Istamet D-XR 500 Tablet is an antidiabetic medicine used to treat diabetes. It is used for the treatment of Type II Diabetes. Type II Diabetes Mellitus is a serious condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels (either not creating enough insulin, or the insulin they do make does not accomplish its purpose in the body).

Istamet D-XR 500 Tablet contains Dapagliflozin (sodium-glucose cotransporter-2 inhibitors), which removes excess sugar from the body via urine, Sitagliptin (dipeptidyl peptidase-4 inhibitor), which works by increasing the amounts of certain natural substances that lower blood sugar when it is high and Metformin (biguanides), which works by reducing the sugar production by cells in the liver and delays sugar absorption from the intestines. Diet management and exercise, along with treatment of Istamet D-XR 500 Tablet, are used to control blood sugar levels.

Istamet D-XR 500 Tablet may cause certain side effects such as vomiting, nausea, abdominal pain, headache and allergic reactions. If these side effects persist or worsen, please consult your doctor. Istamet D-XR 500 Tablet should be taken as prescribed by your doctor.

Istamet D-XR 500 Tablet should be avoided if you are allergic to any of the medicines or the components in it. Inform your doctor about your medical history and the medicines you are taking, including herbs and supplements, before starting the treatment with Istamet D-XR 500 Tablet. This can help prevent unwanted effects. Let your doctor know if you are pregnant or breastfeeding before taking Istamet D-XR 500 Tablet. It is not recommended for use in children below 18 years of age.

Istamet D-XR 500 Tablet is a combination of three drugs: Sitagliptin, Dapagliflozin and Metformin. Istamet D-XR 500 Tablet belongs to the group of anti-diabetic medicines used to treat type-2 diabetes mellitus adjunct to diet and exercise. It removes excess sugar from the body via urine, increases the amounts of certain natural substances that lower blood sugar when it is high, reduces sugar production by cells in the liver and delays sugar absorption from the intestines.

• Headache
• Nausea
• Stomach upset
• Vomiting
• Abdominal pain

Istamet D-XR 500 Tablet should be avoided if you are allergic to any of the medicines or the components in it. Before starting the treatment, inform your doctor about your medical history and the medications you take, including herbs and supplements. This can help prevent unwanted effects. Istamet D-XR 500 Tablet is not recommended for use in patients with severe liver or kidney disease. It is unknown whether Istamet D-XR 500 Tablet can be given to pregnant women or breastfeeding mothers. Hence, inform your doctor if you are pregnant or breastfeeding. It is not recommended for use in children below 18 years of age. Avoid drinking alcohol while on Istamet D-XR 500 Tablet as it increases the risk of hypoglycemia and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).

Drug-Drug Interactions: Istamet D-XR 500 Tablet interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine).

Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of a life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Istamet D-XR 500 Tablet.

Drug-Disease Interactions: Inform your doctor if you have any kidney or liver disease or heart problems.

• CEPHALEXIN
• CIMETIDINE
• DIGOXIN
• LAMOTRIGINE
• BUPROPION
• CIPROFLOXACIN
• TOPIRAMATE
• RANOLAZINE

• Try doing 30 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
• Include whole-grain foods, fruits and veggies, and other fibre-enriched foods.
• Add omega-3 fatty acid-containing oils for daily cooking.
• Avoid too much stress, as it may elevate your blood sugar level. To control stress-related blood sugar changes, you can adopt stress management techniques like mindfulness, meditation, or yoga.
• Weight loss gradually to achieve a healthy body mass index (18.5 to 24.9).
• Keep your blood pressure as normal (140/90) as possible, as it reduces the risk of cardiovascular diseases in diabetes patients.
• Avoid smoking and alcohol consumption while on treatment with Istamet D-XR 500 Tablet.
• Take short, frequent meals, and avoid prolonged fasting when taking Istamet D-XR 500 Tablet.

• Istamet D-XR 500 Tablet may sometimes cause hypoglycemia (low blood sugar levels) as a side effect. Try to carry candies or sugar biscuits in your pocket every time you feel symptoms such as sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination, etc.
• Lifestyle modifications are the most important step in controlling blood sugar levels.
• Your doctor may advise frequent blood tests to check your blood sugar levels.

Type II Diabetes Mellitus: It is a chronic and lifelong condition wherein the body doesn’t use insulin effectively, which causes unusual blood glucose levels. Therefore, people affected with type 2 diabetes either do not produce enough insulin or there is resistance to the action of insulin. Individuals middle-aged or older are most likely to suffer from type 2 diabetes, which is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, weight gain, and blurred vision.