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  3. Intagesic MR Tablet 10's

Intagesic MR Tablet 10's, Pack of 10 TABLETS
Intagesic MR Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Intagesic MR Tablet is used to reduce musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). It works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Also, it helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles. It may cause side effects such as drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

CHLORZOXAZONE-250MG + DICLOFENAC-50MG + PARACETAMOL-325MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Intagesic MR Tablet

Intagesic MR Tablet is used in the reduction of musculoskeletal pain due to tissue injury, resolution of post surgery inflammation and oedema (swollen tissue with fluid). Pain can be temporary (acute) or long-term (chronic) in nature. Musculoskeletal pain can be caused due to soft tissue (muscle, tendon, and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.

Intagesic MR Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Intagesic MR Tablet can be taken with or after the meal. To avoid stomach upset Intagesic MR Tablet can be taken with food or milk. It should be swallowed whole with a glass of water. Do not take Intagesic MR Tablet if your pain lasts for more than ten days or if the fever lasts for more than three days. Do not take a double dose if you missed one dose. Like all medicines, Intagesic MR Tablet may cause side effects, although not everybody gets them. Most of the side effects of Intagesic MR Tablet are drowsiness, constipation, diarrhoea, stomach upset, slight discolouration of urine, and ringing or buzzing sounds in the ears. In case of any discomfort, speak with your doctor. 

Do not take Intagesic MR Tablet if you are allergic to painkillers like aspirin, paracetamol, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Intagesic MR Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause even more side effects on taking this drug. Consult your doctor if your symptoms of pain, inflammation and fever do not disappear even after ten days.

Uses of Intagesic MR Tablet

Treatment of Musculoskeletal pain.

Directions for Use

Take Intagesic MR Tablet as advised by your doctor. Preferably take it with a light meal. Swallow it as a whole; do not chew or crush it.

Medicinal Benefits

Intagesic MR Tablet is composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

How Intagesic MR Tablet Works

Intagesic MR Tablet is a fixed-dose combination composed of three medicines namely: Diclofenac, Paracetamol and Chlorzoxazone. Diclofenac works by blocking the action of a chemical messenger known as cyclo-oxygenase (COX), which causes pain and swelling at the injured or damaged tissue site. Paracetamol acts as a mild analgesic (mild pain reducer) and antipyretic (fever reducer), which enhances the pain relief action of Diclofenac. The third medicine, Chlorzoxazone, is a muscle relaxant that helps by blocking nerve impulses or pain sensations sent by the brain and causes relaxation of muscles.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Intagesic MR Tablet

  • Drowsiness
  • Constipation
  • Diarrhoea
  • Stomach upset
  • Slight discolouration of urine
  • Ringing or buzzing sounds in the ears

What if I have taken an overdose of Intagesic MR Tablet

Do not take more than the prescribed dose of Intagesic MR Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Intake of Intagesic MR Tablet should be avoided in liver disease (like jaundice) and cardiovascular disease (like coronary heart disease). Contact your doctor if you have signs of liver disease like feeling exhausted, dark urine, not feeling hungry, stomach pain or upset, light coloured stools or yellow skin/eyes. After taking if you have possible allergic symptoms like difficulty in breathing, difficulty in swallowing, lips/face/throat swelling, chest tightness, or skin rash, contact the doctor immediately. Ensure your doctor is aware if you are pregnant or planning to get pregnant, breastfeeding, allergic to Intagesic MR Tablet or any other painkillers like aspirin, the problem of stomach ulcer or gastric bleeding, or taking any other OTC multivitamins, multi-minerals supplements.

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
ChlorzoxazoneTapentadol
Severe

Drug-Drug Interactions

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DiclofenacMeloxicam
Critical
How does the drug interact with Intagesic MR Tablet:
Co-administration of Intagesic MR Tablet with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with Intagesic MR Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without doctor's advise.
ChlorzoxazoneTapentadol
Severe
How does the drug interact with Intagesic MR Tablet:
Taking Tapentadol with Intagesic MR Tablet can increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Taking Intagesic MR Tablet with Tapentadol can result in an interaction, it can be taken if your doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
ChlorzoxazoneMorphine
Severe
How does the drug interact with Intagesic MR Tablet:
Using Morphine together with Intagesic MR Tablet can cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Co-administration of Morphine with Intagesic MR Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
DiclofenacIbuprofen
Severe
How does the drug interact with Intagesic MR Tablet:
Taking Intagesic MR Tablet and ibuprofen can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Co-administration of Intagesic MR Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacSulindac
Severe
How does the drug interact with Intagesic MR Tablet:
Co-administration of Intagesic MR Tablet and sulindac can increase the risk of side effects.

