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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Last Updated Dec 7, 2024 | 2:25 PM IST
Gamaglobin 16.5% Injection is used to treat immunoglobulin (antibody) deficiency and certain inflammatory disorders. It contains Human normal immunoglobulin which helps the body fight against infections and works the same way as natural immunoglobulins. In some cases, this medicine may cause side effects such as injection site reactions, headache, fever, flu-like symptoms, and throat tightness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer :

Zydus Cadila

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Gamaglobin 16.5% Injection

Gamaglobin 16.5% Injection belongs to the class of medications called ‘immunising agents’ used to treat immunoglobulin (antibody) deficiency and certain inflammatory disorders. It is used to treat immunoglobulin deficiency in people with primary immunodeficiency or PID (present from birth) and secondary immunodeficiency or SID (developed in the later stages of life). Gamaglobin 16.5% Injection is also used to treat inflammatory disorders such as primary immune thrombocytopenia (reduced number of platelets), Guillain-Barre syndrome (short-term inflammation of the peripheral nerves causing weakness of legs and upper limbs), Kawasaki disease (inflammation of blood vessels in children), chronic inflammatory demyelinating polyneuropathy or CIDP (long-term inflammation of peripheral nerves), and multifocal motor neuropathy (progressive disease leading to weakness of arms and legs).

Gamaglobin 16.5% Injection contains ‘Human normal immunoglobulin’, which replaces the deficient antibodies necessary to act against infections and inflammation. It works exactly as the immunoglobulins present in the body. Immunoglobulins are an essential part of the immune system, which recognises the antigens or foreign elements in the body and aids in their destruction. It also helps to reduce inflammation by improving immunity.

Gamaglobin 16.5% Injection will be administered by a trained healthcare professional; hence do not self-administer. This may cause side effects such as swelling or hardening at the injection site and headache, pain in the face, back, arms, legs, joints, or neck, fever, flu-like illness (runny nose and sore throat), blisters in the mouth, and throat, and throat tightness. These side effects are usually mild and temporary. However, if any of the side effects persist or get worse, inform your doctor immediately.

It is not recommended to take Gamaglobin 16.5% Injection if you are allergic to any of its contents or have blood clotting disorders. Before taking Gamaglobin 16.5% Injection, inform your doctor if you have had any vaccinations recently or have already had this product recently. Gamaglobin 16.5% Injection should be used with caution in people with immunoglobulin A (IgA) deficiency (IgA is a type of antibody that protects against infections). Gamaglobin 16.5% Injection is probably safe when given to children, pregnant women, and breastfeeding mothers. Gamaglobin 16.5% Injection should be used with caution in elderly people. Gamaglobin 16.5% Injection may not interact with alcohol. Gamaglobin 16.5% Injection may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of Gamaglobin 16.5% Injection

Treatment of Immunoglobulin deficiency and inflammatory disorders such as primary immune thrombocytopenia, Guillain-Barre syndrome, Kawasaki disease, chronic inflammatory demyelinating polyneuropathy, and multifocal motor neuropathy.

Medicinal Benefits

Gamaglobin 16.5% Injection acts by replacing the deficient antibodies that are necessary to act against infections and inflammation. It works exactly as the immunoglobulins present in the body. Immunoglobulins are an important part of the immune system, which recognizes the antigens or foreign elements in the body and causes their destruction. It is used to treat immunoglobulin deficiency in people with primary immunodeficiency or PID (present from birth) and secondary immunodeficiency or SID (developed in the later stages of life). Gamaglobin 16.5% Injection is also used to treat inflammatory disorders such as primary immune thrombocytopenia (reduced number of platelets), Guillain-Barre syndrome (short-term inflammation of the peripheral nerves causing weakness of legs and upper limbs), Kawasaki disease (inflammation of blood vessels in children), chronic inflammatory demyelinating polyneuropathy or CIDP (long-term inflammation of peripheral nerves), and multifocal motor neuropathy (progressive disease leading to weakness of arms and legs).

