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GZM 80mg/500mg Tablet

GZM 80mg/500mg Tablet

Prescription drug
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Consult Doctor

Manufacturer/Marketer

Anant Pharmaceuticals Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About GZM 80mg/500mg Tablet

GZM 80mg/500mg Tablet belongs to a class of medicine known as an anti-diabetic. It is primarily used to treat Type 2 diabetes. Type 2 diabetes is a chronic or lifelong condition affecting how your body processes glucose. People with type 2 diabetes either do not produce enough insulin, or if at all the insulin is produced, it is unable to perform its function in the body (insulin resistance). Due to this, the blood glucose level increases and symptoms such as frequent urination, increased thirst and increased hunger start. It can lead to serious complications like skin infection, eye problems (retinopathy), nerve damage (neuropathy), diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke.

GZM 80mg/500mg Tablet is a combination of two anti-diabetic drugs: Gliclazide and Metformin. Gliclazide is a 'sulfonylurea' which acts by increasing the amount of insulin released by the pancreas. On the other hand, Metformin, which is a 'biguanide', works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. In a nutshell, the two medicines prevent blood glucose levels from rising to very high levels, thus keeping your Diabetes under control. GZM 80mg/500mg Tablet act together to keep your blood sugar levels under check. The strict control of blood sugars is especially important to mention the many disabling side effects of Diabetes. GZM 80mg/500mg Tablet shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, a healthy diet etc. 

GZM 80mg/500mg Tablet should be taken with food to avoid an upset stomach. GZM 80mg/500mg Tablet should be taken at the same time of the day each time for best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. A common side effect of GZM 80mg/500mg Tablet is hypoglycaemia (low blood glucose levels) characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycaemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

You should not take the GZM 80mg/500mg Tablet if you have diabetic ketoacidosis (excess acids in your blood). GZM 80mg/500mg Tablet should not be stopped even if you feel better without consulting your doctor as sugar levels change. If you stop taking GZM 80mg/500mg Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). GZM 80mg/500mg Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Tell your doctor before prescribing the GZM 80mg/500mg Tablet if you are a pregnant woman or nursing mother.

Uses of GZM 80mg/500mg Tablet

Treatment of Type 2 Diabetes Mellitus

Medicinal Benefits

GZM 80mg/500mg Tablet plays a vital role in decreasing the blood sugar level in the body as metformin lowers glucose production in the liver, whereas the other increases the amount of insulin released by the pancreas. GZM 80mg/500mg Tablet also helps to prevent serious complications of diabetes such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), loss of sensation in your hands and feet (diabetic neuropathy) or even loss of the foot. GZM 80mg/500mg Tablet also helps to reduce your chance of having a heart attack or stroke. Being a combination of two drugs, it reduces the need to take multiple pills and hence makes it easier to remember to take the drugs.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of GZM 80mg/500mg Tablet

  • Hypoglycaemia (low blood glucose level)

  • Dizziness

  • Sweating

  • Palpitations

  • Hunger pangs

  • Dry mouth

  • Dry skin

  • Taste change

  • Nausea

  • Diarrhoea

  • Stomach pain

  • Headache

Drug Warnings

Some diabetic patients taking GZM 80mg/500mg Tablet may develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid is accumulated in the blood. So, your liver and kidney's proper functioning is required to eliminate excess lactic acid from the blood. You should not take GZM 80mg/500mg Tablet if you have kidney disease, as measured by a blood test. GZM 80mg/500mg Tablet may lower vitamin B12 levels, so try to have blood tests annual blood and vitamin. GZM 80mg/500mg Tablet, when used with or without insulin, tends to lower the blood sugar level extremely. So, the doctor may reduce the dose of insulin. GZM 80mg/500mg Tablet may lower your thyroid-stimulating hormone (TSH), so an annual check-up of TSH is suggested.

