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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Gabaprime-Trio Tablet is a combination medicine used to manage neuropathic pain due to damaged nerves. This medicine works by altering the nerve signals that cause pain and thereby protects nerve fibres. You may experience common side effects like dizziness, sleepiness, tiredness, headache, nausea, vomiting, dry mouth, and constipation.
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Manufacturer/Marketer :

Starus Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Gabaprime-Trio Tablet

Gabaprime-Trio Tablet is used to treat neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping, and evoked pain (pain caused by events that are usually not painful).
 
Gabaprime-Trio Tablet contains Gabapentin, methylcobalamin, and nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Methylcobalamin helps protect and rejuvenate the nerve cells and nerve fibres. Together, Gabaprime-Trio Tablet helps in providing relief from neuropathic pain.
 
You are advised to take Gabaprime-Trio Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Gabaprime-Trio Tablet may cause dizziness, sleepiness, tiredness, headache, nausea, vomiting, dry mouth, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant or breastfeeding. Gabaprime-Trio Tablet may cause sleepiness and dizziness, so drive only if you are alert. Limited data is available regarding the usage of Gabaprime-Trio Tablet in children, so please consult a doctor if you have any concerns. Avoid consuming alcohol with Gabaprime-Trio Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Gabaprime-Trio Tablet

Treatment of Neuropathic pain

Directions for Use

Swallow Gabaprime-Trio Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Gabaprime-Trio Tablet contains Gabapentin (anti-convulsant), Methylcobalamin (vitamin), and Nortriptyline (tricyclic antidepressant). Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline works by increasing the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Methylcobalamin helps protect and rejuvenate the nerve cells and nerve fibres. Together, Gabaprime-Trio Tablet helps in providing relief from neuropathic pain.

How Gabaprime-Trio Tablet Works

Gabaprime-Trio Tablet contains Gabapentin, methylcobalamin, and nortriptyline. Gabapentin works by binding to the specific site on voltage-gated calcium channels; this helps in relieving nerve pain. Nortriptyline increases the level of serotonin and noradrenaline, thereby decreasing the movement of pain receptors. Methylcobalamin helps protect and rejuvenate the nerve cells and nerve fibres. Together, Gabaprime-Trio Tablet helps in providing relief from neuropathic pain.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Gabaprime-Trio Tablet

  • Dizziness
  • Sleepiness
  • Tiredness
  • Headache
  • Nausea
  • Vomiting
  • Dry mouth
  • Constipation

What if I have taken an overdose of Gabaprime-Trio Tablet

Do not take more than the prescribed dose of Gabaprime-Trio Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Gabaprime-Trio Tablet if you are allergic to any of its contents. Inform your doctor if you have/had heart problems, bipolar syndrome, thyroid disorder, epilepsy, high blood pressure, diabetes, urinary retention, liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Gabaprime-Trio Tablet may cause sleepiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Gabaprime-Trio Tablet as it could lead to increased dizziness and sleepiness. Consult your doctor immediately if you experience suicidal tendencies. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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NortriptylinePotassium citrate
Critical
NortriptylineTranylcypromine
Critical

Drug-Drug Interactions

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NortriptylinePotassium citrate
Critical
How does the drug interact with Gabaprime-Trio Tablet 10's:
Coadministration of Gabaprime-Trio Tablet 10's with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Gabaprime-Trio Tablet 10's with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineTranylcypromine
Critical
How does the drug interact with Gabaprime-Trio Tablet 10's:
Coadministration of Gabaprime-Trio Tablet 10's with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Gabaprime-Trio Tablet 10's with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
NortriptylineZiprasidone
Critical
How does the drug interact with Gabaprime-Trio Tablet 10's:
Coadministration of Gabaprime-Trio Tablet 10's with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Gabaprime-Trio Tablet 10's with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
NortriptylineSelegiline
Critical
How does the drug interact with Gabaprime-Trio Tablet 10's:
Co-administration of Gabaprime-Trio Tablet 10's with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Gabaprime-Trio Tablet 10's with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineSafinamide
Critical
How does the drug interact with Gabaprime-Trio Tablet 10's:
Coadministration of Gabaprime-Trio Tablet 10's with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Gabaprime-Trio Tablet 10's with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
NortriptylineLinezolid
Critical
How does the drug interact with Gabaprime-Trio Tablet 10's:
Coadministration of Gabaprime-Trio Tablet 10's with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Gabaprime-Trio Tablet 10's with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Gabaprime-Trio Tablet 10's:
Using Gabaprime-Trio Tablet 10's together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Gabaprime-Trio Tablet 10's is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
GabapentinBuprenorphine
Severe
How does the drug interact with Gabaprime-Trio Tablet 10's:
Co-administration of Buprenorphine and Gabaprime-Trio Tablet 10's may cause central nervous system depression and lead to serious side effects (respiratory distress -build-up of fluid in the air sacs of the lungs).