Side Effects of Gamaglobin 16.5% Injection

  • Swelling or hardening at the injection site
  • Headache
  • Pain in the face, back, arms, legs, joints, or neck
  • Fever
  • Flu-like illness (runny nose and sore throat)
  • Blisters in the mouth and throat
  • Throat tightness

Directions for Use

A trained healthcare professional will administer Gamaglobin 16.5% Injection, so do not self-administer. The injection is given subcutaneously (under the skin), whereas infusion is given via intravenous (into the vein) route.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Gamaglobin 16.5% Injection should be used with caution in people with immunoglobulin A (IgA) deficiency (IgA is a type of antibody that protects against infections) as there is an increased risk of allergic reactions. Gamaglobin 16.5% Injection may cause a sudden fall in blood pressure with an allergic reaction, including shock, even in patients who have tolerated previous treatment with this medicine. So, it is advised to monitor patients during infusion and at least 20 min after the infusion. If you develop a severe headache, drowsiness, fever, neck stiffness, sensitivity to light, nausea, and vomiting after Gamaglobin 16.5% Injection, inform your doctor immediately. It may signify aseptic meningitis syndrome (severe inflammation of the brain's linings). Gamaglobin 16.5% Injection should be used with caution in people with obesity or overweight, diabetes, high blood pressure (hypertension), hypovolemia (low blood volume), and blood clotting disorders, as there is a risk of developing a blood clot (very rare effect of Gamaglobin 16.5% Injection). So, inform your doctor if you notice any sign of a blood clot, such as pain, swelling and unusual warmth of a limb, weakness on one side of the body, confusion, sudden shortness of breath, chest pain worsening on deep breathing, and difficulty speaking. Gamaglobin 16.5% Injection should be used with caution in patients with kidney problems or who have taken medicines that may harm kidneys (nephrotoxic drugs) as Gamaglobin 16.5% Injection may cause problems with kidney function in these people. In rare cases, Gamaglobin 16.5% Injection may cause non-cardiogenic pulmonary oedema (accumulation of fluid in the lungs' air spaces, which is a non-heart related condition). In such cases, patients may experience breathing difficulty, bluish skin, and very low oxygen levels in the blood.

Therapeutic Class

IMMUNIZING AGENTS

Diet & Lifestyle Advise

  • Eat a healthy diet that includes grains,  fresh fruits, vegetables, lean meats, and dairy products. 
  • Stay active and do moderate exercises every day. Maintain a normal weight.
  • Get enough sleep, as sleep and immunity are closely related.
  • Limit intake of sugar-rich foods or drinks.
  • Stay hydrated. 
  • Practice good hygiene.
  • Manage stress levels. 

Habit Forming

No

What if I have taken an overdose of Gamaglobin 16.5% Injection

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.
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Alcohol

Safe if prescribed

Gamaglobin 16.5% Injection may not interact with alcohol. However, limit or avoid consumption of alcohol to avoid possible side effects.

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Pregnancy

Safe if prescribed

Inform your doctor if you are pregnant or planning pregnancy before receiving Gamaglobin 16.5% Injection. Your doctor will assess the benefits and the risks before prescribing.

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Breast Feeding

Safe if prescribed

Inform your doctor if you are breastfeeding before receiving Gamaglobin 16.5% Injection. Your doctor will assess the benefits and the risks before prescribing.

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Driving

Caution

Gamaglobin 16.5% Injection may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy after receiving this medicine.

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Liver

Caution

Gamaglobin 16.5% Injection should be used with caution in patients with liver diseases. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Caution

Gamaglobin 16.5% Injection should be used with caution in patients with kidney diseases. Your doctor may adjust the dose if necessary based on your condition.

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Children

Safe if prescribed

Gamaglobin 16.5% Injection can be safely used in children when prescribed.

