Can I take Guficol 4.5miu Injection with gentamicin?

You are not recommended to take Guficol 4.5miu Injection with gentamicin as co-administration of these two medicines may increase the risk of severe adverse effects such as kidney problems, hearing loss or respiratory depression especially in elderly people and in those who have preexisting kidney disease or who are dehydrated. However, please consult your doctor before taking Guficol 4.5miu Injection with other medicines.

Does Guficol 4.5miu Injection cause dizziness?

Guficol 4.5miu Injection may cause dizziness as a common side effect. Avoid driving if you feel dizzy after taking Guficol 4.5miu Injection. However, if the condition persists or worsens, please consult a doctor.

Is Guficol 4.5miu Injection safe for people on dialysis?

Guficol 4.5miu Injection should be used with caution in patients receiving dialysis (the process of filtration and purification of blood using a machine). Therefore, if you are receiving dialysis, please inform your doctor before taking Guficol 4.5miu Injection so that the dose may be adjusted accordingly.

Can I take Guficol 4.5miu Injection if I have kidney disease?

You are recommended to take Guficol 4.5miu Injection with extreme caution if you have kidney disease as it may worsen the condition. Regular monitoring of kidney functioning is recommended while taking Guficol 4.5miu Injection. Therefore, inform your doctor if you have any kidney problems before taking Guficol 4.5miu Injection.

What should I tell my doctor before taking Guficol 4.5miu Injection?

Before taking Guficol 4.5miu Injection, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.

How is Guficol 4.5miu Injection administered?

Guficol 4.5miu Injection is given by a healthcare professional as an infusion over 30–60 minutes or as a rapid injection within 5 minutes into a vein. Do not self-administer.

Who should not use Guficol 4.5miu Injection?

Do not use Guficol 4.5miu Injection if you are allergic to its active substances or any other polymyxins (group of antibiotics to treat bacterial infection). If you are unsure, consult your doctor before receiving Guficol 4.5miu Injection.

Can I take Guficol 4.5miu Injection in pregnancy?

Guficol 4.5miu Injection is prescribed during pregnancy only if your doctor thinks that the benefits are greater than the potential risks. The safety of Guficol 4.5miu Injection during pregnancy has not been fully established. Therefore, consult your doctor before taking Guficol 4.5miu Injection if you are pregnant.

Is Guficol 4.5miu Injection safe?

Guficol 4.5miu Injection is safe when used as per the dose and duration advised by a doctor.

What are the side effects of Guficol 4.5miu Injection?

Guficol 4.5miu Injection causes side effects such as dizziness, stomach upset, tingling, and difficulty in breathing. However, these do not require any medical treatment and gradually reduce over time. Contact a doctor if these side effects persist for longer durations.

Guficol 4.5miu Injection

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Guficol 4.5miu Injection is used to treat bacterial infections. It contains Colistimethate which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as stomach upset, itching, rash, and fever. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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About Guficol 4.5miu Injection

Guficol 4.5miu Injection belongs to a class of drugs called antibiotics used in the treatment of severe bacterial infections. Bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. It can infect any part of the body and multiply very quickly. Guficol 4.5miu Injection does not work against infections caused by a virus.

Guficol 4.5miu Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damaging bacterial cell membranes and kills bacteria.

Take Guficol 4.5miu Injection as prescribed by your doctor. You are advised to take Guficol 4.5miu Injection for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience dizziness, stomach upset, tingling, or difficulty in breathing. Most of these side effects of Guficol 4.5miu Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Guficol 4.5miu Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Guficol 4.5miu Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Guficol 4.5miu Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Guficol 4.5miu Injection may cause confusion, vision problems, or dizziness. If you are on dialysis, inform your doctor before taking Guficol 4.5miu Injection so that the dose may be reduced accordingly.

Uses of Guficol 4.5miu Injection

Treatment of Several bacterial infections

Directions for Use

Guficol 4.5miu Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Guficol 4.5miu Injection contains Colistimethate, a narrow-spectrum antibiotic that is active against gram-negative bacteria. Guficol 4.5miu Injection binds to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria. Guficol 4.5miu Injection is used when other antibiotics are not suitable.

How Guficol 4.5miu Injection Works

Guficol 4.5miu Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damaging bacterial cell membranes and kills bacteria.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Guficol 4.5miu Injection

Dizziness
Stomach upset
Tingling
Difficulty in breathing

What if I have taken an overdose of Guficol 4.5miu Injection

Use Guficol 4.5miu Injection only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include dizziness, confusion, loss of balance/coordination, rapid eye movement, severe numbness/tingling, weak/shallow breathing, problems with speech, and loss of consciousness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Guficol 4.5miu Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Guficol 4.5miu Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Guficol 4.5miu Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Guficol 4.5miu Injection may cause confusion, vision problems, or dizziness. If you are on dialysis, inform your doctor before taking Guficol 4.5miu Injection so that the dose may be reduced accordingly. Inform your anesthetist that you are taking Guficol 4.5miu Injection as it may increase the effects of muscle relaxants used in general anesthesia. You are recommended to complete the full course of Guficol 4.5miu Injection as prescribed by your doctor for effective results.

