Ibutran Plus 400 mg/500 mg/25 mg Tablet is used to relieve pain. Pain can be temporary (acute) or long-lasting (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or other organs. Chronic pain lasts for a long duration and is caused by pathologies like nerve damage, osteoarthritis, etc. Besides this, it is also useful for dental pain, which can occur due to damage to the tooth nerve, infection, decay, extraction, or injury.

Ibutran Plus 400 mg/500 mg/25 mg Tablet is composed of three medicines: Ibuprofen, Paracetamol and Caffeine. Together, they relieve symptoms of arthritis and dysmenorrhea (painful periods or menstrual cramps) and reduce fever. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Caffeine acts as a common stimulant, added to speed up the action of ibuprofen and paracetamol in relieving pain and reducing inflammation. Together all these three medicines help in reducing mild to moderate pain in a shorter duration.

Ibutran Plus 400 mg/500 mg/25 mg Tablet can be taken with or after the meal. If stomach upset or irritation occurs, it is advisable to take Ibutran Plus 400 mg/500 mg/25 mg Tablet with food or milk. It should be swallowed whole with a glass of water. Do not crush or chew the tablets. Do not take Ibutran Plus 400 mg/500 mg/25 mg Tablet if your pain lasts for more than ten days or if the fever lasts for more than three days. Do not take a double dose if you missed one dose. Like all medicines, Ibutran Plus 400 mg/500 mg/25 mg Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate and or in case of any signs of hypersensitivity.

Do not take Ibutran Plus 400 mg/500 mg/25 mg Tablet if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease, or gastric ulcers/bleeding problems. Ibutran Plus 400 mg/500 mg/25 mg Tablet may be associated with a small increase in the risk of heart attack (myocardial infarction). Avoid consumption of alcohol as it may damage your liver and cause increased side effects on taking this drug. Consult your doctor if your symptoms of pain, inflammation, and fever do not disappear even after ten days.

Ibutran Plus 400 mg/500 mg/25 mg Tablet is composed of ibuprofen, caffeine and paracetamol primarily used to treat mild to moderate pain. Ibutran Plus 400 mg/500 mg/25 mg Tablet is prescribed mainly to treat pain and get relief from discomfort caused by conditions like tooth pain, arthritis, period pain, and other types of short-term pains. It helps in treating pain by blocking the chemical messenger in the brain responsible for causing pain. Ibuprofen works by blocking the effect of a chemical known as prostaglandin responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting the synthesis of prostaglandin by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat, and caffeine helps in reduce drowsiness caused by paracetamol. Paracetamol has the advantage of producing less gastric irritation compared to other painkillers like aspirin.

• Nausea
• Indigestion
• Stomach pain
• Restlessness

Ibutran Plus 400 mg/500 mg/25 mg Tablet should be taken with caution if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent bypass heart surgery, heart disease, or a history of allergy to any painkillers or analgesics. Caffeine can pass in the breast milk which may have a stimulating effect on the breastfed child. Therefore, Ibutran Plus 400 mg/500 mg/25 mg Tablet should be avoided in pregnant or breastfeeding females.

Drug-Drug Interaction: Ibutran Plus 400 mg/500 mg/25 mg Tablet is shown to interact with various drugs. Some of them includes lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, coumadin, jantoven), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), cholesterol reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of Ibutran Plus 400 mg/500 mg/25 mg Tablet and may alter its efficacy.

Drug-Food Interaction: Excessive intake of caffeine containing food or drinks like coffee, tea, chocolate and some fizzy drinks should be avoided while taking Ibutran Plus 400 mg/500 mg/25 mg Tablet. Taking together may lead to drowsiness and dizziness and sleepiness.

Drug-Disease Interaction: Ibutran Plus 400 mg/500 mg/25 mg Tablet should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease, or low blood platelets. Besides this, it should not be given to the children suffering with influenza (flu) or chickenpox. It should also be avoided in case of presence of gastric or duodenal ulcers.

• LITHIUM
• METHOTREXATE
• WARFARIN
• COUMADIN
• JANTOVEN
• METOCLOPRAMIDE
• DOMPERIDONE
• FUROSEMIDE
• PREDNISONE
• CIPROFLOXACIN
• THEOPHYLLINE
• EPHEDRINE
• CHOLESTYRAMINE
• DULOXETINE

• Include more glucosamine, chondroitin sulphate, vitamin D, calcium enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue. 
• Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercise like walking on treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights. 
• In chronic condition of arthritis or joint pain try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimize level of chemical called cytokines, which ramp up inflammation.
• Your sitting posture is important especially when you have pain and inflammation. Try to sit as little as possible, and only for a short duration of time. Long term immobility is harmful in conditions like arthritis. Use back support like a rolled up towel at the back of your spine curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can also use a foot rest if required.

• Ibutran Plus 400 mg/500 mg/25 mg Tablet is commonly prescribed for relieving pain in both acute and chronic conditions and in cases of fever. Do not take the drug beyond its suggested dose and frequency.
• Avoid driving while consuming Ibutran Plus 400 mg/500 mg/25 mg Tablet as it can cause dizziness in some individuals and hamper your focus and reflexes.
• Avoid concomitant consumption of drugs containing the same chemicals as Ibutran Plus 400 mg/500 mg/25 mg Tablet as it can lead to overdosage and unwanted side effects.
• Immediately consult your doctor in case of persistent side effects like stomach pain on consumption of Ibutran Plus 400 mg/500 mg/25 mg Tablet.
• Avoid consuming alcohol while you are on Ibutran Plus 400 mg/500 mg/25 mg Tablet.

Pain can be short-term (acute) or long-term (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone, or organs. While, chronic pain lasts for a longer duration and is caused due to pathologies like nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction, or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, Osteoarthritis is a degenerative disease that results in chronic pain in joints (especially knee) and stiffness, making daily tasks difficult.