup Sugar Free in pregnant women is unknown. Consult your doctor if you have any concerns; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Kofnoril-DX Syrup Sugar Free is excreted in human milk. Consult your doctor if you have any concerns; your doctor will decide if Kofnoril-DX Syrup Sugar Free can be taken by breastfeeding mothers or not.

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Driving

Caution

Kofnoril-DX Syrup Sugar Free may cause dizziness or drowsiness in some people. Therefore, drive only if you are alert after taking Kofnoril-DX Syrup Sugar Free.

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Liver

Caution

Take Kofnoril-DX Syrup Sugar Free with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Kofnoril-DX Syrup Sugar Free with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Kofnoril-DX Syrup Sugar Free is not recommended for children below 12 years of age. However, please consult a doctor if you have any concerns.

Country of origin

India
Other Info - KOFN624

Author Details

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FAQs

Kofnoril-DX Syrup Sugar Free is used to treat dry cough. It helps relieve cough, cold, and allergic symptoms.
Kofnoril-DX Syrup Sugar Free contains Chlorpheniramine maleate, Phenylephrine, and Dextromethorphan hydrobromide. Chlorpheniramine maleate works by blocking the action of histamine, a substance responsible for causing allergic reactions. Phenylephrine helps in shrinking the blood vessels located in the nasal passage, thereby reducing the stuffy nose. Dextromethorphan hydrobromide works by blocking the transmission of nerve signals from the cough centre in the brain to the muscles that produce cough.
Consult your doctor before taking Kofnoril-DX Syrup Sugar Free if you need to undergo surgery as it may lead to excessive drowsiness and sleepiness when given along with anaesthesia. Your doctor may advise you to stop taking Kofnoril-DX Syrup Sugar Free 72 hours prior to the surgery.
It is not recommended to take Kofnoril-DX Syrup Sugar Free along with any anti-depressant medication, especially MAO inhibitors (linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine), as it may lead to unpleasant side-effects or drug interaction. Also, Kofnoril-DX Syrup Sugar Free should be taken at least 14 days after the last dose of anti-depressants.
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the scheduled dose. Do not take extra medicine to make up for the missed dose.
Kofnoril-DX Syrup Sugar Free may rarely worsen the symptoms of glaucoma. Therefore, Kofnoril-DX Syrup Sugar Free should be used with caution and only when prescribed by a doctor in patients with glaucoma.
No, Kofnoril-DX Syrup Sugar Free does not contain steroids. It is a combination of three active ingredients phenylephrine, chlorpheniramine maleate, and dextromethorphan hydrobromide.
Yes, Kofnoril-DX Syrup Sugar Free can make you feel drowsy as a side effect. It contains dextromethorphan and chlorpheniramine, both of which can cause drowsiness. It's important to be cautious when performing activities that require alertness, such as driving or operating machinery, until you know how the medication affects you.
No, taking Kofnoril-DX Syrup Sugar Free in more than the recommended dose will not make it more effective. Instead, it can increase the risk of side effects. It's important to follow the dosage instructions provided by your doctor to ensure safe and effective use of the medication.
It is generally not recommended to breastfeed while taking Kofnoril-DX Syrup Sugar Free. Kofnoril-DX Syrup Sugar Free contains chlorpheniramine, an antihistamine, which can pass into the breast milk and may harm the baby. Therefore, inform your doctor that you are breastfeeding if you are advised to take this medicine.
Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack. Follow your doctor’s instructions regarding dosage and duration.
Yes Kofnoril-DX Syrup Sugar Free causes some side effects such as dry mouth, throat or nose, drowsiness, dizziness, blurred vision, headache, constipation, restlessness or excitation, and loss of appetite. If any of these side effects persist or worsen, please consult your doctor.
Yes, inform your doctor if your child has conditions like glaucoma, urinary retention, phenylketonuria (a birth defect that causes accumulation of amino acid, phenylalanine in the body), cough with mucus or cough caused by asthma, and chronic bronchitis or emphysema (a lung condition causing shortness of breath).
No, Kofnoril-DX Syrup Sugar Free interacts with other medications, including, MOIs (monoamine oxidase inhibitors), antidepressants, sedatives or tranquillizers, and alcohol. Therefore, you should inform your doctor about all the medicines, supplements, and herbal products they are currently taking before starting Kofnoril-DX Syrup Sugar Free.
Store Kofnoril-DX Syrup Sugar Free at room temperature in a cool and dry place away from sunlight. Do not freeze. Keep it out of reach of children.

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