How to manage the interaction:
Although there is a possible interaction between Gabaprime-Trio Tablet 10's and Buprenorphine, you can take these medicines together if prescribed by a doctor. However, if you experience shortness of breath, fast heart rate, fast breathing, extreme tiredness, fever, cough with phlegm, or shallow breaths, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
GabapentinFentanyl
Severe
How does the drug interact with Gabaprime-Trio Tablet 10's:
Taking fentanyl with other drugs that cause central nervous system depression, such as Gabaprime-Trio Tablet 10's, might result in an increased risk of adverse effects.

How to manage the interaction:
Although combining Fentanyl and Gabaprime-Trio Tablet 10's may cause an interaction, they can be used if advised by your doctor. Consult your doctor immediately if you feel drowsiness, trouble breathing, dizziness, or confusion. If you have any of the above symptoms, it is advised not to drive or use any hazardous machinery. Do not stop taking any medication without consulting your doctor.
GabapentinPethidine
Severe
How does the drug interact with Gabaprime-Trio Tablet 10's:
Combining Meperidine with Gabaprime-Trio Tablet 10's can increase the risk of CNS depression.

How to manage the interaction:
Co-administration of Pethidine with Gabaprime-Trio Tablet 10's can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.

  • Exercising regularly helps in improving overall health and combating pain. 

  • Rest well. Get optimum sleep.

  • Include cayenne pepper in your diet, as it can help in lowering neuropathic pain.

  • Try taking a warm bath, as it can be soothing.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.

  • Acupuncture can be helpful by stimulating pressure points.

  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Gabaprime-Trio Tablet Substitute

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Gabaprime-Trio Tablet as it may cause increased dizziness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Gabaprime-Trio Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Gabaprime-Trio Tablet may cause dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Limited information is available regarding the usage of Gabaprime-Trio Tablet in children. Please consult your doctor.

FAQs

Gabaprime-Trio Tablet is a combination medicine used to treat neuropathic pain. Neuropathic pain is a chronic progressive nerve disease which causes nerve pain.
Gabaprime-Trio Tablet works by binding to the specific site on voltage-gated calcium channels and decreases the movement of pain receptors. It also helps protect and rejuvenate the nerve cells and nerve fibres.
Gabaprime-Trio Tablet may cause constipation. Eat fibre-rich food and drink plenty of fluids if you experience constipation. If the condition persists or worsens, consult a doctor.
To treat your condition effectually, continue taking Gabaprime-Trio Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Gabaprime-Trio Tablet .
Dry mouth could be a side-effect of Gabaprime-Trio Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Gabaprime-Trio Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet. Consult your doctor if you have any concerns.
Gabaprime-Trio Tablet combines three medicines: Gabapentin, Methylcobalamin, and Nortriptyline. Together, they are used to treat neuropathic pain (nerve pain).
Peripheral neuropathy is a condition that happens when the nerves outside your brain and spinal cord (called peripheral nerves) are damaged. It mainly affects the nerves in your hands, feet, and arms. This can lead to numbness, tingling, weakness, and pain, usually in the hands or feet. Diabetes, infections, injuries, or certain medications can cause it.
Yes, Gabaprime-Trio Tablet may cause sleepiness or drowsiness in some people as a side effect. However, it's essential to note that everyone's response to Gabaprime-Trio Tablet can vary. If you're experiencing excessive sleepiness or concerns about Gabaprime-Trio Tablet , consult your doctor or pharmacist for personalized guidance.
No, it is crucial to follow the prescribed dosage for Gabaprime-Trio Tablet . Taking more than the recommended dose can increase the risk of side effects, such as dizziness, drowsiness, dry mouth, or even more serious complications. If you feel that the current dose is not practical or if your symptoms worsen, please consult your doctor. They can evaluate your situation and adjust the dose if needed.
Gabaprime-Trio Tablet should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of reach of children.
The common side effects of Gabaprime-Trio Tablet include dizziness, sleepiness, tiredness, headache, nausea, vomiting, dry mouth, and constipation. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

INDIA

Manufacturer/Marketer address

STARUS PHARMACEUTICALS PRIVATE LIMITED, 1st FLOOR, MOPARTHY TOWERS, LANE BESIDE KARACHI BAKERY, ROAD NO:1, BANJARA HILLS, HYDERABAD-500034, INDIA
Other Info - GAB0227

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