How to manage the interaction:
Although there is a interaction between Intagesic MR Tablet and sulindac, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacCelecoxib
Severe
How does the drug interact with Intagesic MR Tablet:
Co-administration of Intagesic MR Tablet with Celecoxib may increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although there is a interaction between Intagesic MR Tablet and Celecoxib, but it can be taken if your doctor has advised it. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Do not discontinue any medication without consulting a doctor.
DiclofenacDasatinib
Severe
How does the drug interact with Intagesic MR Tablet:
Taking Dasatinib together with Intagesic MR Tablet may increase the risk of bleeding.

How to manage the interaction:
There may be a possible interaction between Intagesic MR Tablet and Dasatinib but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you experience dizziness, red or black, tarry stools, or severe headaches. Do not discontinue any medications without consulting a doctor.
DiclofenacAcalabrutinib
Severe
How does the drug interact with Intagesic MR Tablet:
Taking acalabrutinib together with Intagesic MR Tablet may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Intagesic MR Tablet and Acalabrutinib can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
DiclofenacFurosemide
Severe
How does the drug interact with Intagesic MR Tablet:
Concomitant administration of Intagesic MR Tablet and furosemide may decrease the therapeutic efficacy of furosemide and adversely affect renal function.

How to manage the interaction:
There may be a possible interaction between Intagesic MR Tablet and furosemide, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience symptoms like nausea, dizziness, irregular heartbeats, altered blood pressure, tingling. Do not stop using any medications without first talking to your doctor.
DiclofenacEnoxaparin
Severe
How does the drug interact with Intagesic MR Tablet:
Taking Intagesic MR Tablet with Enoxaparin can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possible interaction between Intagesic MR Tablet and Enoxaparin, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Intagesic MR Tablet is commonly prescribed for relieving pain in both acute and chronic conditions and in cases of fever. Do not take the drug beyond its suggested dose and frequency.
  • Avoid driving while consuming Intagesic MR Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes.
  • Avoid concomitant consumption of drugs containing the same chemicals as Intagesic MR Tablet as it can lead to overdosage and unwanted side effects.
  • Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Intagesic MR Tablet .
  • Avoid consuming alcohol while you are on Intagesic MR Tablet .

Habit Forming

No

Therapeutic Class

ANALGESICS

Intagesic MR Tablet Substitute

Substitutes safety advice

  • Diclofam-MR Tablet 10's

    by Others

    ₹12.30per tablet

  • Powergesic Tablet 10's

    by Others

    ₹13.41per tablet

  • Lobak Tablet 10's

    by Others

    ₹7.88per tablet

  • Dan MR Tablet 10's

    by Others

    ₹4.73per tablet

  • Alde Plus CX Tablet 10's

    by AYUR

    ₹21.60per tablet

Product Substitutes

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Alcohol

Caution

Alcohol should not be consumed with Intagesic MR Tablet as it leads to excessive drowsiness

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Pregnancy

Caution

Only consume Intagesic MR Tablet , if you are prescribed by a doctor

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Breast Feeding

Caution

Intagesic MR Tablet does not pass on to the child significantly via breast milk, consult your doctor before using Intagesic MR Tablet .

bannner image

Driving

Caution

Intagesic MR Tablet may affect driving ability as it causes dizziness.

bannner image

Liver

Caution

Intagesic MR Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. Dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Intagesic MR Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

bannner image

Children

Caution

Intagesic MR Tablet is not recommended for children below 12 years of age without doctor's consent. For children above 12 years, dose to be adjusted and recommended by a child specialist only.

FAQs

Intagesic MR Tablet is used to treat musculoskeletal pain due to tissue injury, post-surgery inflammation and oedema (swollen tissue with fluid).

No, Intagesic MR Tablet should not be taken as a long term medication as it may lead to stomach ulcers/bleeding and kidney problems. For best results of Intagesic MR Tablet , take it in doses and duration mentioned by your doctor.

