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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Dec 13, 2024 | 11:26 AM IST
Kofkil Syrup is used to treat cough. It works by dilating and relaxing the air passages in the lungs, making breathing easier and reducing the viscosity of sputum to facilitate its removal. In some cases, this medicine may cause side effects such as nausea, diarrhoea, bloating, indigestion, vomiting, stomach upset, sweating, dizziness, headache and skin rash. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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About Kofkil Syrup

Kofkil Syrup belongs to a class of respiratory medications called 'expectorant' primarily used to treat cough. Coughing (dry or productive) is the body's way of clearing irritants (like allergens, mucus or smoke) from the airways. There are two types of coughs, namely: Dry cough and chesty cough. A dry cough is tickly and doesn't produce thick mucus, while a chesty cough (wet cough) produces mucous or sputum that helps clear the airways.

Kofkil Syrup consists of four medicines, namely: Bromohexine (mucolytic), Terbutaline (bronchodilator), Ammonium chloride (irritant/expectorant) and Menthol (cooling agent). Bromhexine makes sputum less viscous and makes it easier to cough out. Terbutaline works by dilating (expanding) and relaxing the air passages in the lungs, making breathing easier, especially in people with airway problems or respiratory obstructive disorders. Ammonium chloride is an expectorant that decreases the stickiness of mucous and helps remove it from the airways. Menthol is an organic compound that produces a cooling sensation and relieves throat irritation.

Kofkil Syrup is available in oral syrup and suspension. The most common side effects of Kofkil Syrup are nausea, diarrhoea, bloating, indigestion, vomiting, stomach upset, sweating, dizziness, headache and skin rash. Most of these side effects of Kofkil Syrup do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Let your doctor know if you have any allergic reactions to Kofkil Syrup or any other medication. Brief your medical history to the doctor if you have any heart, liver, kidney, lung diseases, depression and Parkinson's disease before taking Kofkil Syrup. Kofkil Syrup can cause sleepiness; hence avoid taking alcohol while using Kofkil Syrup. Kofkil Syrup may affect your ability to drive. It is advised not to drive whilst taking this medicine. Check with your doctor if you are pregnant, currently breastfeeding or taking any other prescribed or non-prescribed drugs. 

Uses of Kofkil Syrup

Treatment of Cough

Medicinal Benefits

Kofkil Syrup is a respiratory medication primarily used to treat cough. Kofkil Syrup consists of four medicines: Bromhexine (mucolytic), Terbutaline (bronchodilator), Ammonium chloride (irritant/expectorant) and Menthol (cooling agent). Bromhexine is a 'mucolytic agent' that makes sputum less viscous and easier to cough. Terbutaline belongs to the bronchodilators class that dilates (expands) and relaxes the air passages in the lungs, making breathing easier, especially in people with airway problems or respiratory obstructive disorders.  Ammonium chloride is an expectorant that decreases the stickiness of mucous and helps remove it from the airways. Menthol is an organic compound that produces a cooling sensation and relieves throat irritation.

Directions for Use

Your doctor will advise on how often you take Kofkil Syrup based on your medical condition. Shake the bottle well before use. Check the label for directions and take Kofkil Syrup with or without food with a measuring cup in the dose and duration prescribed by the doctor.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Kofkil Syrup

  • Nausea
  • Diarrhea
  • Bloating
  • Indigestion
  • Vomiting
  • Stomach upset
  • Sweating
  • Dizziness
  • Headache
  • Skin rash

Drug Warnings

If you are pregnant or breastfeeding, it is advised to inform your doctor before using Kofkil Syrup. If you are suffering from fits (epilepsy/seizures) or have a history of fits, please inform your doctor before taking Kofkil Syrup as it may increase the risk of recurrent fits. Kofkil Syrup is not recommended for children below 6 years of age and body weight less than 25 kg, as the safety and effectiveness were not established. If you have diabetes, regular monitoring of blood sugar levels is recommended while taking Kofkil Syrup. If you experience constipation, leg cramps, numbness or tingling, increased urination or thirst, muscle weakness or irregular heartbeats, contact your doctor, as it may be due to low potassium levels in the blood. Drink plenty of fluids while taking Kofkil Syrup to loosen mucus. If you have diabetes, fits, high blood pressure, overactive thyroid or heart problems, please inform your doctor before taking Kofkil Syrup.

Drug Interactions

Drug-Drug Interaction: Kofkil Syrup may interact with central nervous system stimulants (dextroamphetamine, amphetamine), anti-depressants (duloxetine, escitalopram, quetiapine, sertraline, isocarboxazid, selegiline, phenelzine, rasagiline, tranylcypromine), alcohol (ethanol), anti-allergic drugs (diphenhydramine), pain medicine (codeine), fits drugs (pregabalin), heart-related drugs (quinidine), anxiety treating drugs (alprazolam) and staining agents (methylene blue).

Drug-Food Interaction: Limit alcohol intake since it may worsen the side effects like dizziness and shakiness.

Drug-Disease Interaction: Brief your medical history if you have any heart, liver, or kidney diseases, stomach ulcers, inflammation of air passages, lung disorders, difficulty breathing, severe asthma, depression and Parkinson's disease before taking Kofkil Syrup.

