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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Itralase 100 Capsule is an antifungal medicine used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. It contains Itraconazole, which works by killing fungi. Some people may experience side effects such as nausea, headache, diarrhoea, tiredness, cough, cold, throat pain, back pain and stomach pain. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ITRACONAZOLE-100MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Itralase 100 Capsule

Itralase 100 Capsule is an antifungal medicine used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. Fungal infection is a disease in which a fungus attacks the tissue and causes infection. Fungal infections may be contagious (spread from one person to another).

Itralase 100 Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, it causes the main components of fungal cells to leak out, kill fungi, and clear the fungal infection.

Take Itralase 100 Capsule as prescribed. Your doctor will advise you on how often you take Itralase 100 Capsule based on your medical condition. Some people may experience nausea, headache, diarrhoea, tiredness, cough, cold, throat pain, back pain and stomach pain. Most of these side effects of Itralase 100 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Itralase 100 Capsule or any other medicines, please tell your doctor. Itralase 100 Capsule is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy or a nursing mother, it is advised to consult a doctor before using Itralase 100 Capsule . Do not take Itralase 100 Capsule if you have or have heart failure, as it may cause severe life-threatening adverse effects. If you have kidney, liver, heart or lung problems, inform your doctor before taking Itralase 100 Capsule . Avoid taking fentanyl (a strong opioid narcotic medicine) with Itralase 100 Capsule as it may cause severe breathing problems and can even lead to death. If you experience numbness or tingling in your hands or feet, stop taking Itralase 100 Capsule and consult your doctor immediately as they might be symptoms of nerve damage.

Uses of Itralase 100 Capsule

Treatment of Fungal infections

Directions for Use

Tablet: Take it with food to avoid stomach upset or as advised by the doctor. Swallow the whole tablet with a glass of water. Do not break, crush or chew it. If you are taking any stomach acid suppressor or have achlorhydria (stomach does not produce hydrochloric acid), take Itralase 100 Capsule with cola.

Medicinal Benefits

Itralase 100 Capsule is an antifungal used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Itralase 100 Capsule inhibits the production of ergosterol (a main component of cell membranes of fungi). Thereby weakening and damaging the fungal cell membranes, causing the main components of fungal cells to leak out. Thus, it kills fungi and clears the fungal infection.

How Itralase 100 Capsule Works

Itralase 100 Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, it causes the main components of fungal cells to leak out, kill fungi, and clear the fungal infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Itralase 100 Capsule

  • Nausea
  • Headache
  • Diarrhoea
  • Tiredness
  • Cough
  • Cold
  • Throat pain
  • Back pain
  • Stomach pain

What if I have taken an overdose of Itralase 100 Capsule

Do not take more than the prescribed dose of Itralase 100 Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

If you are known to be allergic to Itralase 100 Capsule or any other medicines, please tell your doctor. Itralase 100 Capsule is a pregnancy category C drug and may cause harm to the unborn baby. However, if you are pregnant, planning for pregnancy, or are a nursing mother, it is advised to consult a doctor before using Itralase 100 Capsule . Avoid taking fentanyl (a strong opioid pain killer narcotic medicine) with Itralase 100 Capsule , as it may cause severe breathing problems and can even lead to death. Do not take Itralase 100 Capsule if you had heart failure as it may cause severe life-threatening adverse effects. If you experience a yellow colour change of your eyes or skin, dark coloured urine, stomach pain, pale stools, loss of appetite, unusual tiredness, vomiting or nausea, stop taking Itralase 100 Capsule and consult a doctor immediately as they might be symptoms of liver failure. If you have kidney, liver, heart, or lung problems, inform your doctor before taking Itralase 100 Capsule .

Drug-Drug Interactions

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ItraconazoleColchicine
Critical
ItraconazoleTriazolam
Critical

Drug-Drug Interactions

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ItraconazoleColchicine
Critical
How does the drug interact with Itralase 100 Capsule:
Coadministration of colchicine with Itralase 100 Capsule may increase the blood levels of colchicine, increasing the risk of serious side effects.

How to manage the interaction:
Colchicine with Itralase 100 Capsule can be taken if prescribed by a doctor, despite the possibility of an interaction. However, contact a doctor if you experience abdominal pain, nausea, vomiting, diarrhea, fever, muscle pain, weakness, fatigue, and/or numbness or tingling in your hands and feet. Do not stop using any medications without first talking to your doctor.
ItraconazoleTriazolam
Critical
How does the drug interact with Itralase 100 Capsule:
Co-administration of Triazolam and Itralase 100 Capsule may significantly increase the levels of Triazolam.

