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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:45 PM IST
Guficol Plus 1 miu Injection is used to treat bacterial infections. It contains Colistimethate Sodium.  It effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, it destroys the bacteria and successfully treats the infection. Common side effects of Guficol Plus 1 miu Injection may include injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness.
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Prescription drug

Whats That

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Synonym :

COLISTIN

Manufacturer/Marketer :

Gufic Bioscience Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Guficol Plus 1 miu Injection

Guficol Plus 1 miu Injection belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Guficol Plus 1 miu Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Guficol Plus 1 miu Injection destroys the bacteria and successfully treats the infection.

Guficol Plus 1 miu Injection will be administered by a qualified healthcare professional. Sometimes, you may experience common side effects like injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.

Before receiving Guficol Plus 1 miu Injection, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Guficol Plus 1 miu Injection can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.

Uses of Guficol Plus 1 miu Injection

Treatment of Bacterial infections

Directions for Use

Guficol Plus 1 miu Injection will be administered by a qualified healthcare professional. Do not self-administer.

Medicinal Benefits

Guficol Plus 1 miu Injection contains Colistimethate Sodium. Colistimethate Sodium, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Guficol Plus 1 miu Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.

How Guficol Plus 1 miu Injection Works

Guficol Plus 1 miu Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Guficol Plus 1 miu Injection destroys the bacteria and successfully treats the infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Guficol Plus 1 miu Injection

  • Superinfection (reinfection)
  • Renal damage
  • Visual disturbances
  • GI disturbances
  • Dizziness
  • Nausea
  • Vomiting
  • Confusion
  • Peripheral neuropathy
  • Respiratory insufficiency
  • Muscle weakness

What if I have taken an overdose of Guficol Plus 1 miu Injection

As Guficol Plus 1 miu Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Guficol Plus 1 miu Injection may cause paraesthesia, lethargy, confusion, ataxia, dizziness, apnoea, possible respiratory arrest, and acute renal failure.

Drug Warnings

If you are allergic to Guficol Plus 1 miu Injection, please inform your physician. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Guficol Plus 1 miu Injection. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.

Drug-Drug Interactions

verifiedApollotooltip
ColistinBCG vaccine
Critical
ColistinPancuronium
Severe

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Diet & Lifestyle Advise

  • After taking the full course of Guficol Plus 1 miu Injection, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking many calcium-enriched foods and drinks as it might affect the working of Guficol Plus 1 miu Injection.
  • Avoid intake of alcoholic beverages with Guficol Plus 1 miu Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Guficol Plus 1 miu Injection in fighting off infections.

Habit Forming

No

Therapeutic Class

ANTI- BACTERIALS

Guficol Plus 1 miu Injection Substitute

Substitutes safety advice
  • Xylistin 1MIU Injection 1's

    1605.60per tablet
  • Zizant 1 MIU Injection 1's

    1993.50per tablet
  • Kabimethate 1 miu Injection 1's

    1410.30per tablet
  • Coligyl-1 MIU Injection 1's

    1540.00per tablet
  • Elistin 1MIU Injection 1's

    800.00per tablet
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Alcohol

Caution

Limit alcohol consumption while on treatment with this medicine as it may worsen drowsiness, dizziness or sleepiness.

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Pregnancy

Caution

Guficol Plus 1 miu Injection should not be used in pregnancy unless necessary. Hence, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Guficol Plus 1 miu Injection.

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Breast Feeding

Caution

Guficol Plus 1 miu Injection should not be used in nursing mothers unless necessary. So, inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Guficol Plus 1 miu Injection.

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Driving

Caution

You may have side effects like visual disturbances and dizziness after taking Guficol Plus 1 miu Injection that may make you unfit to drive or operate machinery. Hence, do not drive or operate machinery until you are feeling well.

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Liver

Safe if prescribed

Inform your doctor before receiving Guficol Plus 1 miu Injection if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Caution should be exercised while using Guficol Plus 1 miu Injection in patients with severe kidney disease. Inform your doctor before receiving Guficol Plus 1 miu Injection if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

FAQs

Guficol Plus 1 miu Injection is used to treat Bacterial infections.
Guficol Plus 1 miu Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Guficol Plus 1 miu Injection destroys the bacteria and successfully treats the infection.
Guficol Plus 1 miu Injection is contraindicated in people with Hypersensitivity to any component in Guficol Plus 1 miu Injection. Besides this, it is also contraindicated to use in people with myasthenia gravis (muscle disorder).
Guficol Plus 1 miu Injection contains Colistimethate Sodium. It is an antibiotic medication used when other drugs or therapy are ineffective. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Guficol Plus 1 miu Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.
Do not use anti diarrhoeal until the doctor has prescribed you. You can drink plenty of fluids (electrolytes) to avoid dehydration. Besides this, you can also take prebiotics or probiotics to manage diarrhoea as it may help increase the number of good bacteria in the intestine, which aids indigestion.
After taking an antibiotic, you may need to wait up to three hours to eat or drink dairy products, including milk and butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work to dampen the effect of antibiotics.
Before taking Guficol Plus 1 miu Injection, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.
Guficol Plus 1 miu Injection is prescribed during pregnancy only if your doctor thinks that the benefits are greater than the potential risks. The safety of Guficol Plus 1 miu Injection during pregnancy has not been fully established. Therefore, consult your doctor before taking Guficol Plus 1 miu Injection if you are pregnant.
Guficol Plus 1 miu Injection is safe when used as per the dose and duration advised by a doctor.
Guficol Plus 1 miu Injection is effective when taken as per the doses prescribed by your doctor. Guficol Plus 1 miu Injection should be administered under medical supervision for optimal results.
If you forget to take a dose of Guficol Plus 1 miu Injection consult your healthcare provider for advice. Your doctor will guide you on the appropriate steps, but do not administer an extra dose to make up for the missed one.
Guficol Plus 1 miu Injection causes side effects such as visual disturbances, dizziness, nausea, vomiting, confusion, muscle weakness, respiratory insufficiency, and kidney damage. Therefore, please contact a doctor if any of these side effects persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

Shantisadan, Mirzapur Road, Ahmedabad -380001
Other Info - GUF0007

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