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Imfinzi 120 mg Infusion 2.4 ml

Imfinzi 120 mg Infusion 2.4 ml

Prescription drug
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Composition

DURVALUMAB-120MG

Manufacturer/Marketer

Astra Zeneca Pharma India Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-25

for this medicine

About Imfinzi 120 mg Infusion

Imfinzi 120 mg Infusion is an anti-cancer medicine used in the treatment of unresectable, stage III non-small cell lung cancer (NSCLC). Imfinzi 120 mg Infusion is also used in combination with tremelimumab-actl and platinum-based chemotherapy for treatment of metastatic NSCLC, in combination with etoposide and either carboplatin or cisplatin for treating extensive-stage small cell lung cancer, in combination with gemcitabine and cisplatin in treating metastatic biliary tract cancer, and in combination with tremelimumab-act in treatment of unresectable hepatocellular cancer.

Imfinzi 120 mg Infusion contains Durvalumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1), thereby stopping the abnormal growth of cancer cells.

Imfinzi 120 mg Infusion may cause certain side effects such as diarrhoea, nausea, vomiting, tiredness, itching, rash, headache, fever, shortness of breath, muscle/joint pain, abdominal pain, loss of appetite and injection site reactions. Inform your doctor if any of these side effects persist for longer. Imfinzi 120 mg Infusion will be administered by an oncologist trained in administering anti-cancer agents. 

Avoid receiving Imfinzi 120 mg Infusion and inform your doctor if you are allergic to it or any other components of it. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy. Before taking Imfinzi 120 mg Infusion , tell your doctor if you have/had liver or kidney disease, autoimmune disorders such as ulcerative colitis or Crohn's disease, a history of organ transplants, received an allogeneic stem cell transplant, or had radiation treatment to the chest, and myasthenia gravis. Avoid breastfeeding while taking this Imfinzi 120 mg Infusion .

Uses of Imfinzi 120 mg Infusion

Treatment of Non-small cell lung cancer, Hepatocellular carcinoma and Biliary tract cancer

Medicinal Benefits

Imfinzi 120 mg Infusion contains Durvalumab, which is used in the treatment of different types of cancers. It works by inhibiting the action of a programmed death ligand receptor-1 (PD-L1) that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other body parts.

Directions for Use

Imfinzi 120 mg Infusion will be administered by a trained oncologist in the hospital setting. Hence, do not self-administer. Your doctor will decide the dose and duration of the treatment based on the severity and type of cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Imfinzi 120 mg Infusion

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Weakness
  • Muscle pain
  • Cough
  • Headache
  • Fever
  • Itching
  • Rash
  • Back pain
  • Upper respiratory tract infections
  • Injection site reactions

Drug Warnings

To treat your condition effectually, continue receiving Imfinzi 120 mg Infusion for the period that your doctor has prescribed. Imfinzi 120 mg Infusion may cause severe immune-mediated adverse reactions (IMAR) such as immune-mediated colitis, hepatitis, hepatotoxicity, nephritis, endocrinopathies, pneumonitis, cardiac problems, and dermatologic reactions. It may also cause infusion-related reactions in some patients. Therefore, caution should be exercised if you have/had liver or kidney disease, any history of organ transplant, gastrointestinal disorders, autoimmune disorders such as ulcerative colitis or Crohn’s disease, lung disease, heart problems, and breathing difficulty while receiving Imfinzi 120 mg Infusion . This medicine may also cause severe infusion-related reactions. Hence, careful monitoring is recommended and discontinue the treatment if any severe infusion reactions occur. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. This medicine is not recommended for use in children below 12 years of age as the safety and efficacy are not established.

Drug Interactions

Drug-Drug Interactions: Imfinzi 120 mg Infusion may have interaction with immunomodulator drugs (thalidomide), corticosteroids (prednisolone, methylprednisolone, prednisone), etc.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Dug-Disease Interactions: Tell your doctor if you have liver or kidney disease, heart problems, GI disorders, dermatitis, or a weak immune system before starting the treatment.

Drug-Drug Interactions Checker List

  • THALIDOMIDE
  • PREDNISOLONE
  • PREDNISONE
  • METHYLPREDNISOLONE

Habit Forming

No

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Special Advise

  • Your doctor may suggest periodic liver function tests, kidney function tests, and lung function tests to monitor the function of the liver, kidney and lungs due to the use of Imfinzi 120 mg Infusion .
  • Using contraceptive pills while using Imfinzi 120 mg Infusion to prevent pregnancy is advised.
  • Thyroid function and adrenocorticotropic hormone levels will be monitored during treatment to avoid any life-threatening side effects.

Disease/Condition Glossary

Non-Small Cell Lung Cancer (NSCLC): It is the most common form of lung cancer, which occurs when cells that form the lining of the lung start growing uncontrollably. It is mostly seen in persons who smoke. Symptoms may include chest pain, weight loss, hoarseness, and difficulty breathing.

Hepatocellular carcinoma: It occurs when the cancer/ malignant cells grow out of control in the liver. This infects the liver, destroys the liver cells and affects the ability of the liver to work properly. Symptoms may include abdominal pain, loss of appetite, weight loss, and pale bowel motions.

Biliary tract cancer: Also known as bile duct cancer or Cholangiocarcinoma. It is a rare type of cancer in which the cancer cells grow abnormally in the epithelial cells lining the biliary tract. Symptoms may include abdominal pain, itching, fever, weight loss, changes in the colour of urine and stools, and jaundice.

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Alcohol

Consult your doctor

It is unknown whether Imfinzi 120 mg Infusion interacts with alcohol. Consult your doctor for more information.

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Pregnancy

Unsafe

Imfinzi 120 mg Infusion is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Imfinzi 120 mg Infusion . You should not become pregnant while you are receiving Imfinzi 120 mg Infusion for at least three months from the last dose of Imfinzi 120 mg Infusion . Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Imfinzi 120 mg Infusion should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least three months from the last dose of medicine.

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Driving

Caution

Imfinzi 120 mg Infusion will be administered to hospitalized patients. Driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before receiving this medicine. Inform your doctor if you experience any symptoms, such as severe nausea or vomiting, right-sided upper stomach pain, easy bruising or bleeding, dark urine, or jaundice (yellowing of the skin or eyes). Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Imfinzi 120 mg Infusion . Tell your doctor if you have little or no urination, swelling in your feet or ankles, or blood in your urine. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Imfinzi 120 mg Infusion is not recommended for use in children below 12 years as the safety and efficacy are not established.

Country of origin

India

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12Th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - IMF0013

FAQs

Imfinzi 120 mg Infusion is used to treat Non-small cell lung cancer, Hepatocellular carcinoma and Biliary tract cancer.
Imfinzi 120 mg Infusion contains Durvalumab, which works by inhibiting the action of a programmed death receptor-1 (PD-L1) that causes the multiplication of cancerous cells.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

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