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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 22, 2024 | 7:36 PM IST
Jolavi Tablet is used to treat orthostatic hypotension (sudden lowering in blood pressure on standing). It contains midodrine, which works by tightening the blood vessels, thereby increasing blood pressure. In some cases, this medicine may cause side effects such as headache, nausea, heartburn, and pain during urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Synonym

MIDODRINE HYDROCHLORIDE

Composition

MIDODRINE-2.5MG

Manufacturer/Marketer

Jolly Healthcare

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Jolavi Tablet

Jolavi Tablet belongs to a category of medications called ‘Antihypotensives’ primarily used to treat hypotension (low blood pressure). Hypotension is when blood pressure drops below the normal range, reducing cardiac output and hypovolemia (low blood volume). It can cause dizziness, weakness, fainting, and risk of injury from falls.

Jolavi Tablet contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.

Take Jolavi Tablet as prescribed by your doctor. Depending on your medical condition, you are advised to take Jolavi Tablet for as long as your doctor prescribes it. Some people may experience Supine hypertension, Reflex bradycardia, Arrhythmias, Rash, Nausea, Vomiting, Dyspepsia, Headache, and Urinary retention. Most of these side effects of Jolavi Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to Jolavi Tablet or other medicines. If you are a pregnant woman or nursing mother, do not consume Jolavi Tablet without first consulting your doctor. It should not be used in children below 18 years. Midodrine is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.

Uses of Jolavi Tablet

Treatment of Idiopathic postural hypotension or hypotension.

Medicinal Benefits

Jolavi Tablet contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Jolavi Tablet

  • Supine hypertension

  • Chest pain

  • Palpitations

  • Headache

  • Blurred vision

  • Reflex bradycardia

  • Arrhythmias

  • Rash

  • Nausea

  • Vomiting

  • Dyspepsia

  • Urinary retention

Drug Warnings

If you are known to be allergic to Jolavi Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. If you get pregnant during treatment with Midodrine, you must stop the treatment immediately once the pregnancy is confirmed. It should not be used in children below 18 years. Midodrine is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.

Drug Interactions

Drug-drug interactions: Jolavi Tablet may interact with drugs used to treat depression and anxiety (e.g. duloxetine), medicines used to help control the amount of sodium and fluids in your body (e.g. fludrocortisone), and medications used to treat high blood pressure (e.g. metoprolol).

Drug-food interactions: Consuming alcohol with Jolavi Tablet is not advisable as it may cause unpleasant side effects.

Drug-disease interactions: Jolavi Tablet should be used with caution in patients with heart disease/ hypertensive effects, kidney or liver dysfunction and diabetes.

Drug-Drug Interactions Checker List

  • DULOXETINE
  • FLUDROCORTISONE
  • METOPROLOL

Habit Forming

No

Diet & Lifestyle Advise

  • Add foods with high vitamin B12, including eggs, fortified cereals, and nutritional yeast, to your daily diet.

  • Salty foods can increase blood pressure. Try eating canned soup, cottage cheese, olives, and pickled items.
  • Drink coffee and caffeinated tea, which may increase blood pressure by stimulating the cardiovascular system.
  • Eat small meals more frequently; large meals may drop in blood pressure as your body works harder to digest larger meals.
  • Drink more water and limit alcohol; dehydration lowers blood pressure.
  • Change body position by standing up slowly.
  • Avoid prolonged bed rest.
  • If you exercise outdoors in extreme heat, take frequent breaks.
  • Avoid spending a long time in saunas, hot tubs, and steam rooms which cause dehydration.

Disease/Condition Glossary

Hypotension: Low blood pressure is when blood pressure drops below the normal range. It can cause dizziness, weakness, fainting, and risk of injury from falls. Also, severely low blood pressure can deprive your body of enough oxygen to carry out its functions, damaging your heart and brain. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure in arteries when the heart rests between heartbeats. Ideal blood pressure should be 120/80 mmHg. Hypotension exists when the systolic pressure is less than 90 mmHg and the diastolic pressure is less than 60 mmHg.

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Alcohol

Caution

Consuming alcohol along with Jolavi Tablet is not advisable as it may cause unpleasant side effects.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor, and there is no substantial research yet on the use of Jolavi Tablet in breastfeeding/nursing mothers.

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Driving

Caution

Patients who experience dizziness or lightheadedness while receiving Midodrine should refrain from operating machinery.

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Liver

Caution

Limited information is available on the use of Jolavi Tablet in patients with liver disease. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

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Kidney

Caution

Limited information is available on the use of Jolavi Tablet in patients with Kidney disease. Your doctor will weigh the benefits and potential risks before prescribing them. Please consult your doctor.

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Children

Unsafe

Jolavi Tablet is not recommended for children below 18 years of age.

Country of origin

India
Other Info - JOLA227

Author Details

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FAQs

Jolavi Tablet is used to treat idiopathic postural hypotension or hypotension (low blood pressure)
Jolavi Tablet contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.
Do not stop taking Jolavi Tablet on your own. Depending on your medical condition, you are advised to take Jolavi Tablet for as long as your doctor has prescribed it for you. Do not hesitate to speak with your doctor if you experience difficulty while taking Jolavi Tablet.
Jolavi Tablet is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.
Jolavi Tablet is metabolised to desglymidodrine, an active metabolite that activates alpha-1-adrenergic receptors on arterioles and venules, causing smooth muscle contraction and blood pressure increase. Midodrine may cause a drop in heart rate due to the vagal reflex.
The side effects of Jolavi Tablet include nausea, vomiting, indigestion, supine hypertension (high blood pressure while lying down), and dysuria (painful or uncomfortable urination). If these side effects persist or worsen, please consult your doctor.
Yes, Jolavi Tablet may cause high blood pressure when you are lying flat on your back (supine hypertension). Jolavi Tablet should only be used by people whose low blood pressure affects their daily activities and in people who could not be treated successfully with other therapies.
You are advised not to lie down immediately after taking Jolavi Tablet due to the risk of supine hypertension (high blood pressure when you are lying flat on your back). Therefore, it is recommended to take the final dose of the day at least 4 hours before bedtime. By elevating the head, you can reduce the risk of supine hypertension during the night.
Jolavi Tablet may take about 1 hour to show its effects. Though the effect lasts for about 2-3 hours, the action lasts for a short time only.
Take Jolavi Tablet exactly as advised by your doctor. It is taken orally with or without food. Swallow it as a whole with a glass of water. Do not break, crush or chew it.
Jolavi Tablet is not recommended for patients who are allergic to any of its components, who have unusually slow heart rate, severe heart disease, high blood pressure, conditions causing tightening of the arteries, urinary retention (when the bladder cannot empty properly), overactive thyroid, enlarged prostate gland, pheochromocytoma (tumour of the adrenal medulla), acute or severe kidney disease, poor vision as a result of diabetes and narrow-angle glaucoma (elevated pressure in the eye).
Before starting Jolavi Tablet, you may need to get your liver and kidney function tests done and check your blood pressure. After starting the treatment, keep a constant track of your heart rate and blood pressure, especially after lying down.
Symptoms of supine hypertension include shortness of breath, chest pain, palpitations (abnormalities of heartbeat), blurred vision, and headache. If you develop these symptoms, consult your doctor immediately. The doctor may lower the dose of Jolavi Tablet or discontinue treatment if the symptoms persists.
You should be cautious while using Jolavi Tablet and metoprolol together as it can decrease your heart rate significantly. If you experience dizziness, fainting and slow pulse, inform your doctor as the dose of these medicines may need to be adjusted. However, please consult your doctor before using other medicines with Jolavi Tablet.

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