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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Instgra Tablet contains Dolutegravir, which belongs to a group of antiretroviral medicines indicated for the treatment of HIV infection. Instgra Tablet reduces the viral load in the body and keeps it at a low level. It also increases the count of CD4 cells, which are white blood cells that help the body fight infection. Sometimes, Instgra Tablet may cause side effects such as nausea, vomiting, headache, and diarrhoea.

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Composition :

DOLUTEGRAVIR-50MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Instgra Tablet

Instgra Tablet belongs to a group of antiretroviral medicines called HIV integrase inhibitors indicated for the treatment of HIV infection. Instgra Tablet does not cure HIV infection. It reduces the viral load in the body and keeps it at a low level. Taking Instgra Tablet decreases the chance of developing AIDS (acquired immunodeficiency syndrome) and HIV-related illnesses such as cancer or serious infections.

Instgra Tablet contains Dolutegravir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body fight infection.

In some cases, Instgra Tablet may cause side effects such as nausea, vomiting, headache, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually. However, you are advised to talk to the doctor if the side effects persist or worsen.

Pregnancy testing should be performed in adolescents and adults of reproductive potential prior to starting Dolutegravir to rule out the use of Dolutegravir during the first trimester of pregnancy. Advise adolescents and adults with reproductive potential to take effective contraception on a regular basis. Avoid breastfeeding whilst on treatment with Instgra Tablet . Instgra Tablet may cause dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medications to prevent side effects/interactions.

Uses of Instgra Tablet

Treatment of HIV infection

Directions for Use

Take Instgra Tablet with or without food. Swallow it as a whole with water; do not chew or crush it.

Medicinal Benefits

Instgra Tablet contains Dolutegravir, which belongs to a group of antiretroviral medicines indicated for the treatment of HIV infection. Instgra Tablet reduces the viral load in the body and keeps it at a low level. It also increases the count of CD4 cells, a type of white blood cells that help the body fight infection.

How Instgra Tablet Works

Instgra Tablet contains Dolutegravir, which works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body fight infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Instgra Tablet

  • Nausea
  • Vomiting
  • Headache
  • Diarrhoea
  • Abdominal pain or discomfort
  • Dizziness
  • Fatigue
  • Flatulence (wind)

What if I have taken an overdose of Instgra Tablet

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Instgra Tablet or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

Do not take Instgra Tablet if you are allergic to any of its components or if you are taking fampridine (used in multiple sclerosis) or dofetilide (used to treat heart conditions). Inform your doctor if you notice joint pain, bone problems, and stiffness or symptoms of infection/inflammation, such as fever, headache, stomach ache, and difficulty breathing. Let the doctor know if you are taking prescription/non-prescription medicines, including herbal products or supplements.

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
DolutegravirKaolin
Severe

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
How does the drug interact with Instgra Tablet 30's:
Taking Instgra Tablet 30's with dofetilide may possibly reduce the blood levels and effects of Instgra Tablet 30's. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Instgra Tablet 30's with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
DolutegravirKaolin
Severe
How does the drug interact with Instgra Tablet 30's:
Taking Instgra Tablet 30's with kaolin can reduce the effectiveness of Instgra Tablet 30's.

How to manage the interaction:
Although taking Instgra Tablet 30's and Kaolin together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet 30's either two hours before or six hours after taking a dose of Kaolin. Do not discontinue using any medications without consulting a doctor.
DolutegravirMagaldrate
Severe
How does the drug interact with Instgra Tablet 30's:
Taking Instgra Tablet 30's with magaldrate can reduce the effectiveness of Instgra Tablet 30's.

How to manage the interaction:
Although taking Instgra Tablet 30's and Magaldrate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet 30's either two hours before or six hours after taking a dose of Magaldrate. Do not discontinue using any medications without consulting a doctor.
DolutegravirCalcium carbonate
Severe
How does the drug interact with Instgra Tablet 30's:
Co-administration of Instgra Tablet 30's with Calcium carbonate can reduce the effectiveness of Instgra Tablet 30's.

How to manage the interaction:
Although there is an interaction, calcium carbonate can be taken with Instgra Tablet 30's if prescribed by the doctor. However, Instgra Tablet 30's and calcium carbonate should not be taken orally at the same time. Maintain a gap of 2-6 hours between both medicines. Do not discontinue using any medications without consulting a doctor.
DolutegravirCalcium lactate
Severe
How does the drug interact with Instgra Tablet 30's:
Co-administration of Instgra Tablet 30's with Calcium lactate can reduce the effectiveness of Instgra Tablet 30's.

