Inonza 1 mg Injection is an anti-cancer medicine used in the treatment of acute lymphoblastic leukemia, a blood cancer that primarily affects the blood and bone marrow. Inonza 1 mg Injection is used in the treatment of patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).

Inonza 1 mg Injection contains Inotuzumab Ozogamicin, which belongs to the class of monoclonal antibodies. It works by inhibiting the DNA and RNA transcription that is essential for cancer cell growth. This helps prevent the growth and further spread of cancerous or non-cancerous cells.

Inonza 1 mg Injection may cause certain side effects, such as skin rash, fatigue, headache, decreased platelet count, nausea, vomiting, diarrhea, abdominal pain, dizziness, myalgia, and injection site reactions. These side effects do not require medical attention and gradually resolve over time. Inonza 1 mg Injection is a parenteral preparation. It will be administered by a trained oncologist. Do not self-administer.

Inonza 1 mg Injection should be avoided if you are allergic to it or any other components present in it. Before taking Inonza 1 mg Injection, caution should be exercised if you have/had liver/kidney disease, gastrointestinal disorders, or cardiac problems, as it may cause serious side effects or worsen such conditions. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant, planning to become pregnant or are breastfeeding before starting the treatment.

Inonza 1 mg Injection contains Dasatinib, which is used in the treatment of acute lymphoblastic leukemia (ALL). It works by binding the ADC (antibody-drug conjugate) and CD22 tumor cells containing N-acetyl-gamma-calicheamicin (cytotoxic agent) and forms the ADC-CD22 complex. This complex causes the activation of N-acetyl-gamma-calicheamicin and induces DNA breakage. Thus, it helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body.

• Nausea
• Diarrhoea
• Decreased platelet count
• Fatigue
• Vomiting
• Headache
• Abdominal pain
• Dizziness
• Skin rash
• Myalgia
• Pain at the site of injection
• Injection site reactions

Inonza 1 mg Injection should be avoided if you are allergic to it or any other components present in it. Before taking, inform your doctor if you have liver/kidney disease, diabetes, cardiac problems, or increased blood pressure, as the use of Inonza 1 mg Injection in these patients may cause serious side effects. This medicine is known to cause embryo-fetal toxicity. Hence, inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment. Breastfeeding should be discontinued in nursing mothers during the treatment. Inonza 1 mg Injection is given in children above one year of age only if prescribed by the doctor. Inonza 1 mg Injection may cause myelosuppression, QT prolongation, hepatotoxicity, Hepatic Veno-occlusive Disease (Sinusoidal Obstruction Syndrome), and Increased Risk of Post-HSCT Non-Relapse Mortality in some patients. Hence, inform your doctor about your complete medical and medication history before receiving this medicine. Avoid alcohol consumption and smoking, which can lead to serious adverse effects.

Drug-Drug Interactions: Inonza 1 mg Injection may interact with immunosupressants (adalimumab, infliximab, natalizumab), antiviral medicine (saquinavir, efavirenz), live vaccines, antipsychotics (haloperidol, droperidol, clozapine), antidepressants (citalopram, escitalopram), etc.

Drug-Food Interactions: Avoid alcohol consumption and smoking. 

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, , diabetes, and cardiac disorders before taking Inonza 1 mg Injection.

• CLOZAPINE
• CITALOPRAM
• ESCITALOPRAM
• NATALIZUMAB
• SAQUINAVIR
• EFAVIRENZ
• HALOPERIDOL
• DROPERIDOL
• ADALIMUMAB
• INFLIXIMAB

• After beginning your treatment, several dietary adjustments can help you control side effects.
• Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
• Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
• Eat a healthy diet and exercise regularly to maintain proper weight.
• Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Get optimal sleep; rest well.
• Avoid smoking and alcohol consumption.
• Avoid fast and fried food, processed meats, refined carbs and added sugars.

• A blood test, such as LFT and RFT, should be performed to check for liver/kidney function.
• Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).
• An ECG and ECHO should be done in patients taking Inonza 1 mg Injection to check for any signs of cardiac problems.

Acute Lymphoblastic Leukemia (ALL): Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections. There are different types of blood cancers.  ALL is a type of blood cancer that primarily affects your blood and bone marrow. It mainly targets the white blood cells, which can interfere with your body’s ability to combat infections. Symptoms may include fever, weight loss, abnormal blood cell count, bruising, and loss of appetite.