How to manage the interaction:
Although combining Triazolam and Itralase 100 Capsule may possibly lead to an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you get extremely drowsy and your breathing becomes slow. Without consulting a doctor, never stop taking any medication.
ItraconazoleEplerenone
Critical
How does the drug interact with Itralase 100 Capsule:
The blood levels and effects of eplerenone may be greatly increased when combined with Itralase 100 Capsule.

How to manage the interaction:
Although there is a possible interaction between Eplerenone and Itralase 100 Capsule, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
ItraconazoleNisoldipine
Critical
How does the drug interact with Itralase 100 Capsule:
The blood levels and effects of nisoldipine may be greatly increased when used with Itralase 100 Capsule.

How to manage the interaction:
Nisoldipine and Itralase 100 Capsule may interact, but if prescribed by a doctor, they can be used together. Consult a physician if you have symptoms that include an irregular heartbeat, accumulation of fluid in legs or hands, or abnormally low blood pressure. Without consulting a doctor, never stop taking any medication.
ItraconazoleSilodosin
Critical
How does the drug interact with Itralase 100 Capsule:
Coadministration of Itralase 100 Capsule with Silodosin can increase the blood levels and effects of Silodosin, which may lead to side effects including extremely low blood pressure and increased heart rate.

How to manage the interaction:
Taking Itralase 100 Capsule with Silodosin together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
ItraconazoleIsavuconazole
Critical
How does the drug interact with Itralase 100 Capsule:
The blood levels and effects of Isavuconazole may be significantly enhanced by taking Itralase 100 Capsule along with it.

How to manage the interaction:
Co-administration of Isavuconazole and Itralase 100 Capsule can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
ItraconazoleAlprazolam
Critical
How does the drug interact with Itralase 100 Capsule:
Alprazolam's blood levels may be significantly raised when combined with Itralase 100 Capsule.

How to manage the interaction:
Although combining Alprazolam and Itralase 100 Capsule may lead to an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you get extremely drowsy and your breathing becomes slow. Without consulting a doctor, never stop taking any medication.
ItraconazoleSimvastatin
Critical
How does the drug interact with Itralase 100 Capsule:
Simvastatin's blood levels and effects may be greatly increased when combined with Itralase 100 Capsule.

How to manage the interaction:
Simvastatin and Itralase 100 Capsule may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you have side effects such unexplained pain in the muscles or tenderness, muscle weakness, fever or flu-like symptoms, or dark urine. Without consulting a doctor, never stop taking any medication.
ItraconazoleCisapride
Critical
How does the drug interact with Itralase 100 Capsule:
The blood level of Cisapride may be significantly raised by combining Cisapride with Itralase 100 Capsule.

How to manage the interaction:
Despite the possibility of an interaction when cisapride and Itralase 100 Capsule are combined, they can be taken if a doctor prescribes them. Consult a doctor if you develop any side symptoms, such as fainting, lightheadedness, dizziness, or rapid or pounding heartbeats. Without consulting a doctor, never stop taking any medication. Note: Cisapride is no longer available in the market.
ItraconazoleTolvaptan
Critical
How does the drug interact with Itralase 100 Capsule:
Co-administration of Tolvaptan and Itralase 100 Capsule may significantly raise Tolvaptan blood levels and effects.

How to manage the interaction:
There may be a possibility of interaction between Tolvaptan and Itralase 100 Capsule, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ITRACONAZOLE-100MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ITRACONAZOLE-100MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming Grapefruit, Grapefruit juice with Itralase 100 Capsule may impair the absorption of Itralase 100 Capsule, resulting in decreased antifungal effects. Avoid consuming Grapefruit and grapefruit juice with Itralase 100 Capsule.

Diet & Lifestyle Advise

  • Regularly change your socks and wash your feet. Avoid shoes that make your feet sweaty and hot.
  • In wet places such as changing rooms and gym showers, don’t walk on barefoot to prevent fungal infections.
  • Do not scratch the affected area of skin as it can spread the infection to other body parts.
  • Avoid sharing towels, combs, bedsheets, shoes or socks with others.
  • Wash your bed sheets and towels regularly.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Itralase 100 Capsule Substitute

Substitutes safety advice
  • Canditral 100 Capsule 10's

    by Others

    14.09per tablet
  • Syntran 100 Capsule 10's

    by Others

    14.09per tablet
  • Itaspor Capsule 10's

    by Others

    15.53per tablet
  • Alcros 100 Capsule 10's

    by AYUR

    16.74per tablet
  • Itratuf Capsule 15's

    by AYUR

    13.95per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Itralase 100 Capsule as it may increase the risk of liver problems and other adverse effects.