How to manage the interaction:
Although there is an interaction, Calcium lactate can be taken with Instgra Tablet 30's if prescribed by the doctor. However, Instgra Tablet 30's and calcium carbonate should not be taken orally at the same time. Maintain a gap of 2-6 hours between both medicines. Do not discontinue using any medications without consulting a doctor.
DolutegravirMagnesium oxide
Severe
How does the drug interact with Instgra Tablet 30's:
Taking Instgra Tablet 30's with magnesium oxide can reduce the effectiveness of Instgra Tablet 30's.

How to manage the interaction:
Taking Magnesium oxide with Instgra Tablet 30's together can result in an interaction, it can be taken if your doctor has advised it. However, take Instgra Tablet 30's at least two hours before or six hours after the magnesium oxide dose. Do not stop using any medications without talking to a doctor.
DolutegravirSodium bicarbonate
Severe
How does the drug interact with Instgra Tablet 30's:
Co-administration of Sodium bicarbonate and Instgra Tablet 30's reduces the levels of Instgra Tablet 30's, resulting in reduced effectiveness.

How to manage the interaction:
Although taking Instgra Tablet 30's and Sodium bicarbonate together can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, and pain or burning during urination, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DolutegravirMagnesium lactate
Severe
How does the drug interact with Instgra Tablet 30's:
Taking Instgra Tablet 30's with magnesium lactate can reduce the effectiveness of Instgra Tablet 30's.

How to manage the interaction:
Although taking Instgra Tablet 30's and Magnesium lactate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet 30's either two hours before or six hours after taking a dose of Magnesium lactate. Do not discontinue using any medications without consulting a doctor.
DolutegravirCalcium citrate
Severe
How does the drug interact with Instgra Tablet 30's:
Co-administration of Instgra Tablet 30's with Calcium citrate can reduce the effectiveness of Instgra Tablet 30's.

How to manage the interaction:
Although there is an interaction, Calcium citrate can be used with Instgra Tablet 30's if prescribed by the doctor. However, take Instgra Tablet 30's at least two hours before or six hours after calcium citrate. Do not discontinue the medication without consulting a doctor.
DolutegravirFosamprenavir
Severe
How does the drug interact with Instgra Tablet 30's:
Coadministration of Instgra Tablet 30's and fosamprenavir may decrease the blood levels of Instgra Tablet 30's.

How to manage the interaction:
Although taking Instgra Tablet 30's and Fosamprenavir together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not discontinue using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Practise safe sex by using condoms; it helps in reducing contact with semen and vaginal fluids.
  • Never share personal items that can have body fluids or blood on them, such as razor blades or toothbrushes.
  • Avoid sharing used needles, other injections or drug equipment.
  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food, vegetables and fruits as it helps to boost your immune system. Opt for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry or seafood.
  • Eat bland and low-fat foods. Avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or doing whatever makes you happy.

Habit Forming

No

Therapeutic Class

ANTIRETROVIRAL AGENTS

Instgra Tablet Substitute

Substitutes safety advice
  • Auroteg-50 Tablet 30's

    88.61per tablet
  • Xapavir 50 Tablet 30's

    97.44per tablet
  • Dalimune 50mg Tablet

    75.00per tablet
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Alcohol

Consult your doctor

It is not known whether Instgra Tablet interacts with alcohol. Please consult your doctor.

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Pregnancy

Caution

Instgra Tablet may increase the risk of birth defects. Please consult the doctor if you are pregnant. Your doctor will weigh the benefits and potential risks before prescribing Instgra Tablet .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Instgra Tablet . HIV-positive women must not breastfeed as HIV infection can be passed to the baby in breast milk.

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Driving

Caution

Instgra Tablet may cause dizziness. Drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Limited information is available. Please consult your doctor if you have liver problems. Your doctor will weigh the benefits and potential risks before prescribing Instgra Tablet .

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Kidney

Consult your doctor

Limited information is available. Please consult your doctor if you have kidney problems. Your doctor will weigh the benefits and potential risks before prescribing Instgra Tablet .

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Children

Caution

Please consult the doctor if you have any concerns regarding the usage of Instgra Tablet in children.

FAQs

Instgra Tablet is used to treat HIV infection.
Instgra Tablet works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body to fight infection.
Antacids used to treat heartburn or indigestion, multivitamins, calcium or iron supplements may stop the absorption of Instgra Tablet and make it less effective. Therefore, do not take antacid, multivitamins, calcium or iron supplements 6 hours before and 2 hours after taking Instgra Tablet . However, consult the doctor before taking other medicines while on treatment with Instgra Tablet .
Few people taking combination therapy for HIV may develop osteonecrosis. Consult the doctor if you experience symptoms of osteonecrosis, such as stiffness in the joints, joint pain or aches, and difficulty moving.

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - INS0254

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