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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Jusvap-15 Tablet is used to treat low sodium levels and autosomal dominant polycystic kidney disease. It contains Tolvaptan which works by increasing the amount of water released from the body via urine. In some cases, this medicine may cause side effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

TOLVAPTAN-15MG

Manufacturer/Marketer :

Rene Lifescience

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Jusvap-15 Tablet

Jusvap-15 Tablet is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, Jusvap-15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
 
Jusvap-15 Tablet contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions; the increase in serum sodium concentration is solely a result of increased urine production.
 
You are advised to take Jusvap-15 Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Do not take Jusvap-15 Tablet if you are pregnant as it may cause foetal harm. Consult your doctor before taking Jusvap-15 Tablet if you are breastfeeding. Jusvap-15 Tablet is not recommended for children below 18 years as the efficacy and safety have not been established. Jusvap-15 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side effects.

Uses of Jusvap-15 Tablet

Treatment of Hyponatremia (low sodium levels) and autosomal dominant polycystic kidney disease (ADPKD).

Directions for Use

Swallow the medicine as a whole with a glass of water, and do not crush, break, or chew it.

Medicinal Benefits

Jusvap-15 Tablet belongs to a group of medicines called vasopressin V2 receptor antagonist. Jusvap-15 Tablet is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Besides this, Jusvap-15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD). Jusvap-15 Tablet works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, Jusvap-15 Tablet slows down the development of cysts in kidneys and reduces the symptoms of the disease. Jusvap-15 Tablet antagonises the effect of vasopressin; this results in an increase in free water clearance and decreases urine osmolality due to increased urinary excretion, thereby increasing serum sodium concentrations.

How Jusvap-15 Tablet Works

Jusvap-15 Tablet contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions; the increase in serum sodium concentration is solely a result of increased urine production.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Jusvap-15 Tablet

  • Dizziness
  • Headache
  • Dry mouth
  • Fatigue
  • Weakness
  • Diarrhoea
  • Thirst
  • Increased urge to urinate

What if I have taken an overdose of Jusvap-15 Tablet

Take Jusvap-15 Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include excessive urination, excessive thirst, dizziness, and faintness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Jusvap-15 Tablet if you are allergic to any of its contents, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, if you cannot tell that you are thirsty. Inform your doctor if you have liver disease, difficulty in urination, diabetes, high levels of uric acid, advanced kidney disease or if you have to restrict fluid intake due to certain medical conditions. Do not take Jusvap-15 Tablet if you are pregnant as it may cause foetal harm. Consult your doctor before taking Jusvap-15 Tablet if you are breastfeeding. Jusvap-15 Tablet is not recommended for children below 18 years as efficacy and safety have not been established. Jusvap-15 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. 

Drug-Drug Interactions

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TolvaptanAtazanavir
Critical
TolvaptanDelavirdine
Critical

Drug-Drug Interactions

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TolvaptanAtazanavir
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
When Jusvap-15 Tablet 7's and Atazanavir are taken together, may significantly increase the blood levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Atazanavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanDelavirdine
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
When Jusvap-15 Tablet 7's and Delavirdine are taken together, may significantly increase the blood levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Delavirdine, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanAmprenavir
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
Co-administration of Amprenavir with Jusvap-15 Tablet 7's can increase the risk of side effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Amprenavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanClarithromycin
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
When Jusvap-15 Tablet 7's and Clarithromycin are taken together, may significantly increase the blood levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Clarithromycin, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanTelithromycin
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
When Jusvap-15 Tablet 7's and Telithromycin are taken together, may significantly increase the blood levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Telithromycin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanNefazodone
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
When Jusvap-15 Tablet 7's and Nefazodone are taken together, may significantly increase the blood levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Nefazodone, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanPosaconazole
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
Taking Jusvap-15 Tablet 7's and Posaconazole together results in an increase in the levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
Although there is an interaction between Jusvap-15 Tablet 7's and Posaconazole, it can be taken if prescribed by a doctor. However, consult a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures (fits). Do not stop using any medications without a doctor's advice.
TolvaptanBoceprevir
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
Co-administration of Boceprevir and Jusvap-15 Tablet 7's may significantly increase the blood levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Boceprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanTelaprevir
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
When Jusvap-15 Tablet 7's and Telaprevir are taken together, may significantly increase the blood levels and effects of Jusvap-15 Tablet 7's.

How to manage the interaction:
There may be a possibility of interaction between Jusvap-15 Tablet 7's and Telaprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanMifepristone
Critical
How does the drug interact with Jusvap-15 Tablet 7's:
When Jusvap-15 Tablet 7's is taken with Mifepristone, it may increase the levels of Jusvap-15 Tablet 7's, which may increase the risk of side effects.