No, it is not advisable to take Intagesic MR Tablet with depression medication. Please inform your doctor if you are taking depression medicine before starting Intagesic MR Tablet .

Yes, Intagesic MR Tablet is a short term medication and if you feel better you can stop taking Intagesic MR Tablet , but only after consulting your doctor.

Intagesic MR Tablet is known to be contra-indicated in patients with allergy to painkillers (NSAIDs) or any of the components or excipients of this medicine. Its use should also be avoided in patients with history of stomach ulcer and kidney/liver disease.

No, Intagesic MR Tablet is not indicated for stomach pain. Also, If you have stomach pain post ingestion it may be a sign of stomach ulcer or gastric bleeding. Do not take Intagesic MR Tablet in this condition. It is better to inform your doctor in case of stomach pain post ingestion of this medication.

It depends on whether your cough and cold pills contains diclofenac, paracetamol and Chlorzoxazone or not. If it contains these three medicines, do not take it. It may lead to overdosage, thereby producing unpleasant side effects. Consult your doctor before taking it in such cases.

No, do not take Intagesic MR Tablet until prescribed by your doctor. For example, your shoulder pain may be due to lungs, spleen or gallbladder problem. Your back pain may be due to kidney stone, pancreas swelling, or in women, pelvic disorders. Your arm pain (especially left arm) may be due to heart attack (myocardial infarction).

Intagesic MR Tablet is a combination of a muscle relaxant (Chlorzoxazone) and two pain relieving medicines (Diclofenac and Paracetamol).

Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimise side effects.

Intagesic MR Tablet is not intended to treat toothache. It is used to reduce musculoskeletal pain.

Avoid simultaneous consumption of other painkillers or cough and cold medicines with this Intagesic MR Tablet , as it may lead to an overdose.

No, it is not indicated to treat gastritis. It may worsen your condition.

It may help ease pain associated with period pain. However, it should only be used if recommended by the doctor.

It may help ease headaches. However, it should be used only if recommended by the doctor.

Intagesic MR Tablet usually takes effect within 30 minutes to an hour of intake.

No, it does not contain steroids. It combines one muscle relaxant medication and two pain relieving medicines.

Yes, in some cases, Intagesic MR Tablet may cause acidity.

Yes, Intagesic MR Tablet may cause drowsiness, although not everybody gets it. If you experience any discomfort, speak with your doctor.

No, Intagesic MR Tablet is not intended to treat loose motion. It is meant to treat musculoskeletal pain.

Yes, it can be used to treat tissue or ligament injury. However, it should be used only if recommended by a doctor.

Intagesic MR Tablet may cause constipation, although not everybody gets it. If you experience any discomfort, speak with your doctor.

Intagesic MR Tablet is safe if used as advised by the doctor. Follow your doctor's instructions.

It may cause common side effects like nausea and vomiting in some patients, although not everybody gets them. If you experience any discomfort, speak with your doctor.

Yes, it may lead to dizziness, although not everybody gets it. If you experience any discomfort, consult your doctor.

Yes, long-term usage of Intagesic MR Tablet may be harmful to the kidney.

Store in a cool and dry place away from sunlight. Keep out of the sight and reach of children.

Yes, it should be taken with food or after food.

Intagesic MR Tablet should not be used during pregnancy and by nursing mothers unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Intagesic MR Tablet .

Intagesic MR Tablet is not recommended for children below 12 years of age without a doctor's consent. For children above 12 years, the dose is to be adjusted and recommended by a child specialist only.

Alcohol should not be consumed with Intagesic MR Tablet as it leads to excessive drowsiness.

Take the missed dose as soon as you remember unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - INT0001

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Author Details

Doctor imageDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:50 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.unitedpharmacies.md/Dicoliv-MR-Diclofenac-Potassium-Paracetamol-Chlorzoxazone.html
  2. https://www.medicines.org.uk/emc/files/pil.2660.pdf
  3. https://www.medicines.org.uk/emc/files/pil.10547.pdf
  4. https://www.accessdata.fda.gov/drugsatfda_docs/psg/PSG_011300.pdf
  5. https://www.sciencedirect.com/topics/neuroscience/chlorzoxazone
  6. https://www.nhs.uk/conditions/nsaids/
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