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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:38 PM IST
Justoza M 5/1000 Tablet is used to treat type 2 diabetes mellitus. It contains Metformin and Dapagliflozin which work by eliminating excess sugars from the body through urine and restoring the body’s response to insulin. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, headache, and dizziness. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer

Mankind Pharma Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Justoza M 5/1000 Tablet

Justoza M 5/1000 Tablet belongs to the class of 'antidiabetic drugs', primarily used to treat type 2 diabetes mellitus with a proper diet and exercise. Justoza M 5/1000 Tablet also lowers the risk of heart failure in type 2 diabetic patients with heart diseases. Diabetes mellitus is a metabolic disease that causes high blood sugar levels. It occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produce little or no insulin at all. Justoza M 5/1000 Tablet is not indicated for use in type 1 diabetes.

Justoza M 5/1000 Tablet is composed of two antidiabetic medicines, namely: Metformin and Dapagliflozin. Metformin belongs to the class of biguanides and manages blood sugar levels, particularly in obese patients. It exhibits a nonpancreatic effect to reduce blood glucose levels without increasing insulin secretion. Dapagliflozin belongs to the class of gliflozins. It works by reducing blood sugar levels by eliminating excess sugars from the body through urine.

Take Justoza M 5/1000 Tablet as advised by your doctor. Some common side effects of Justoza M 5/1000 Tablet include nausea, vomiting, diarrhoea, headache, weakness, runny nose, genital infection, dizziness, taste changes, and sore throat. Sometimes, Justoza M 5/1000 Tablet can cause side effects like lactic acidosis (a rare, but serious metabolic complication of excess lactic acid in the blood that is caused by metformin accumulation) and diabetic ketoacidosis (excess production of blood acids (ketones)). These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor. 

Justoza M 5/1000 Tablet may cause hypoglycaemia (low blood sugar); hence it advised to take healthy food with enough calories and avoid heavy exercises. Do not take or stop this medicine, if the doctor did not advise you to do so. Before starting Justoza M 5/1000 Tablet , let your doctor know if you have any medical history of heart, kidney or liver diseases, breathing problems, blood disorders, dehydration, alcohol use, low blood pressure, and yeast infection of genitals. It is advised to avoid your alcohol intake while using Justoza M 5/1000 Tablet to decrease the risk of lactic acidosis. Justoza M 5/1000 Tablet is not recommended for use during the second or third trimester of pregnancy and breastfeeding.

Uses of Justoza M 5/1000 Tablet

Treatment of Type 2 Diabetes mellitus.

Medicinal Benefits

Justoza M 5/1000 Tablet treats type 2 diabetes mellitus and contains Metformin and Dapagliflozin. Metformin is a biguanide and manages blood sugar levels, particularly in obese patients. It exhibits a nonpancreatic effect to reduce blood glucose levels without increasing insulin secretion. It is also known as an insulin sensitizer as it increases the effects of insulin. Metformin is considered a unique antidiabetic drug since it does not cause hypoglycemia (lowered blood sugar levels). Dapagliflozin belongs to the class of gliflozins. It works by reducing blood sugar levels by eliminating excess sugars from the body through urine. Justoza M 5/1000 Tablet also reduces the risk of heart failure in patients with type 2 diabetes and heart disease. Justoza M 5/1000 Tablet may be advised with or without other medications along with diet and exercise to control blood sugar levels. 

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it. Take it preferably with a meal since it lowers blood sugar levels and may cause gastrointestinal side effects. Your doctor may start the course with a low dose and gradually maintain an effective dose to achieve the required blood glucose control.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Justoza M 5/1000 Tablet

  • Nausea

  • Vomiting
  • Diarrhoea
  • Headache
  • Weakness
  • Runny nose
  • Genital infection
  • Dizziness
  • Taste changes
  • Sore throat
  • Lactic acidosis (build-up of lactic acid in the bloodstream) (rare)
  • Diabetic ketoacidosis (a diabetic complication with excess blood acids) (rare)

