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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Hepaglan-25 Injection 5 ml is used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks. It contains Heparin, which works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation. Some people may experience haemorrhage (bleeding), thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme (aminotransferase) levels. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

HEPARIN-25000IU

Manufacturer/Marketer :

Gland Pharma Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Hepaglan-25 Injection 5 ml

Hepaglan-25 Injection 5 ml belongs to a class of drugs called anticoagulants or blood thinners. Hepaglan-25 Injection 5 ml is primarily used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks. Deep vein thrombosis is a medical condition in which blood clots form in deep veins, usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. A stroke is a condition where a blood clot restricts the flow of blood to your brain, causing brain cells to die and possibly resulting in permanent brain damage or death. Transient ischaemic attack (TIA) is a condition also called mini-strokes. These have similar symptoms to a stroke, but the effects usually last less than 24 hours. Heart attack is a condition where a blood clot blocks a blood vessel supplying your heart, starving it of oxygen and causing chest pain and sometimes death.

Blood clots are formed to stop bleeding that occurs due to tissue injury. Though blood clots are useful to stop bleeding, they may be harmful when abnormally formed within blood vessels as they block blood vessels and inhibit blood flow to essential organs such as the brain, heart, or lungs. Hepaglan-25 Injection 5 ml works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation.

Hepaglan-25 Injection 5 ml will be administered by a healthcare professional; do not self-administer. Some people may experience haemorrhage, thrombocytopenia (low platelets), hypersensitivity reactions, and elevations of liver enzyme (aminotransferase) levels. Most of these side effects of Hepaglan-25 Injection 5 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Hepaglan-25 Injection 5 ml or any other medicines, please tell your doctor. It is not known whether Hepaglan-25 Injection 5 ml harms the baby or passes into breast milk in pregnancy and breastfeeding state. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Hepaglan-25 Injection 5 ml. Hepaglan-25 Injection 5 ml is not recommended for children below 2 months of age. If you have diabetes, kidney or liver problems, bleeding problems, or are aged above 60 years, inform your doctor before taking Hepaglan-25 Injection 5 ml.

Uses of Hepaglan-25 Injection 5 ml

Prevention of blood clots.

Directions for Use

Hepaglan-25 Injection 5 ml will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Hepaglan-25 Injection 5 ml is primarily used to prevent and treat blood clots by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot). Hepaglan-25 Injection 5 ml also reduces the risk of blood clots during surgeries (like heart surgery). Hepaglan-25 Injection 5 ml is used as an anticoagulant in blood transfusion and in a dialysis procedure.

How Hepaglan-25 Injection 5 ml Works

Hepaglan-25 Injection 5 ml works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot), preventing blood clot formation.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Hepaglan-25 Injection 5 ml

  • Red itchy patches or lumps at the site of injection
  • Unusual bleeding
  • Skin redness

What if I have taken an overdose of Hepaglan-25 Injection 5 ml

The overdose of Hepaglan-25 Injection 5 ml is unlikely as it is administered by a doctor. Too much heparin may cause bleeding. Therefore, if you suspect any adverse reactions or unusual symptoms or more severe bleeding while on treatment with Hepaglan-25 Injection 5 ml, please inform your doctor immediately.

Drug Warnings

Use Hepaglan-25 Injection 5 ml cautiously in conditions with increased risk of bleeding. Use of name contraindicated in patients with HIT - Heparin-induced thrombosis (the abnormal formation of blood clots inside a blood vessel) and HITT (heparin-induced thrombocytopenia and thrombosis) might occur. Monitoring of blood coagulation tests like platelet count and haematocrit should be done in all patients receiving Hepaglan-25 Injection 5 ml. Patients should inform the doctor that they are receiving Hepaglan-25 Injection 5 ml before any surgery is scheduled.

Drug-Drug Interactions

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HeparinOritavancin
Critical
HeparinMifepristone
Critical

Drug-Drug Interactions

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HeparinOritavancin
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
Using Hepaglan-25 Injection 5 ml with Oritavancin can make Hepaglan-25 Injection 5 ml less effective as a therapy.

How to manage the interaction:
Hepaglan-25 Injection 5 ml is not recommended within 120 hours (5 days) of taking oritavancin. Oritavancin can interfere with certain of the major coagulation tests used to assess Hepaglan-25 Injection 5 ml's effectiveness and safety, it can be taken only if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
HeparinMifepristone
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Mifepristone with Hepaglan-25 Injection 5 ml can increase the risk of negative side effects.

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml with Mifepristone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
HeparinBazedoxifene
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
When Hepaglan-25 Injection 5 ml is taken with bazedoxifene the effects of Hepaglan-25 Injection 5 ml are reduced by bazedoxifene.