Country of origin

India
Other Info - GAMA931

Author Details

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FAQs

Gamaglobin 16.5% Injection is used to treat immunoglobulin (antibody) deficiency and certain inflammatory disorders.
The Gamaglobin 16.5% Injection contains 'Human normal immunoglobulin', which helps restore the deficient immunoglobulins or antibodies in the body. Antibodies are an essential part of the immune system that helps to reduce infection and inflammation. They act by identifying, attacking, and thereby destroying the antigen or foreign body that has entered or is present in the body.
Gamaglobin 16.5% Injection may alter some blood test results for a certain time, so inform your doctor that you have Gamaglobin 16.5% Injection before undergoing blood tests. Taking any vaccines (especially live vaccines) at least three months after taking Gamaglobin 16.5% Injection is not recommended as this medicine may make the vaccines less effective.
Gamaglobin 16.5% Injection should be used with caution in patients with diabetes if this medicine is given as an infusion, as it may alter blood sugar levels. Gamaglobin 16.5% Injection doesn’t contain sugar; however, it can be diluted in a special sugar solution before giving the infusion.
Gamaglobin 16.5% Injection is usually well-tolerated. However, some patients may experience side effects such as swelling or hardening at the injection site and headache, pain in the face, back, arms, legs, joints, or neck, fever, flu-like illness (runny nose and sore throat), blisters in the mouth, and throat, and throat tightness. If any side effects persist or get worse, inform your doctor immediately.
It is a condition in which there is a decrease in antibody levels in the body due to decreased ability or inability to produce enough antibodies. It can be present from birth (primary) or acquired during the later stages of life (secondary).
Certain vaccinations, such as those for chickenpox, measles, mumps, and rubella, may become less effective when administered with Gamaglobin 16.5% Injection. Therefore, before receiving any vaccinations, inform your doctor if you are allergic to Gamaglobin 16.5% Injection. Let your doctor know that you are taking Gamaglobin 16.5% Injection. And also inform your doctor if you are breastfeeding, pregnancy or planning pregnancy.
No, you should not discontinue using Gamaglobin 16.5% Injection without consulting your doctor, even if you feel fine. Stopping the usage of Gamaglobin 16.5% Injection early can increase the risk of infections. Always follow your doctor's instructions and complete the prescribed course of treatment to ensure the best outcome.
The effects of Gamaglobin 16.5% Injection can vary depending on the individual and the condition being treated. Generally, it may take up to 4 weeks of regular therapy to notice a steady improvement in your symptoms. Therefore, complete the full course of treatment as prescribed by your doctor.
Yes, Gamaglobin 16.5% Injection can cause kidney damage but not in everyone. Patients having a pre-existing kidney problem, hypovolemia (a decrease in the volume of circulating blood) and diabetes are at risk of developing kidney failure. Additionally, patients who are overweight, above 65 years of age and who are taking medicines that can cause kidney damage are also at risk of developing kidney failure. Therefore, please inform your doctor if you have any pre-existing kidney problems.
No, hair loss is not a commonly reported side effect of Gamaglobin 16.5% Injection. If you experience hair loss, it might be due to some other underlying problem. Please consult your doctor if bothers you.
Gamaglobin 16.5% Injection benefits people with weakened immune systems, such as those who have undergone bone marrow transplants or have severely reduced antibody-forming capacity. It can also treat or prevent infections who are suffering with measles, hepatitis, and mumps. It is used for patients with primary immunodeficiency syndromes (PID) and acquired or secondary immunodeficiency (SID). Please consult your doctor if you have any concerns.
If you are pregnant, take your doctor’s advice before using Gamaglobin 16.5% Injection. Your doctor will assess the benefits and risks of Gamaglobin 16.5% Injection before prescribing.
Store Gamaglobin 16.5% Injection in a refrigerator (2 - 8°C). Do not freeze. Protect it from light. Keep out of reach of children.
No, Gamaglobin 16.5% Injection should not be self-administered. It is usually administered by a healthcare professional, such as a doctor or nurse.

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