Drug Warnings

Inform your doctor if you take other antidiabetic drugs so that the dosage of Justoza M 5/1000 Tablet will be adjusted accordingly. Do not abruptly stop taking Justoza M 5/1000 Tablet midway if the doctor did not advise you. Justoza M 5/1000 Tablet may cause hypoglycaemia (low blood sugar); hence it is advised to make healthy food with enough calories and avoid heavy exercises. Brief your medical history to doctor if you have any heart, kidney or liver diseases, breathing problems (asthma, obstructive lung diseases), blood problems like anaemia (lack of blood cells), vitamin B12 deficiency, pancreas problems/surgery, dehydration, alcohol use, low blood pressure, and yeast infection of genitals before taking Justoza M 5/1000 Tablet . Avoid alcohol intake while using Justoza M 5/1000 Tablet since it may increase the risk of lactic acidosis. Justoza M 5/1000 Tablet is not recommended for use during the second or third trimester of pregnancy and breastfeeding. Your doctor may advise alternate medications to control your diabetic condition in such cases. Justoza M 5/1000 Tablet is not recommended for people younger than 18 years of age.

Drug Interactions

Drug-Drug Interaction: Justoza M 5/1000 Tablet may interact with water pills (hydrochlorothiazide), pain killers (ibuprofen, celecoxib), drugs that treat acidity (cimetidine), asthma medicines, blood pressure-lowering drugs, and corticosteroids.

Drug-Food Interaction: Avoid alcohol intake since it increases the risk of lactic acidosis.

Drug-Disease Interaction: Tell your doctor before taking Justoza M 5/1000 Tablet if you have any heart, kidney or liver diseases, breathing problems, blood disorders, dehydration, alcohol use, low blood pressure, and yeast infection of genitals. Justoza M 5/1000 Tablet is contraindicated in patients with severe renal impairment and metabolic acidosis/diabetic ketoacidosis.

Drug-Drug Interactions Checker List

  • HYDROCHLOROTHIAZIDE
  • IBUPROFEN
  • CELECOXIB
  • CIMETIDINE

Habit Forming

No

Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Justoza M 5/1000 Tablet for more than once per day. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Justoza M 5/1000 Tablet .

  • Maintain a fibre-rich diet and include healthy carbohydrates from fruits, vegetables and whole grains to maintain your blood glucose levels.

  • Eat at regular intervals.

  • Keep a check on your weight and exercise regularly to keep your heart healthy.

  • Your doctor also guides you on noticing and managing the early symptoms of high/low blood sugar levels.

  • Gastrointestinal side effects can be managed with simple modifications in your lifestyle. These include cutting down on sugars and fatty foods, avoiding carbonated drinks and foods that cause gas. 

Special Advise

  • It is advised to monitor your blood sugar levels regularly.

  • If you need to undergo any x-ray or CT scan using a dye that should be injected into your veins, your doctor may suggest you stop taking Justoza M 5/1000 Tablet temporarily.

  • Regular monitoring of kidney functioning is advised while using Justoza M 5/1000 Tablet .

  • Justoza M 5/1000 Tablet may make you test positive for a urine glucose test, hence inform your doctor in advance that you take Justoza M 5/1000 Tablet . 

Disease/Condition Glossary

Diabetes mellitus, also known as adult-onset diabetes, is a metabolic disease that causes high blood sugar levels. It is type 2 diabetes and occurs when the insulin (a hormone produced by the beta cells of the pancreas) is resistant in breaking the glucose to produce energy (insulin resistance) or the pancreas (an organ behind the stomach) produces little or no insulin at all. This disease mostly occurs in people aged above 40 years, but can also occur in childhood based on the risk factors. The treatment includes oral glucose-lowering medicines and insulin shots. 

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Alcohol

Unsafe

It is advised to avoid alcohol intake since it may worsen the side effects like lactic acidosis and increase the risk of developing low blood sugar levels.

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Pregnancy

Unsafe

Dapagliflozin in Justoza M 5/1000 Tablet is not recommended during the second or third trimester of pregnancy. Your doctor may suggest other medications to control your blood sugar levels. Please consult your doctor before starting Justoza M 5/1000 Tablet if you are pregnant or planning to conceive.