How to manage the interaction:
Taking Bazedoxifene with Hepaglan-25 Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
HeparinTiclopidine
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Ticlopidine with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Ticlopidine with Hepaglan-25 Injection 5 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
HeparinTenecteplase
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Tenecteplase with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml with Tenecteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
HeparinAlteplase
Critical
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Alteplase with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml with Alteplase is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
HeparinRivaroxaban
Severe
How does the drug interact with Hepaglan-25 Injection 5 ml:
Co-administration of Hepaglan-25 Injection 5 ml and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Hepaglan-25 Injection 5 ml and Rivaroxaban can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
HeparinIbrutinib
Severe
How does the drug interact with Hepaglan-25 Injection 5 ml:
Co-administration of Ibrutinib with Hepaglan-25 Injection 5 ml can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Ibrutinib and Hepaglan-25 Injection 5 ml, but it can be taken if prescribed by a doctor. However, consult a doctor, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
HeparinDicoumarol
Severe
How does the drug interact with Hepaglan-25 Injection 5 ml:
Coadministration of Hepaglan-25 Injection 5 ml and dicumarol may increase the risk of bleeding.

How to manage the interaction:
Although taking Hepaglan-25 Injection 5 ml and Dicoumarol together can cause an interaction, it can be taken if a doctor has suggested it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
HeparinBivalirudin
Severe
How does the drug interact with Hepaglan-25 Injection 5 ml:
Taking Bivalirudin with Hepaglan-25 Injection 5 ml may increase the risk of bleeding.

How to manage the interaction:
Although taking Bivalirudin and Hepaglan-25 Injection 5 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you have unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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HEPARIN-25000IUHerbal products/medicines
Moderate

Drug-Food Interactions

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HEPARIN-25000IUHerbal products/medicines
Moderate
Common Foods to Avoid:
Garlic Pill

How to manage the interaction:
Taking Hepaglan-25 Injection 5 ml along with herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba can lead to an increased risk of bleeding Avoid taking herbs and supplements such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba while taking Hepaglan-25 Injection 5 ml.

Habit Forming

No

Therapeutic Class

ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS

Hepaglan-25 Injection 5 ml Substitute

Substitutes safety advice
  • Caprin 25000IU Injection 5 ml

    59.04per tablet
  • Beparine 25000IU Injection 1's

    302.00per tablet
  • Stanhep-25000IU Injection 5 ml

    61.56per tablet
  • Reniparin 25000 Iu Inj

    by AYUR

    305.10per tablet
  • Rinhepa 25K/5Ml Inj

    by AYUR

    58.96per tablet
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Alcohol

Caution

You are recommended to avoid consumption of alcohol with Hepaglan-25 Injection 5 ml as it may cause severe bleeding in the stomach and harmful side effects to the liver.

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Pregnancy

Caution

Hepaglan-25 Injection 5 ml is a Category C pregnancy drug and should be given to pregnant women only if clearly needed and has more benefits than risks. Preservative-free forms are preferred in pregnant women as preservatives such as benzyl alcohol may cross the placenta.

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Breast Feeding

Caution

Hepaglan-25 Injection 5 ml should be given to breastfeeding mothers only if clearly needed and has more benefits than risks.

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Driving

Safe if prescribed

Hepaglan-25 Injection 5 ml usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Hepaglan-25 Injection 5 ml should be given with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Hepaglan-25 Injection 5 ml should be given with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Hepaglan-25 Injection 5 ml is not recommended for children below 2 months.

FAQs

Hepaglan-25 Injection 5 ml is used to prevent and treat deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), stroke, Transient ischaemic attack (TIA), and heart attacks.
Hepaglan-25 Injection 5 ml works by inhibiting the production of fibrin (a protein that binds platelets together and forms a clot). Thereby, preventing blood clot formation.
No, you are not recommended to take ibuprofen with Hepaglan-25 Injection 5 ml as co-administration of these two medicines may increase the risk of bleeding more easily. However, please consult a doctor before taking other medicines with Hepaglan-25 Injection 5 ml.
Yes, Hepaglan-25 Injection 5 ml may increase potassium levels in the blood (hyperkalaemia), especially when given for a long period. Therefore, it is advised to inform your doctor if you are taking any medicines that increase potassium levels in the blood.
Yes, Hepaglan-25 Injection 5 ml may cause bleeding. If you notice purple spots on the skin or unusual bruising, blood in urine, black tarry stools, unusual bleeding from gums or nose, please inform your doctor immediately as these are signs of bleeding more easily.
Yes, Hepaglan-25 Injection 5 ml may cause allergic reactions such as fever, chills, difficulty in breathing, wheezing, blue shade to the lips, swelling of lips, and eyes. It is not necessary for everyone taking Hepaglan-25 Injection 5 ml to experience an allergic reaction. However, if you notice any of these signs, please inform your doctor immediately.

Country of origin

INDIA

Manufacturer/Marketer address

Gland Pharma Limited, 6-3-865/1/2, Greenland Apartments, Ameerpet, Hyderabad - 500016, India
Other Info - HEP0258

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