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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Irinotraz 40Mg Inj is used to manage or treat Colorectal cancer (Cancer that develops in the colon or rectal tissue). It contains Irinotecan, which works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells cannot divide. As a result, Irinotecan inhibits cancer cell division and growth.

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Synonym :

IRINOTECAN HYDROCHLORIDE

Composition :

IRINOTECAN-40MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Irinotraz 40Mg Inj

Irinotraz 40Mg Inj belongs to a class of antineoplastic medications or chemotherapy drugs primarily used to manage or treat Colorectal cancer (Cancer that develops in the colon or rectal tissue). Colorectal cancer is a disease in which cells in the colon or rectum grow out of control.

Irinotraz 40Mg Inj contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can not divide. As a result, Irinotecan inhibits cancer cell division and growth.

Irinotraz 40Mg Inj should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions are nausea, vomiting, abdominal pain, diarrhoea, constipation, anorexia (an eating disorder), Neutropenia (an unusually low number of cells called neutrophils), leukopenia (including lymphocytopenia), anaemia (not having enough healthy red blood cells), asthenia (abnormal weakness), fever, weight loss, alopecia (hair loss). You should talk to your doctor if you persistently experience these side effects.

Avoid using Irinotraz 40Mg Inj if you are allergic to it. Irinotraz 40Mg Inj can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on treatment with Irinotraz 40Mg Inj. Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Irinotraz 40Mg Inj

Treatment of Colorectal cancer

Directions for Use

Irinotraz 40Mg Inj should be administered in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents.

Medicinal Benefits

Irinotraz 40Mg Inj is an antineoplastic medicine or chemotherapeutic treatment used to control or treat colorectal cancer (colon or rectal cancer). Irinotraz 40Mg Inj contains Irinotecan acts by inhibiting an enzyme known as topoisomerase I. This enzyme is required for all cells to divide and flourish. Irinotecan inhibits this enzyme, preventing cancer cells from dividing. As a result, Irinotecan inhibits cancer cell division and growth.

How Irinotraz 40Mg Inj Works

Irinotraz 40Mg Inj contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can not divide. As a result, Irinotecan inhibits cancer cell division and growth.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Irinotraz 40Mg Inj

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhoea
  • Watery eyes
  • Dizziness
  • Sweating
  • Runny nose
  • Increased saliva
  • Shrinking pupils (black circles in the middle of the eyes)
  • Constipation
  • Anorexia (an eating disorder)
  • Neutropenia (an unusually low number of cells called neutrophils)
  • Leukopenia (including lymphocytopenia)
  • Anaemia (not having enough healthy red blood cells)
  • Asthenia (abnormal weakness)
  • Fever
  • Weight loss
  • Alopecia (hair loss)

What if I have taken an overdose of Irinotraz 40Mg Inj

Since Irinotraz 40Mg Inj is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Irinotraz 40Mg Inj may cause severe neutropenia and severe diarrhoea.

Drug Warnings

Before taking the Irinotraz 40Mg Inj, let your doctor know about all your medical conditions, sensitivities, and medications you are using. Also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Before and during your therapy, your doctor will prescribe laboratory testing on a regular basis. You may also suffer severe diarrhoea (known as ''late diarrhoea'') more than 24 hours after receiving Irinotecan. Your doctor would advise you to take antidiarrheal drugs at regular intervals throughout the day and night. When taking antidiarrheal drugs, always follow your doctor's instructions. During your therapy, your doctor will also inform you which foods to take and which to avoid to reduce diarrhoea. Drink plenty of fluids and strictly adhere to this diet.

Drug-Drug Interactions

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IrinotecanKetoconazole
Critical
IrinotecanRifampicin
Severe

Drug-Drug Interactions

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IrinotecanKetoconazole
Critical
How does the drug interact with Irinotraz 40Mg Inj:
Using Irinotraz 40Mg Inj together with ketoconazole can increase the risk of side effects.

How to manage the interaction:
Taking Ketoconazole with Irinotraz 40Mg Inj is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately.
IrinotecanRifampicin
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Taking Irinotraz 40Mg Inj with rifampicin can decrease the blood levels of Irinotraz 40Mg Inj, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Irinotraz 40Mg Inj and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
IrinotecanCladribine
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Combining Cladribine with Irinotraz 40Mg Inj can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Irinotraz 40Mg Inj and Cladribine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
IrinotecanGemfibrozil
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Co-administration of Gemfibrozil with Irinotraz 40Mg Inj can increase the risk or severity of side effects like dehydration, lung or breathing problems, or bleeding problems.