Drug Interactions

Drug-Drug Interactions: GZM 80mg/500mg Tablet may interact with insulin, high blood pressure-lowering pills (e.g. hydrochlorothiazide, amlodipine), water pills/diuretics (e.g. furosemide), heart failure-related medicines (e.g. digoxin), anti-hypertensive (e.g. metoprolol), steroids (e.g. prednisolone), thyroid hormones etc. So, tell your doctor if you are using these drugs before taking the GZM 80mg/500mg Tablet.

Drug-Food Interactions: Taking GZM 80mg/500mg Tablet with alcoholic beverages may increase the risk of a rare but serious and potentially life-threatening condition known as lactic acidosis (build-up of lactic acid in the blood) and hypoglycaemia.

Drug-Disease Interactions: GZM 80mg/500mg Tablet should be avoided in patients with vitamin B12 deficiency, kidney problems, liver problems, cardiovascular disease (heart-related issues), and low blood sugar level (hypoglycaemia) as it may worsen the condition.

Drug-Drug Interactions Checker List

  • INSULIN
  • HYDROCHLOROTHIAZIDE
  • AMLODIPINE
  • FUROSEMIDE
  • DIGOXIN
  • METOPROLOL
  • PREDNISOLONE

Habit Forming

No

Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.

  • Eat at regular intervals. Do not take the long gap between a meal or snack.

  • Monitor your blood sugar level regularly, especially when there are a lot of fluctuations.

  • Invest at least 150 minutes of moderate-intensity physical activity and 15 minutes of high-intensity exercise weekly.

  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).

  • Replace refined carbohydrates-containing foods with whole grain foods and increase intake of fruits, veggies, and other fibre-enriched foods.

  • Reduce saturated fat intake (or hidden fats) in food like chips, crisps, pastries, biscuits and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you may use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.

  • Do not take stress as it may elevate your blood sugar level. You may adopt stress management techniques like mindfulness, yoga or meditation to control pressure related to blood sugar changes.

  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk and cheese etc.).

  • Keep your blood pressure as normal (120/80) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Special Advise

  • Keep taking the drug even if you think your blood sugar levels are under control. If you miss a dose, do not take a larger dose; consult your treating physician for advice. 

  • Take short, frequent meals, and avoid prolonged fasting when taking this drug. Beware of hypoglycaemia symptoms, including sweating, dizziness, palpitations, shivering, intense thirst, dry mouth, dry skin, frequent urination etc. Whenever you experience the symptoms mentioned above, immediately consume 5-6 candies or 3 glucose biscuits or 3 teaspoons of honey/sugar and get in touch with your physician. Make sure to carry these with you at all times, especially for long travels. 

  • Before the doctor prescribes this medicine, it is always better that your physician knows about any underlying conditions like kidney or liver disease, prior heart attack, alcohol intake, etc..

  • Avoid drinking alcohol while on this drug as it increases the risk of hypoglycaemia (decrease in blood sugar which might be fatal in some cases) and lactic acidosis (when the lactic acid increases in the body, which impacts the functioning of various organs in the body).

  • Try to quit smoking and reduce your intake of carbohydrate-rich food like potatoes, rice, mangoes, bread, sugar etc.

  • Remember, lifestyle modifications are the most important step in controlling blood sugar levels.

Disease/Condition Glossary

Diabetes Mellitus type 2 is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, excessive insulin is produced but it fails to act on the organs of the body. Symptoms of type 2 diabetes include feeling exhausted all time, feeling thirsty, having blurry vision, and urge to urinate (pee) more often. Complications of type 2 diabetes include skin infection, eye problems (retinopathy), nerve damage (neuropathy), delayed wound healing, diabetic foot (foot ulcer), kidney disease (nephropathy), high blood pressure, and even stroke. Both low and high blood sugar levels can be dangerous and should be treated as soon as possible. Your H1bA1C below 5.7% is normal, 5.7-6.4% confirms the prediabetes stage, and 6.5% or greater states diabetes condition. 

