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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Keygraf 2 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

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Composition :

TACROLIMUS-2MG

Manufacturer/Marketer :

Anthem Bio Pharma

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Keygraf 2 Capsule

Keygraf 2 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Keygraf 2 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Take Keygraf 2 Capsule as prescribed. You are advised to use Keygraf 2 Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Keygraf 2 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Keygraf 2 Capsule . Avoid alcohol consumption with Keygraf 2 Capsule . Drive only if you are alert, as Keygraf 2 Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Keygraf 2 Capsule . Keygraf 2 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.

Uses of Keygraf 2 Capsule

Keygraf 2 Capsule is used for prevention of transplanted organ rejection

Directions for Use

Capsule: Take the capsule as advised by the doctor. Swallow it as a whole with water; do not crush, break or chew it.Granules: The granules should be mixed with water to make an oral suspension. Drink the prepared suspension immediately. Do not save the suspension for later use.

Medicinal Benefits

Keygraf 2 Capsule contains Tacrolimus, an immunosuppressant used to prevent organ rejection after a transplant. Keygraf 2 Capsule suppresses the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.

How Keygraf 2 Capsule Works

Keygraf 2 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that normally attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body in accepting the new organ.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Keygraf 2 Capsule

  • Nausea
  • Diarrhoea
  • Headache
  • Kidney problems
  • Infection
  • Constipation
  • Fever
  • High blood pressure

What if I have taken an overdose of Keygraf 2 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. This medicine may be harmful if swallowed. Seek emergency medical attention or call your doctor if you notice any unusual symptoms or if anyone has accidentally swallowed the medication.

Drug Warnings

Please tell your doctor if you are allergic to Tacrolimus or other medicines. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Keygraf 2 Capsule . Avoid alcohol consumption with Keygraf 2 Capsule . Drive only if you are alert, as Keygraf 2 Capsule may cause vision problems or nervous disturbances in some people. If you are about to get vaccinated, inform your doctor before taking Keygraf 2 Capsule . Keygraf 2 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system. While taking Keygraf 2 Capsule , you are advised to wear protective clothing and sunscreen while going out. You are recommended to use glass or metal materials to prepare the oral suspension. Avoid using plastic (PVC) materials to prepare the suspension, as the granules will stick to a plastic container, and your child may not receive their full dose. Do not inhale or let the granules or prepared oral suspension come in contact with your skin or eyes. In case of accidental contact with skin, wash the area well with soap and water, and if it comes in contact with the eyes, rinse with plain water.

Drug-Drug Interactions

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TacrolimusZiprasidone
Critical
TacrolimusThioridazine
Critical

Drug-Drug Interactions

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TacrolimusZiprasidone
Critical
How does the drug interact with Keygraf 2 Capsule 10's:
Taking Keygraf 2 Capsule 10's with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf 2 Capsule 10's with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
TacrolimusThioridazine
Critical
How does the drug interact with Keygraf 2 Capsule 10's:
Combining Keygraf 2 Capsule 10's with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf 2 Capsule 10's with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusMifepristone
Critical
How does the drug interact with Keygraf 2 Capsule 10's:
Taking Keygraf 2 Capsule 10's with Mifepristone may significantly increase the blood levels of Keygraf 2 Capsule 10's, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Keygraf 2 Capsule 10's with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
TacrolimusSaquinavir
Critical
How does the drug interact with Keygraf 2 Capsule 10's:
Taking Keygraf 2 Capsule 10's with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf 2 Capsule 10's with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusZiprasidone
Critical
How does the drug interact with Keygraf 2 Capsule 10's:
Taking Keygraf 2 Capsule 10's with Ziprasidone can increase the risk of irregular heart rhythm

How to manage the interaction:
Taking Keygraf 2 Capsule 10's with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusDronedarone
Critical
How does the drug interact with Keygraf 2 Capsule 10's:
Taking Keygraf 2 Capsule 10's with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf 2 Capsule 10's with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
TacrolimusCidofovir
Critical
How does the drug interact with Keygraf 2 Capsule 10's:
Taking cidofovir with Keygraf 2 Capsule 10's can increase the risk of kidney problems.

How to manage the interaction:
Taking Keygraf 2 Capsule 10's with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
TacrolimusMethotrexate
Severe
How does the drug interact with Keygraf 2 Capsule 10's:
Taking Keygraf 2 Capsule 10's with methotrexate may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Keygraf 2 Capsule 10's and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without consulting to a doctor.
TacrolimusAmikacin
Severe
How does the drug interact with Keygraf 2 Capsule 10's:
Coadministration of Keygraf 2 Capsule 10's with amikacin can increase the risk of kidney problems.

How to manage the interaction:
Although taking amikacin and Keygraf 2 Capsule 10's together can result in an interaction but can be taken if a doctor has prescribed it. Consult the doctor if you experience vomiting, irregular urination, swelling, shortness of breath, muscle cramps, weakness, or palpitation. Do not discontinue any medications without a doctor's advice.
TacrolimusEtanercept
Severe
How does the drug interact with Keygraf 2 Capsule 10's:
Taking etanercept together with Keygraf 2 Capsule 10's may increase the risk of serious infections.