How to manage the interaction:
Although taking Gemfibrozil and Irinotraz 40Mg Inj together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like diarrhea, feeling weak, blood clots, lung problems, feeling sick, throwing up, stomach pain, mouth sores, shortness of breath, looking pale, feeling tired, dizziness, fatigue, fever or chills, a sore throat, muscle pain, bleeding, bruises, losing weight, pain or burning urination consult a doctor right away. Do not discontinue any medications without consulting a doctor.
IrinotecanBaricitinib
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Taking Irinotraz 40Mg Inj with Baricitinib can increase the risk of developing serious infections as well as some cancers over time

How to manage the interaction:
There may be a possibility of interaction between Irinotraz 40Mg Inj and Baricitinib, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
IrinotecanEnzalutamide
Severe
How does the drug interact with Irinotraz 40Mg Inj:
When Enzalutamide is taken with Irinotraz 40Mg Inj, the blood levels of Irinotraz 40Mg Inj may be greatly decreased, which might diminish the effectiveness of Irinotraz 40Mg Inj in curing your cancer.

How to manage the interaction:
Co-administration of Irinotraz 40Mg Inj with Enzalutamide can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
IrinotecanCeritinib
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Taking ceritinib with Irinotraz 40Mg Inj may increase the risk of infection and other side effects.

How to manage the interaction:
Although taking Irinotraz 40Mg Inj and Ceritinib together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
IrinotecanMifepristone
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Co-administration of Irinotraz 40Mg Inj with mifepristone may significantly increase the effect of Irinotraz 40Mg Inj.

How to manage the interaction:
Taking Irinotraz 40Mg Inj with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience symptoms such as nausea, vomiting, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness or tingling, rapid heartbeat, or chest pain. Do not discontinue any medications without consulting a doctor.
IrinotecanItraconazole
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Irinotraz 40Mg Inj blood levels may be significantly raised by combining itraconazole and Irinotraz 40Mg Inj.

How to manage the interaction:
Although there is a possible interaction between Irinotraz 40Mg Inj and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
IrinotecanPosaconazole
Severe
How does the drug interact with Irinotraz 40Mg Inj:
Taking posaconazole with Irinotraz 40Mg Inj can increase the risk and severity of side effects such as nausea, vomiting, abdominal pain, diarrhea (which can lead to dehydration), mouth sores, breathing problems.

How to manage the interaction:
Although there is an interaction between Irinotraz 40Mg Inj and posaconazole, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination.. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Irinotraz 40Mg Inj Substitute

Substitutes safety advice
  • CAMPTO 40MG INJECTION 2ML

    950.85per tablet
  • Iritero-40 Injection 2 ml

    282.82per tablet
  • Relitecan-40 Inj 2Ml

    by AYUR

    675.00per tablet
  • Rinotec 40 mg Injection 1's

    1724.80per tablet
  • Foiri 40mg Injection

    1710.00per tablet
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Irinotraz 40Mg Inj.

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Pregnancy

Unsafe

Irinotraz 40Mg Inj should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Irinotraz 40Mg Inj should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Irinotraz 40Mg Inj can make you dizzy or impair your vision, especially in the first 24 hours after taking it. Do not drive or operate machinery until you know how this drug affects you.

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Liver

Caution

Irinotraz 40Mg Inj should be used with caution if you have liver disease. Inform your doctor before receiving the Irinotraz 40Mg Inj if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

It is not recommended for use in patients on dialysis. Inform your doctor before receiving the Irinotraz 40Mg Inj if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Safety and effectiveness in children have not been established. Hence, use is not recommended.

FAQs

Irinotraz 40Mg Inj is used to treat Colorectal cancer.
Irinotraz 40Mg Inj contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can't divide. As a result, Irinotecan inhibits cancer cell division and growth.
Irinotraz 40Mg Inj should not be used in patients with pulmonary diseases. So, inform your doctor if you have pulmonary disorders (lung problems).
While taking Irinotraz 40Mg Inj, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Irinotraz 40Mg Inj.
The live vaccine may not work while on treatment with Irinotraz 40Mg Inj. Only have immunizations/vaccinations after talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Irinotecan therapy may lead to Neutropenia (an unusually low number of neutrophil cells). Your doctor will order laboratory testing on a regular basis before and during your treatment.
You should know that this medicine may reduce fertility in both men and women. Discuss the risks of taking an irinotecan injection with your doctor.
You are recommended to take the advice of your doctor before taking Irinotraz 40Mg Inj. As Irinotraz 40Mg Inj is not used during pregnancy.
The common side effects of Irinotraz 40Mg Inj are nausea, vomiting, abdominal pain, diarrhoea, constipation, anorexia (an eating disorder), neutropenia (an unusually low number of cells called neutrophils), leukopenia (including lymphocytopenia), anaemia (not having enough healthy red blood cells), asthenia (abnormal weakness), fever, weight loss, alopecia (hair loss). If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - IRI0033

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