Insuman Comb 25 Injection 3 ml is a combination of two medicines, an intermediate-acting and a short-acting type of insulin, primarily used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children.  Diabetes mellitus is a condition that affects the way your body processes glucose. In Diabetes Mellitus Type 1, the body does not make enough insulin to control blood sugar levels. In Diabetes Mellitus type 2, either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood), or there is resistance to the action of insulin. As a result, insulin is produced in large amounts but it is not able to act on the organs of the body.

Insuman Comb 25 Injection 3 ml is a combination of two drugs one is insulin human (a short-acting type of insulin) and the other is insulin isophane (intermediate-acting). Insulin human is a hormone known as 'insulin' made in your pancreas, which helps your body utilize glucose (sugar) for energy. Insulin Isophane contains human insulin, used to improve blood sugar control in adults and children with type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in both adults and children. Insuman Comb 25 Injection 3 ml helps to lower the blood sugar (glucose) level by facilitating the uptake of glucose. It is followed by the binding of insulin to the cells of muscle and fat cells, thereby inhibiting glucose release from the liver. Thus, together Insuman Comb 25 Injection 3 ml helps to decrease blood glucose levels after the intake of meals. Besides this, it also prevents the chances of developing serious complications of diabetes, like damage to the retina (retinopathy), damage to the kidney (nephropathy), damage of nerve cells (neuropathy), diabetic foot ulcer, and others.

Take Insuman Comb 25 Injection 3 ml as prescribed by your doctor. You are advised to take Insuman Comb 25 Injection 3 ml as long as your doctor has prescribed it for you, depending on your medical conditions. You may experience an allergic reaction at the site of injection, hypoglycemia (low blood glucose level), itching, lipodystrophy (skin thickening or pits at the injection site), oedema (swelling), rashes, and weight gain. Most of these side effects of Insuman Comb 25 Injection 3 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

In type 1 diabetes, untreated high blood sugar levels can lead to a life-threatening condition known as diabetic ketoacidosis. Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Do not take this medicine if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. Along with this medicine, you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor. Insuman Comb 25 Injection 3 ml is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius, or else its efficiency may be lost. Do not store it in the freezer of the refrigerator.

When you take Insuman Comb 25 Injection 3 ml, it works by ensuring rapid and consistent sugar control. It facilitates the reuptake of sugar in muscle and fat cells and also suppresses the production of sugar in the liver.  It prevents the chances of developing serious complications of diabetes. Besides this, Insuman Comb 25 Injection 3 ml can be safely prescribed to the diabetic mother in the pregnancy as well as the lactation stage. Insuman Comb 25 Injection 3 ml helps in improving glycaemic control, which in turn decreases the risk of progression of complications of diabetes like damage to the retina (retinopathy), damage of kidney (nephropathy), damage of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer, and others.

• Allergic reaction at the site of injection

• Hypoglycemia (low blood glucose level)

• Itching

• Lipodystrophy (skin thickening or pits at the injection site)

• Edema (swelling)

• Rashes

• Weight gain

Insuman Comb 25 Injection 3 ml is for subcutaneous use only and should never be administered intravenously (IV) or in the veins. If you are changing the brand of insulin, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin especially in patients who are at high risk of cardiac heart failure. The first symptoms of hyperglycemia (high blood sugar level) may include symptoms like excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and acetone odor of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain, and edema (fluid deposition in tissue) should not be overruled. You are recommended not to consume alcohol as it may elevate blood glucose levels. Care should be taken when you are traveling across more than 2 time zones. Your doctor may adjust your insulin schedule. Insuman Comb 25 Injection 3 ml may decrease the level of potassium leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take this medicine if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. 

Drug-Drug Interaction: This medicine may have an interaction with anti-depressants (phenelzine, iproniazid, isocarboxazid, nialamide, imipramine, desipramine, tranylcypromine, moclobemide), anti-Parkinson’s drug (selegiline), antibiotic (linezolid), (lithium, tryptophan), migraines drug (sumatriptan), pain killer (tramadol), anti-ulcer (cimetidine, lansoprazole, omeprazole), anti-fungal (fluconazole), anti-stroke pills (ticlopidine), blood-thinners (warfarin, dipyridamole, and phenprocoumon), antimalarial (mefloquine), heart-related drug (flecainide, propafenone), and medicines that decrease blood levels of potassium or magnesium, as these increase the risk of life-threatening heart rhythm disorder. Besides this, the use of oral antidiabetic pills like pramlintide acetate and antibiotics (pentamidine) may cause hypoglycemia (low blood sugar level).

Drug-Food Interaction: Insuman Comb 25 Injection 3 ml may interact with an ayurvedic, homeopathy, Unani, herbal supplements, or OTC items. Tell your doctor if you are using these products. Try to avoid intake of alcoholic beverages with Insuman Comb 25 Injection 3 ml as it may lower blood sugar level (hypoglycemia).

Drug-Disease Interaction: Insuman Comb 25 Injection 3 ml should not be given to patients with kidney disease, liver disease, low potassium level (hypokalaemia), and low blood sugar/glucose level (hypoglycemia).

• PHENELZINE
• ISOCARBOXAZID
• IMIPRAMINE
• DESIPRAMINE
• TRANYLCYPROMINE
• MOCLOBEMIDE
• SELEGILINE
• LINEZOLID
• LITHIUM
• SUMATRIPTAN
• TRAMADOL
• CIMETIDINE
• LANSOPRAZOLE
• OMEPRAZOLE
• FLUCONAZOLE
• TICLOPIDINE
• WARFARIN
• MEFLOQUINE

• Exercise may lower your body’s need for insulin during and for some time after the physical activity.
• Exercise may also speed up the effect of an insulin dose, especially if the exercise involves the area of the injection site (for example, the leg should not be used for injection just prior to running).
• Avoid eating sugar food and prefer food cooked food low in calories.
• While traveling across more than 2 time zones, you should talk to your doctor concerning adjustments in your insulin schedule.

If you feel any symptoms of Hypoglycemia (fatigue, dizziness ,Confusion, heart palpitations, shakiness and anxiety), consult your doctor immediately.  

In type 1 diabetes mellitus our body does not make insulin (the hormone which helps to decrease sugar levels in the blood) to control blood sugar levels.

In type 2 diabetes mellitus, either the body stops producing enough insulin, or there is resistance to the action of insulin. As a result, insulin is produced in sufficient amounts but is unable to act on the tissues of the organs.