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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Hersima 440 mg Injection is used to treat Breast Cancer and Stomach Cancer. Hersima 440 mg Injection contains Trastuzumab, which works by attaching itself to the HER2 proteins so that the cancer cells are no longer stimulated to grow. It also helps the body's immune system to destroy breast cancer cells. It should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy. Advise women not to breastfeed while taking Hersima 440 mg Injection.

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Composition :

TRASTUZUMAB-440MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Hersima 440 mg Injection

Hersima 440 mg Injection is an anti-cancer medicine used in the treatment of HER2-positive Breast cancer and HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Hersima 440 mg Injection contains Trastuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Hersima 440 mg Injection may cause certain side effects such as abdominal pain, chills, diarrhoea, fatigue, nausea, back pain, bone pain, edema, insomnia, fever, dizziness, headache, vomiting, cough, rash, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Hersima 440 mg Injection will be administered by a trained doctor. Hence, do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Hersima 440 mg Injection or its components. Inform your doctor if you have any cardiovascular conditions, lung problems, or liver/kidney disease, as it can cause adverse effects. Hersima 440 mg Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Hersima 440 mg Injection

Treatment of Breast Cancer and Stomach Cancer

Directions for Use

A doctor who is trained or experienced in the administration of chemotherapeutic agents will administer Hersima 440 mg Injection. Do not self-administer.

Medicinal Benefits

Hersima 440 mg Injection contains Trastuzumab, which is used for treating patients with HER2-positive breast cancer and HER2-positive metastatic gastroesophageal adenocarcinoma. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

How Hersima 440 mg Injection Works

Hersima 440 mg Injection contains Trastuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Hersima 440 mg Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Bone pain
  • Headache
  • Fatigue
  • Injection site reactions
  • Pain at the site of injection
  • Dizziness
  • Edema
  • Cough
  • Rash
  • Insomnia

What if I have taken an overdose of Hersima 440 mg Injection

As Hersima 440 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Hersima 440 mg Injection should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any lung problems, cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Hersima 440 mg Injection may cause left ventricular ejection fraction, cardiomyopathy, pulmonary toxicity, exacerbations of chemotherapy-induced neutropenia, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. Hersima 440 mg Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Hersima 440 mg Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

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TrastuzumabIdarubicin
Severe
TrastuzumabBaricitinib
Severe

Drug-Drug Interactions

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TrastuzumabIdarubicin
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
Taking Hersima 440 mg Injection 20 ml with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
Co-administration of Hersima 440 mg Injection 20 ml with Idarubicin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience difficulty breathing, fluid retention, or chest pain, consult a doctor. Do not discontinue any medications without a doctor's advice.
TrastuzumabBaricitinib
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
Coadministration of Hersima 440 mg Injection 20 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Hersima 440 mg Injection 20 ml and Baricitinib, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
TrastuzumabCladribine
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
Combining Hersima 440 mg Injection 20 ml with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Hersima 440 mg Injection 20 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TrastuzumabEtanercept
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
When Etanercept is used with Hersima 440 mg Injection 20 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Hersima 440 mg Injection 20 ml and Etanercept, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TrastuzumabTofacitinib
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
Combining Hersima 440 mg Injection 20 ml with Tofacitinib can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Hersima 440 mg Injection 20 ml and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TrastuzumabClozapine
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
Co-administration of Hersima 440 mg Injection 20 ml and clozapine can increase the risk of toxicity.

How to manage the interaction:
Although taking Hersima 440 mg Injection 20 ml and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not stop using any medications without first talking to your doctor.
TrastuzumabThalidomide
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
Taking thalidomide together with Hersima 440 mg Injection 20 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Hersima 440 mg Injection 20 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
TrastuzumabInfliximab
Severe
How does the drug interact with Hersima 440 mg Injection 20 ml:
Combining Hersima 440 mg Injection 20 ml with Infliximab can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Hersima 440 mg Injection 20 ml with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Hersima 440 mg Injection Substitute

Substitutes safety advice
  • Eleftha 440 Injection 1's

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    50256.57per tablet
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  • Priunta 440 Injection 20 ml

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  • Hervycta 440Mg Inj

    by AYUR

    15498.00per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol as it may cause serious side effects.

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Pregnancy

Unsafe

Hersima 440 mg Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Hersima 440 mg Injection. Use reliable methods of birth control while on treatment with Hersima 440 mg Injection.

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Hersima 440 mg Injection as it can cause serious side effects to the baby.

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Driving

Not applicable

-

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Hersima 440 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Limited data are available on the effect of Hersima 440 mg Injection in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Hersima 440 mg Injection is not recommended for use in children as the safety and efficacy are not established.

FAQs

Hersima 440 mg Injection is used to treat Breast Cancer and Stomach Cancer.
Hersima 440 mg Injection contains Trastuzumab, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.
Inform your doctor whether you have received any other cancer treatment. Hersima 440 mg Injection may cause a decrease in left ventricular ejection fraction, cardiomyopathy, hypersensitivity reactions, pulmonary toxicity, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, lung problems, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Hersima 440 mg Injection.
Consult the doctor immediately, if you experience symptoms of an infection, such as a high temperature, chills, or feeling unwell despite a normal temperature. It could be due to a reduced white blood cell count caused by Hersima 440 mg Injection, increasing your risk of severe infections. Additionally, swollen feet or ankles, stomach pain, or lower back pain may indicate heart problems.
It is recommended to wait at least 6 months after completing Hersima 440 mg Injection therapy before trying to get pregnant. This is because the medication can remain in the body for some time and may potentially affect pregnancy. However, it is essential to consult the doctor for personalized advice and to ensure that it is safe for you to become pregnant after this treatment.
The duration of treatment with Hersima 440 mg Injection will depend on an individual treatment plan, which your doctor will determine based on your specific condition. It may vary based on personal medical conditions and how you respond to the therapy. In some cases, the treatment duration may be shorter or longer. Always attend follow-up appointments as instructed by the doctor for effective treatment.
Fasting is not typically required before administering Hersima 440 mg Injection. However, it is always best to follow the doctor's specific instructions regarding preparations before treatment. If fasting is necessary, your doctor will provide detailed guidance.
Hersima 440 mg Injection should be administered through subcutaneous (SC) or intravenous (IV) routes by the doctor or nurse. Do not self-administer.
Hersima 440 mg Injection should not be administered to patients with HER2-negative cancer cells as it is a monoclonal antibody that specifically targets a protein called human epidermal growth factor receptor 2 (HER2), which is present in high amounts on the surface of specific cancer cells.
The doctor may recommend heart investigations while you are taking Hersima 440 mg Injection as it may potentially affect heart function. It has been associated with heart-related side effects, including a decrease in left ventricular ejection fraction, which could lead to heart failure in some patients. Monitoring heart health helps detect any issues early, ensuring prompt action to manage the risk. Always follow the doctor's recommendations for regular check-ups during treatment.
During treatment with Hersima 440 mg Injection for advanced-stage disease, cardiac monitoring was conducted every 3 to 8 months for up to 2 years. However, the doctor will adjust the frequency of heart investigations based on your specific condition and response to treatment. It's essential to follow their advice for optimal monitoring and early detection of any heart-related issues.
The side effects of Hersima 440 mg Injection include abdominal pain, chills, headache, diarrhoea, fatigue, nausea, back pain, bone pain, oedema, insomnia, fever, dizziness, vomiting, cough, rash, and injection site reactions. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - HER0183

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