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Pregnancy

Unsafe

Itralase 100 Capsule is category C pregnancy drug and is unsafe for pregnant women as it may cause harm to the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Itralase 100 Capsule .

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Breast Feeding

Caution

Itralase 100 Capsule is excreted in human milk and may harm the baby. Therefore, Itralase 100 Capsule is given to breastfeeding mothers only if doctor thinks benefits are greater than risks.

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Driving

Caution

Itralase 100 Capsule may cause dizziness, hearing loss, double or blurred vision in some people. Therefore, drive only if you alert after taking Itralase 100 Capsule .

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Liver

Caution

Take Itralase 100 Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Itralase 100 Capsule with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Itralase 100 Capsule is not recommended for children below 12 years as the safety and effectiveness were not established.

FAQs

Itralase 100 Capsule is used to treat fungal infections of the mouth, throat, toenails, fingernails or lungs. It works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby killing fungi and clearing the fungal infection.
You are not recommended to take Itralase 100 Capsule with simvastatin as co-administration of these two medicines may cause muscle weakness, unexplained muscle pain or tenderness, dark coloured urine, fever or flu symptoms. However, please consult a doctor before using Itralase 100 Capsule with other medicines.
No, Itralase 100 Capsule is not recommended for use during pregnancy as it may cause harm to the fetus. Also, it is advised to use effective contraceptive measures while taking Itralase 100 Capsule and after 2 months of stopping treatment with Itralase 100 Capsule . However, please inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before taking Itralase 100 Capsule .
Itralase 100 Capsule may cause temporary or permanent hearing loss in some people. It is not necessary for everyone taking Itralase 100 Capsule to experience this adverse effect. However, if you notice any changes in hearing, stop taking Itralase 100 Capsule and consult a doctor immediately.
You are advised to take antacids (drugs used to reduce acid in the stomach) such as omeprazole, pantoprazole and esomeprazole at least 1 hour before or 2 hours after taking Itralase 100 Capsule as co-administration of these medicines at the same time may reduce the effectiveness of Itralase 100 Capsule because antacids decrease the absorption and blood levels of Itralase 100 Capsule . However, please consult a doctor before taking other medicines with Itralase 100 Capsule .
Yes, fungal infection is a contagious skin condition which spreads from one person to another through direct skin to skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.
You are not recommended to stop taking Itralase 100 Capsule without consulting your doctor as it may cause recurring infection. Therefore, take Itralase 100 Capsule for as long as your doctor has prescribed it, and if you experience any difficulty while taking Itralase 100 Capsule , please consult your doctor.
Inform your doctor if you are sexually active and discuss effective contraception methods. Itralase 100 Capsule may reduce the effectiveness of oral contraceptive pills. Thus, you are advised to use barrier methods of contraception like condoms, if you are taking Itralase 100 Capsule .
Inform the doctor about your detailed medical and surgical history, if you have liver, kidney or heart disease or fits and if you are pregnant, breastfeeding or planning pregnancy. Inform your doctor if you are taking any other medicines including supplements or herbal products as Itralase 100 Capsule may interact with other medicines. Also, let your doctor know if you are stopping any medicine.
Itralase 100 Capsule contains Itraconazole, an antifungal that works by inhibiting the production of ergosterol (a main component of cell membranes of fungi). Thereby, weakens and damages the fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, it causes the main components of fungal cells to leak out, kill fungi, and clear the fungal infection.
Yes, you should swallow the capsule whole with a glass of water. Do not crush, chew or break it.
The side effects of Itralase 100 Capsule include nausea, headache, diarrhoea, stomach pain, fatigue (overtiredness), back pain, cough, and sore throat. If these side effects persist or worsen, please consult your doctor.
If you have taken overdose of Itralase 100 Capsule , please consult your doctor immediately.
Store Itralase 100 Capsule at room temperature. Protect from light and moisture. Keep out of reach and sight of children.

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - ITR0108

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