How to manage the interaction:
Although taking etanercept and Keygraf 2 Capsule 10's together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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TACROLIMUS-2MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TACROLIMUS-2MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Keygraf 2 Capsule 10's treatment may lead to increased Keygraf 2 Capsule 10's levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Keygraf 2 Capsule 10's.

Diet & Lifestyle Advise

  • Include fruits and vegetables in your daily routine.
  • Follow a vitamin-C-rich diet.
  • Reduce salt intake.
  • Eat a handful of walnuts and almonds every day.
  • Reduce intake of unhealthy cholesterol and fats.
  • Consume dark chocolate with at least 70% cocoa.

Liver and Heart transplant:

  • Eat whole-grain bread, cereals and other grains, fruits and vegetables, lean meats, fish and poultry.
  • Maintain a low-fat and low-salt diet.
  • Drink low-fat milk or eat other low-fat dairy products to maintain adequate calcium.
  • Stay hydrated by drinking sufficient water and other fluids.
  • Avoid alcohol consumption.
  • Avoid grapefruit and grapefruit juice. 

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Keygraf 2 Capsule Substitute

Substitutes safety advice
  • Pangraf 2 Capsule 10's

    78.58per tablet
  • Tacrograf 2 Capsule 10's

    84.96per tablet
  • Biomus 2 mg Capsule 10's

    78.30per tablet
  • Takfa-2 Capsule 10's

    85.01per tablet
  • Tacstead 2 mg Capsule 10's

    by AYUR

    78.30per tablet
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Alcohol

Unsafe

Avoid alcohol consumption with Keygraf 2 Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Keygraf 2 Capsule .

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Pregnancy

Caution

Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Keygraf 2 Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Keygraf 2 Capsule .

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Breast Feeding

Consult your doctor

Keygraf 2 Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Keygraf 2 Capsule . You should avoid taking Keygraf 2 Capsule during breastfeeding or avoid breastfeeding while on treatment with Keygraf 2 Capsule .

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Driving

Caution

Keygraf 2 Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Keygraf 2 Capsule .

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Liver

Consult your doctor

Please consult a doctor if you have liver diseases/conditions before taking Keygraf 2 Capsule .

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Kidney

Consult your doctor

Please consult a doctor if you have Kidney diseases/conditions before taking Keygraf 2 Capsule .

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Children

Safe if prescribed

Keygraf 2 Capsule should be used in children in doses as advised by a doctor only.

FAQs

Keygraf 2 Capsule is used to prevent rejection of a transplanted organ such as a liver, kidney, or heart.
Keygraf 2 Capsule contains Tacrolimus, an immunosuppressant that works by the activity of T and B lymphocytes (cells in the immune system) that normally attacks foreign invaders and defend the body against foreign cells and infection. As a result, it helps the body accept the new organ and prevents organ rejection in patients who have had organ transplants.
Keygraf 2 Capsule may increase the risk of infections as it may weaken the immune system. Therefore, consult a doctor immediately if you have any signs of infection, such as sore throat or fever.
Keygraf 2 Capsule may increase the risk of skin cancer. Therefore, avoid or limit exposure to the sun for a long time or artificial light such as tanning beds. Wear protective clothing and use sunscreen before going out in the sun.
If you are about to receive any vaccinations, especially live vaccines such as measles, mumps, rubella (MMR), oral polio, varicella, yellow fever, intranasal influenza, BCG and TY21a typhoid vaccines, inform your doctor that you are taking Keygraf 2 Capsule because it may reduce the effectiveness of the vaccine and increase your risk of contracting the infection that the vaccine is meant to protect against.
Using Keygraf 2 Capsule with Sirolimus is not recommended in patients who have had heart or liver transplants. It is unknown if kidney transplant recipients can use it safely. Hence, please seek medical advice before combining Keygraf 2 Capsule with other medications.
Keygraf 2 Capsule may cause tremors, trembling and shaking of hands. Consult the doctor if this becomes bothersome.
Keygraf 2 Capsule is usually taken on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal.
Keygraf 2 Capsule is a macrolide antibiotic with immunosuppressant properties.
Keygraf 2 Capsule should not be taken by people who are allergic to any of its components, allergic to sirolimus or any macrolide-antibiotic, during breastfeeding, and receiving live vaccines.
Let the doctor know if you have long QT syndrome, low or high levels of potassium, low levels of calcium or magnesium, an irregular heartbeat, high blood pressure, high cholesterol levels, cystic fibrosis (an inborn disease), heart, kidney, or liver disease. Inform the doctor if you have a weak immune system or if you are due to undergo any vaccination.
Keygraf 2 Capsule decreases the activity of your immune system, increasing the risk of serious infection and cancer (lymphoma cancer). Consult the doctor if you experience symptoms of infection (sore throat, extreme tiredness, cough, flu-like symptoms, fever,) or cancer (weight loss, swollen lymph nodes in the neck, armpits, or groin, fever, excessive tiredness or weakness, night sweats, cough, chest pain, trouble breathing, or pain, swelling, or fullness in the stomach area).
No, Keygraf 2 Capsule does not have an abuse potential as it is not a controlled substance.
Side effects of Keygraf 2 Capsule include nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. If the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

No 49, Canara Bank Road, Bommasandra Industrial Area, Phase 1, Hosur Road, Bangalore 560 099, Karnataka, India.
Other Info - KEY0014

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