Drug-Drug Interactions Checker List

  • DEXTROAMPHETAMINE
  • AMPHETAMINE
  • DULOXETINE
  • ESCITALOPRAM
  • QUETIAPINE
  • SERTRALINE
  • ISOCARBOXAZID
  • SELEGILINE
  • PHENELZINE
  • RASAGILINE
  • TRANYLCYPROMINE
  • ETHANOL
  • DIPHENHYDRAMINE
  • CODEINE
  • PREGABALIN
  • QUINIDINE
  • ALPRAZOLAM
  • METHYLENE BLUE

Habit Forming

No

Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Kofkil Syrup.
  • Know your triggers like allergens, such as pollen, dust and food items that make your asthma and other respiratory diseases severe.
  • Quit smoking and avoid passive smoking. Smoking also reduces the effectiveness of the medicine.
  • Drink extra fluids while you take Kofkil Syrup to help loosen congestion and lubricate the throat.
  • Eat a healthy diet and exercise regularly to strengthen your breathing muscles and boost your immune system.
  • Learning breathing exercises will help you move more air in and out of your lungs.

Special Advise

  • Regularly monitoring blood sugar levels and serum potassium levels is required while taking Kofkil Syrup.
  • ECG (electrocardiogram) of the heart is recommended, and the heartbeat should be closely monitored. 
  • Kofkil Syrup should not be given to children less than 6 years of age and weighing less than 25 kg.

Disease/Condition Glossary

Cough: It occurs as a reflex action in the throat when there is mucus or any other foreign irritant in it. Cough can be dry or productive. A productive cough (wet cough) develops sputum (phlegm or mucus) from the lungs. Cough is commonly caused as a response to allergy or viral infection but coughing up mucus is possibly an indication of infection in the respiratory tract. If you are coughing out thick, solid white mucus, it indicates that you may have a bacterial infection in the airways. Clear or light-coloured mucus indicates allergies or minor infections in the respiratory tract, and yellow or green mucus indicates a respiratory infection. 

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Alcohol

Caution

It is not known whether it is safe to consume alcohol with Kofkil Syrup. Please consult your doctor before using Kofkil Syrup. However, it is better to avoid alcohol to prevent side effects.

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Pregnancy

Caution

There is limited data on how Kofkil Syrup affects pregnancy. Kofkil Syrup may be unsafe to use during pregnancy since it may harm the developing baby. Consult your doctor before using Kofkil Syrup, if you are pregnant or planning to conceive.

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Breast Feeding

Caution

It is not known if Kofkil Syrup affects breastfeeding and passes into breast milk. Please consult your doctor before starting Kofkil Syrup.

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Driving

Caution

Do not drive or operate machinery if you experience sleepiness, dizziness, increased/uneven heart rate and shakiness while using Kofkil Syrup. This may affect your ability to drive. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Kofkil Syrup should be used with caution in patients with liver diseases. Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Kofkil Syrup.

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Kidney

Caution

Kofkil Syrup should be used with caution in patients with kidney diseases. Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Kofkil Syrup.

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Children

Caution

Kofkil Syrup is not recommended for use in children less than six years of age. The dose may have to be adjusted by your doctor, depending on the condition of your child's symptoms and age.

Country of origin

India
Other Info - KO68086

FAQs

Kofkil Syrup is used to treat cough.
Kofkil Syrup consists of four medicines: Bromhexine, Terbutaline, Ammonium chloride, and Menthol. Kofkil Syrup relieves cough symptoms by thinning the cough/mucus, making it less viscous, suppressing coughing and decreasing throat irritation by providing a soothing effect. This helps in easy coughing out of phlegm and makes breathing easier.
Yes, you may experience headaches and shakiness after using Kofkil Syrup. Drink plenty of water and take rest to manage your headache. Shakiness goes away gradually. Consult your doctor if these symptoms persist longer.
Kofkil Syrup is not recommended for use if you have a stomach ulcer since mucolytics like Bromohexine may disrupt the gastric mucosal barrier; therefore cautiously administered in patients with a stomach ulcer.
No, you are not recommended to take propranolol or other beta-blockers used to lower raised blood pressure with Kofkil Syrup as it may reduce the effectiveness of both medicines. Also, propranolol may cause a narrowing of airways sometimes, which may trigger severe asthmatic attacks or worsen breathing problems. However, you should consult a doctor before using other medicines with Kofkil Syrup.
Kofkil Syrup should be used with caution in diabetic patients if prescribed by a doctor. However, regular monitoring of blood sugar levels is recommended while taking Kofkil Syrup as it may increase blood sugar levels.
Kofkil Syrup contains terbutaline, which may decrease the potassium levels in your body, leading to hypokalemia. If you have a low potassium level, let your doctor know this before taking the Kofkil Syrup.
Kofkil Syrup can be taken either with or without food, as directed by the doctor.
Kofkil Syrup causes side effects like nausea, diarrhoea, indigestion, vomiting, stomach upset, sweating, dizziness, headache, and skin rash. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please, contact a doctor if these persist for longer durations.
Kofkil Syrup may cause dizziness, so it is best to avoid driving or operating machinery if you experience these side effects. Always, follow your doctor's advice.
Store Kofkil Syrup in a dry, and dark place. Protect from light. Keep it out of reach of children.

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