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Breast Feeding

Unsafe

Justoza M 5/1000 Tablet may be unsafe to use during breastfeeding since it is excreted into the breast milk. Please seek medical advice for further information.

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Driving

Unsafe

Your driving may be affected if your blood sugar levels are too high or too low. Do not drive or operate machinery if you also experience blurred vision, dizziness or drowsiness due to extremely low or high blood sugar.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment when prescribed Justoza M 5/1000 Tablet .

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Kidney

Unsafe

Justoza M 5/1000 Tablet is contraindicated in patients with severe renal impairment/kidney diseases. Let your doctor know if you have any history of kidney diseases when you are prescribed Justoza M 5/1000 Tablet .

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Children

Unsafe

Justoza M 5/1000 Tablet is not recommended for people younger than 18 years of age.

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase 3, New Delhi - 110020.
Other Info - JUS0070

Author Details

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FAQs

Justoza M 5/1000 Tablet belongs to the class of 'antidiabetic drugs', primarily used to treat type 2 diabetes mellitus with a proper diet and exercise. Justoza M 5/1000 Tablet also lowers the risk of heart failure in type 2 diabetic patients with heart diseases.
Justoza M 5/1000 Tablet contains two antidiabetic medicines: Metformin and Dapagliflozin. These drugs lower the blood sugar levels in type 2 diabetes mellitus by eliminating excess sugars through urine and also by increasing the activity of insulin.
Justoza M 5/1000 Tablet may cause low blood sugar levels (hypoglycaemia) and can make you hungry, dizzy, irritable, confused, anxious, or shaky. Hence, it is advised to take Justoza M 5/1000 Tablet with a meal. To immediately treat hypoglycaemia, it is advised to eat or drink fast-acting sugar sources like fruit juices, hard candy, raisins or non-diet soda.
Your doctor may advise Justoza M 5/1000 Tablet with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve the controlled blood sugar levels while using Justoza M 5/1000 Tablet with or without other antidiabetic drugs.
Justoza M 5/1000 Tablet should be used with caution in heart, kidney or liver diseases, breathing problems (asthma, obstructive lung disease), blood disorders (anaemia, vitamin B12 deficiency), dehydration, alcohol use, low blood pressure, pancreas problems/surgery, and yeast infection of genitals. Justoza M 5/1000 Tablet is contraindicated in patients with severe renal impairment and metabolic acidosis/diabetic ketoacidosis.
While using Justoza M 5/1000 Tablet , if you experience vomiting, stomach/abdominal pain, muscle cramps, sick feeling, severe tiredness, difficulty in breathing, or reduced body temperature and heartbeat, it is important to seek immediate medical help since these are the symptoms of lactic acidosis. Lactic acidosis is a rare but serious complication caused due to accumulation of metformin. It is a medical emergency and needs immediate treatment. Please consult your doctor for further information.
It is not recommended to use Justoza M 5/1000 Tablet along with water pills/diuretics. Simultaneous use of Justoza M 5/1000 Tablet and water pills causes dehydration and may increase the risk of lactic acidosis.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double the dose.
The side effects of Justoza M 5/1000 Tablet include headache, nausea, vomiting, diarrhoea, runny or stuffy nose, sore throat and genital infections. If these side effects persist or worsen, please consult your doctor.
You are recommended to consult your doctor before taking Justoza M 5/1000 Tablet with insulin as it may increase the risk of hypoglycemia (low blood sugar). You may need a dose adjustment or regular monitoring of blood sugar to use these medicines safely.
No, avoid taking Justoza M 5/1000 Tablet if you have any kidney problems, as it works by excreting excess sugar through urine.
No, usually Justoza M 5/1000 Tablet does not cause loss of body weight. On the other hand, rapid loss of body weight is a sign of a Diabetic ketoacidosis, a serious medical condition.
No, Justoza M 5/1000 Tablet is only useful in type 2 diabetes mellitus, in which the body either produces less amount of insulin or cannot utilise it.

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