Istamet 50 mg/1000 mg Tablet belongs to the anti-diabetic agents used to treat type II diabetes. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, insulin is produced in large amounts, but it cannot act on the body's organs.

Istamet 50 mg/1000 mg Tablet is a combination drug of Sitagliptin and Metformin. Metformin slows down the release of stored sugar from the liver, decreases the amount of sugar absorbed from the stomach, and improves how your body uses sugar. Sitagliptin increases the body's production of chemicals that cause the pancreas to release more insulin, which helps regulate blood sugar levels. Thus, Istamet 50 mg/1000 mg Tablet controls blood glucose levels from rising to very high after meals.

Istamet 50 mg/1000 mg Tablet should be taken with food to avoid an upset stomach. Istamet 50 mg/1000 mg Tablet should be taken at the same time of the day each time for best results. For better advice, your doctor will decide what dose should be taken, and it can change in time depending on your condition. The most common side effect of Istamet 50 mg/1000 mg Tablet is hypoglycemia (low blood glucose levels), characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and should also carry some form of sugar with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Istamet 50 mg/1000 mg Tablet should not be stopped even if you feel better, without consulting the doctor as your sugar level keeps changing. If you stop taking Istamet 50 mg/1000 mg Tablet abruptly, it may increase your sugar levels, which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Istamet 50 mg/1000 mg Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease, are planning to get pregnant or are breastfeeding.

Take Istamet 50 mg/1000 mg Tablet as prescribed by your doctor. Swallow it as a whole with water; do not crush, break or chew it.

Istamet 50 mg/1000 mg Tablet helps the pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar the liver makes. It helps control the rise of blood sugar levels after a meal. Besides this, it does not cause weight gain in prolonged use. Istamet 50 mg/1000 mg Tablet plays a vital role in controlling blood sugar levels. It prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

Istamet 50 mg/1000 mg Tablet should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Istamet 50 mg/1000 mg Tablet , might develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid accumulates in the blood, which can damage the workings of your liver and kidneys, which are required to eliminate excess lactic acid from the blood. Before you start taking Istamet 50 mg/1000 mg Tablet , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 levels. Istamet 50 mg/1000 mg Tablet , when used with insulin, Istamet 50 mg/1000 mg Tablet may lower the blood sugar level, leading to hypoglycaemia, which can be fatal. In this case, your doctor may adjust the dose by lowering the insulin dose or Istamet 50 mg/1000 mg Tablet . Prolonged intake of Istamet 50 mg/1000 mg Tablet may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you will have a diagnostic test with an injection of dye or X-ray contrast agent. You should stop using Istamet 50 mg/1000 mg Tablet briefly before an X-ray procedure.