Drug-Drug Interactions

ColistinBCG vaccine

Critical

ColistinPancuronium

Severe

Drug-Drug Interactions

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ColistinBCG vaccine

Critical

How does the drug interact with Guficol 4.5miu Injection:
Coadministration of Guficol 4.5miu Injection along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Guficol 4.5miu Injection with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.

ColistinPancuronium

Severe

How does the drug interact with Guficol 4.5miu Injection:
Using Pancuronium with Guficol 4.5miu Injection can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Pancuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.

ColistinIohexol

Severe

How does the drug interact with Guficol 4.5miu Injection:
Combining Guficol 4.5miu Injection with Iohexol can increase the effect or side effects of Iohexol.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Iohexol, you can take these medicines if prescribed by your doctor. However, if you experience vomiting, loss of appetite, irregular urination, swelling, shortness of breath, muscle cramps, or weakness, consult a doctor. Do not stop using any medications without a doctor's advice.

ColistinEverolimus

Severe

How does the drug interact with Guficol 4.5miu Injection:
Coadministration of Guficol 4.5miu Injection with Everolimus can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Everolimus, it can be taken if prescribed by a doctor. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.

ColistinTenofovir alafenamide

Severe

How does the drug interact with Guficol 4.5miu Injection:
Combining Guficol 4.5miu Injection with Tenofovir alafenamide may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Tenofovir alafenamide, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience an upset stomach, rash, dizziness, or fever. Do not stop using any medications without a doctor's advice.

ColistinStreptomycin

Severe

How does the drug interact with Guficol 4.5miu Injection:
Coadministration of Streptomycin with Guficol 4.5miu Injection may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Streptomycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, muscle pain, dizziness, or palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.

ColistinVecuronium

Severe

How does the drug interact with Guficol 4.5miu Injection:
Using Vecuronium with Guficol 4.5miu Injection can make Vecuronium more effective in therapy.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Vecuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.

ColistinAdefovir dipivoxil

Severe

How does the drug interact with Guficol 4.5miu Injection:
Combining Guficol 4.5miu Injection with Adefovir dipivoxil may decrease Guficol 4.5miu Injection's excretion rate, which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Adefovir dipivoxil, you can take these medicines together if prescribed by your doctor. However, if you experience any irregular urination, swelling, shortness of breath, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.

ColistinCisatracurium

Severe

How does the drug interact with Guficol 4.5miu Injection:
Coadministration of Cisatracurium with Guficol 4.5miu Injection may increase the risk of side effects of Cisatracurium.

How to manage the interaction:
Although there is a possible interaction of Cisatracurium with Guficol 4.5miu Injection, it can be taken if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, Slurred speech, Vertigo, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.

ColistinKanamycin

Severe

How does the drug interact with Guficol 4.5miu Injection:
Coadministration of Guficol 4.5miu Injection with Kanamycin can increase the level and risk of Guficol 4.5miu Injection side effects.

How to manage the interaction:
Although there is a possible interaction between Guficol 4.5miu Injection and Kanamycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, swelling, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Take probiotics after completing the full course of Guficol 4.5miu Injection to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like cheese, yogurt, kombucha, sauerkraut, and kimchi can restore the good bacteria of the intestine.
Include fiber-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains such as whole-grain bread and brown rice should be included in your diet.
Make sure you drink plenty of water or other fluids every day while you are taking Guficol 4.5miu Injection.
Avoid alcohol consumption as it may increase adverse effects.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Guficol 4.5miu Injection Substitute

Colina 4.5miu Injection
by AYUR
₹3681.80per tablet
Promistin Forte 4.5million Iu Injection
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Hicoly 4.5MIU Injection 1's
₹2356.20per tablet

Alcohol

Caution

Interaction of Guficol 4.5miu Injection with alcohol is unknown. Please consult a doctor before consuming alcohol while using Guficol 4.5miu Injection.

Pregnancy

Caution

Guficol 4.5miu Injection is a category C pregnancy drug and is given to pregnant women only if it is essential. Please consult a doctor if you are pregnant or planning for pregnancy.

Breast Feeding

Caution

Guficol 4.5miu Injection may be excreted in human milk in small amounts. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

Driving

Caution

Guficol 4.5miu Injection may cause confusion, vision problems or dizziness. Therefore, avoid driving if you experience any of these symptoms after taking Guficol 4.5miu Injection.

Liver

Caution

Take Guficol 4.5miu Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

Kidney

Caution

Take Guficol 4.5miu Injection with caution, especially if you have a history of Kidney diseases/conditions as Guficol 4.5miu Injection may affect kidney function. The dose may be adjusted by your doctor as required.

Children

Caution

Guficol 4.5miu Injection should be used with caution in children and in doses as prescribed by a doctor. Special care should be taken in new-born and premature babies as kidneys are not developed fully.

FAQs

Country of origin

India

Manufacturer/Marketer address

37,1st Floor, Kamala Bhavan II, Swami Nityanand Road, Andheri (East), Mumbai - 400 069. (INDIA)

Other Info - GUF0002

Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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