How to manage the interaction:
Taking Jusvap-15 Tablet 7's and Mifepristone together is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOLVAPTAN-15MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOLVAPTAN-15MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit

How to manage the interaction:
Consuming grapefruit juice while taking Jusvap-15 Tablet 7's can increase the effects of Jusvap-15 Tablet 7's. Avoid taking Jusvap-15 Tablet 7's with grapefruit juice.

Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Manage stress with meditation, yoga, and massage.
  • Drink plenty of fluids.
  • Rehydration beverages that contain electrolytes are also helpful.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

Jusvap-15 Tablet Substitute

Substitutes safety advice
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  • Hyponat-O 15 Tablet 10's

    67.28per tablet
  • Vaptan Tablet 10's

    by AYUR

    90.00per tablet
  • Resodim 15 Tablet 4's

    180.68per tablet
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Alcohol

Unsafe

Avoid consuming alcohol while taking Jusvap-15 Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Jusvap-15 Tablet belongs to pregnancy category C. Jusvap-15 Tablet is not recommended for use in pregnant women as it may cause foetal harm. Women of childbearing age must use effective contraception while taking Jusvap-15 Tablet.

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Breast Feeding

Unsafe

Jusvap-15 Tablet is not recommended for use in breastfeeding women. Consult your doctor if you are breastfeeding; your doctor will decide whether Jusvap-15 Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Jusvap-15 Tablet may cause dizziness, weakness and tiredness. Do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Jusvap-15 Tablet should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Jusvap-15 Tablet should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Unsafe

Jusvap-15 Tablet is not recommended for children below 18 years as efficacy and safety have not been established.

FAQs

Jusvap-15 Tablet is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, Jusvap-15 Tablet is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
Jusvap-15 Tablet works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, Jusvap-15 Tablet slows down the development of cysts in the kidneys, reduces the symptoms of the disease, and increases urine production. Thereby increases serum sodium concentrations.
Dry mouth could be a side-effect of Jusvap-15 Tablet. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Diarrhoea could be a side-effect of Jusvap-15 Tablet. Drink plenty of fluid to prevent dehydration if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or if you find blood in stools.
Jusvap-15 Tablet may cause the liver to not work properly. Consult your doctor immediately if you experience nausea, vomiting, fever, loss of appetite, abdominal pain, tiredness, dark urine, jaundice, itching and flu-like symptoms.
Jusvap-15 Tablet may cause water loss due to increased urine production. This might result in side-effects such as thirst, dry mouth and kidney problems. To prevent this, drink plenty of water regularly. Drink 1-2 glasses of water before going to bed even though you are not thirsty. Special care must be taken in patients with diseases that might reduce fluid intake.
Consult your doctor before taking Jusvap-15 Tablet if you are diabetic as Jusvap-15 Tablet might increase the blood sugar levels. Regular monitoring of blood glucose levels while taking Jusvap-15 Tablet is advised.
You are advised to take Jusvap-15 Tablet for the duration prescribed by the doctor. Jusvap-15 Tablet should not be taken for more than 30 days.
Jusvap-15 Tablet might increase the blood sugar levels. Consult the doctor if you are diabetic.
Do not take Jusvap-15 Tablet if you are allergic to any of its components, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, or if you cannot tell that you are thirsty.
Avoid consuming grapefruit or its juice while taking Jusvap-15 Tablet as it might increase the effects of the medicine in the body.
Do not exceed the prescribed dose as it might cause an overdose. Taking an excess of Jusvap-15 Tablet may cause excessive thirst, dizziness, excessive urination, or fainting. Consult the doctor if you experience these symptoms.
Jusvap-15 Tablet is not recommended for patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney problems.
If you miss a dose of Jusvap-15 Tablet take it as soon as you remember, However, if it is almost time for the scheduled dose, skip the missed dose and take the next dose at the scheduled time.
Jusvap-15 Tablet is not recommended for use during pregnancy and breastfeeding.
Common side effects are dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Talk to your doctor if you experience these side effects persistently.
Store Jusvap-15 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Treatment with Jusvap-15 Tablet should be started and re-started in a hospital or in the presence of a healthcare professional to monitor the sodium levels in your blood closely. Too rapid correction of hyponatremia (low sodium levels) may cause osmotic demyelination syndrome (serious nerve damage). Consult the doctor if you notice symptoms of osmotic demyelination syndrome such as difficulty speaking, feeling that food or drinks are getting stuck in your throat, difficulty swallowing, mood changes, drowsiness, confusion, body movements that are difficult to control, weakness of the arms or legs, or seizures.

Country of origin

India

Manufacturer/Marketer address

A-206, Dimple Arcade, Asha Nagar, Near Om Sweets, Kandivali (E), Mumbai-400101
Other Info - JUS0061

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