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Alcohol

Unsafe

You are recommended not to consume alcohol along with GZM 80mg/500mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking GZM 80mg/500mg Tablet; your doctor will decide whether GZM 80mg/500mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

GZM 80mg/500mg Tablet may cause hypoglycaemia (low blood sugar levels), whose symptoms include unusual sleepiness, shivering, palpitations, sweating etc. This may affect your ability to drive. Use caution while driving or doing anything that requires concentration.

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Liver

Caution

Tell your doctor before prescribing the GZM 80mg/500mg Tablet if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending upon your current liver conditions.

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Kidney

Caution

Tell your doctor before receiving the GZM 80mg/500mg Tablet if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending upon your current liver conditions.

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Children

Unsafe

The safety and efficacy of GZM 80mg/500mg Tablet in children have not been established. GZM 80mg/500mg Tablet is not recommended in children.

Country of origin

India
Other Info - GZMM356

Author Details

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FAQs

GZM 80mg/500mg Tablet is used to treat Type 2 diabetes.
GZM 80mg/500mg Tablet is a combination of two anti-diabetic drugs: Gliclazide and Metformin. Gliclazide is a 'sulfonylurea' which acts by increasing the amount of insulin released by the pancreas. On the other hand, Metformin, which is a 'biguanide', works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. In a nutshell, the two medicines prevent blood glucose levels from rising to very high levels, thus keeping your Diabetes under control.
Hypoglycemia refers to low blood sugar levels and it is one of the side effects of GZM 80mg/500mg Tablet. Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. It is important to regularly monitor blood sugar levels.
No, GZM 80mg/500mg Tablet should not be used with other anti-diabetic medications as it may cause hypoglycemia (lowering of blood sugar level).
If you feel thirsty after taking GZM 80mg/500mg Tablet, it may be because of dehydration as GZM 80mg/500mg Tablet can lead to loss of fluids. Increase intake of fluids, if even then you feel thirsty please consult your doctor.
Yes, long-term usage of GZM 80mg/500mg Tablet can cause vitamin B12 deficiency as it interferes with the absorption of vitamin B12 in the stomach. The symptoms of vitamin B12 deficiency include fatigue, nerve problems, tingling sensation and numbness in hands and feet, weakness, urinary problems, affect mental status, and difficulty in maintaining balance. These symptoms can be managed by taking Vitamin B12 supplements as advised by your doctor.
If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing, and frequent infections, contact doctor as it can be a condition of type 2 diabetes.
In case you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.
Type-2 diabetes generally does not affect healthy children and teens, but it may affect children who are obese, which is also known as Childhood Obesity.
Include a diet rich in fruits, vegetables and whole grains like brown rice, whole wheat, oats, barley, and quinoa. Non-fat or low-fat dairy and proteins like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey can also be included.
Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.
Hypoglycaemia (low blood sugar) may occur because you inject too much insulin, miss or delay meals, do not eat enough, eat food containing less carbohydrate than normal, drink alcohol, lose carbohydrates due to vomiting or diarrhoea, do more exercise than usual or a different type of physical activity, are recovering from an injury, illness, operation or stress, or are taking/have stopped taking other medicines.
GZM 80mg/500mg Tablet is an anti-diabetic medicine used to treat type-2 diabetes.
Possible side effects of GZM 80mg/500mg Tablet are low blood sugar, taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms. Consult the doctor if the side effects persist or worsen.
GZM 80mg/500mg Tablet can cause lactic acidosis, a rare, but serious, metabolic complication. Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and severe tiredness.
GZM 80mg/500mg Tablet should not be taken by people who are allergic to any of its components, people having severe kidney disease or diabetic ketoacidosis.
No, it is not safe to drink alcohol while taking GZM 80mg/500mg Tablet as it might cause low blood sugar and unpleasant side effects.
GZM 80mg/500mg Tablet should be taken during pregnancy and breastfeeding only if prescribed by the doctor.
GZM 80mg/500mg Tablet may not be recommended for children as the safety and efficacy have not been established. Please consult the doctor.
Overdose may cause hypoglycaemia (low blood sugar). Seek medical attention if you have overdosed on GZM 80mg/500mg Tablet.

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