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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Fosfa with Mesna Injection is used in the treatment of different kinds of cancer, such as blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer, and pancreatic cancer. Sometimes, you may experience specific side effects such as nausea, diarrhoea, vomiting, loss of appetite, headache, dizziness, hair loss, abdominal pain, pain or redness at the injection site, fever, sore throat, and cough. Before receiving this medicine, you should inform your doctor if you are allergic to any of its ingredients or if you are pregnant or breastfeeding, and about all the medications you are taking and any pre-existing medical conditions to rule out the potential side effects.

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Manufacturer/Marketer :

Getwell Oncology Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Fosfa with Mesna Injection

Fosfa with Mesna Injection is used to treat different cancers such as Blood, breast, non-small cell, ovarian, testicular, and pancreatic cancer. Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. These cells can form tumours or spread to other body parts, interfering with normal function.

Fosfa with Mesna Injection is a combination medication. It contains ifosfamide (antineoplastic agent) and mesna (cytoprotectants). Fosfa with Mesna Injection works by damaging the genetic material (DNA and RNA) of cancer cells, stopping their growth and multiplication. 

Sometimes, you may experience specific side effects such as nausea, diarrhoea, vomiting, loss of appetite, headache, dizziness, hair loss, abdominal pain, pain or redness at the injection site, fever, sore throat, and cough. Most of these side effects will resolve gradually over time and do not require medical attention. However, consult the doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Fosfa with Mesna Injection may cause dizziness. Therefore, avoid driving or operating heavy machinery unless you are fully alert. Fosfa with Mesna Injection is safe for children if prescribed by the doctor. Fosfa with Mesna Injection should not be given to children as its safety and efficacy have not been established. Consumption of alcohol is not recommended while receiving this Fosfa with Mesna Injection as it may increase the risk of adverse effects such as dizziness, drowsiness, abnormal muscle movements, and seizures. Inform your doctor about your pre-existing medical conditions and if you are taking any other medications to prevent potential side effects.

Uses of Fosfa with Mesna Injection

Fosfa with Mesna Injection is used in the treatment of Blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer, and pancreatic cancer.

Directions for Use

Fosfa with Mesna Injection will be administered by a healthcare professional through the Intravenous route. Do not self-administer.

Medicinal Benefits

Fosfa with Mesna Injection belongs to the group of medicines called antineoplastic agents. Fosfa with Mesna Injection is a combination of two drugs, Ifosfamide (antineoplastic agent) and mesna (cytoprotectants), used to treat different kinds of cancers such as blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer, and pancreatic cancer. Fosfa with Mesna Injection works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication. Mesna is used along with ifosfamide to protect the bladder from toxic side effects, particularly haemorrhagic cystitis.

How Fosfa with Mesna Injection Works

Fosfa with Mesna Injection contains Ifosfamide (an antineoplastic agent) and mesna (cytoprotectant). Ifosfamide damages the genetic material (DNA and RNA) of cancer cells, stopping their growth and multiplication. Mesna is used along with ifosfamide to protect the bladder from toxic side effects, particularly haemorrhagic cystitis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Fosfa with Mesna Injection

  • Nausea
  • Vomiting
  • Abdominal pain
  • Diarrhoea
  • Dizziness
  • Loss of appetite
  • Headache
  • Hair loss
  • Pain or redness at the injection site
  • Fever
  • Sore throat
  • Cough

What if I have taken an overdose of Fosfa with Mesna Injection

Since the doctor or nurse will administer the medication, the risk of overdose is minimal. However, in the case of any accidental overdose, it is essential to contact the doctor immediately for prompt care and ensure the patient is closely monitored.

Drug Warnings

Fosfa with Mesna Injection should not be administered to individuals if they are allergic to it or its ingredients. Women of childbearing age should use effective birth control during treatment and for at least six months after the last dose to avoid pregnancy. Regular urine and blood tests, including CBC, are required to monitor blood cell counts while receiving Fosfa with Mesna Injection. Fosfa with Mesna Injection is not intended for use in conditions like haematuria due to thrombocytopenia or other underlying diseases. It may cause blurry vision and dizziness; therefore, avoid driving or operating heavy machinery while treating with Fosfa with Mesna Injection. Inform your doctor if you have a history of kidney, heart, liver disease, cystitis, or CNS toxicity before starting therapy with Fosfa with Mesna Injection. Avoid the consumption of alcohol as it may cause interactions and lead to unpleasant side effects. Fosfa with Mesna Injection is unsafe during pregnancy and breastfeeding. Patients with infections should exercise caution, and chemotherapy may be temporarily stopped if fever or signs of infection occur. Fosfa with Mesna Injection may cause bone marrow suppression, decreasing white blood cells and platelets, so regular monitoring is essential.

Drug-Drug Interactions

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IfosfamideCidofovir
Critical
IfosfamideClozapine
Severe

Drug-Drug Interactions

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IfosfamideCidofovir
Critical
How does the drug interact with Fosfa with Mesna Injection 1's:
Taking cidofovir with Fosfa with Mesna Injection 1's can increase the risk of kidney problems.

How to manage the interaction:
Taking Fosfa with Mesna Injection 1's with Cidofovir together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
IfosfamideClozapine
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Co-administration of Fosfa with Mesna Injection 1's with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
Taking Fosfa with Mesna Injection 1's with Clozapine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection like fever, chills, or a sore throat, or experience discomfort while urinating, it's best to contact a doctor right away. Do not stop using any medications without a doctor's advice.
IfosfamideTofacitinib
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Taking Fosfa with Mesna Injection 1's with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
Taking Tofacitinib with Fosfa with Mesna Injection 1's together can possibly result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on your condition. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
IfosfamideThalidomide
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Taking thalidomide together with Fosfa with Mesna Injection 1's may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Fosfa with Mesna Injection 1's together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
IfosfamideBaricitinib
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Coadministration of baricitinib and Fosfa with Mesna Injection 1's can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Fosfa with Mesna Injection 1's if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
IfosfamideTenofovir alafenamide
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
The combined use of Fosfa with Mesna Injection 1's and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Fosfa with Mesna Injection 1's and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
IfosfamideLidocaine
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Coadministration of Fosfa with Mesna Injection 1's with Lidocaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
There may be a possibility of interaction between Fosfa with Mesna Injection 1's and Lidocaine, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
IfosfamideCladribine
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Combining Cladribine with Fosfa with Mesna Injection 1's can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Fosfa with Mesna Injection 1's and Cladribine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
IfosfamideInfliximab
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Combining Infliximab with Fosfa with Mesna Injection 1's can speed up the breakdown of Fosfa with Mesna Injection 1's in the body. This can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Fosfa with Mesna Injection 1's with Infliximab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, contact a doctor right away. Don't hesitate to reach out to your doctor if you experience any of these. Do not stop using any medications without a doctor's advice.
IfosfamideBupivacaine
Severe
How does the drug interact with Fosfa with Mesna Injection 1's:
Taking Bupivacaine and Fosfa with Mesna Injection 1's may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking bupivacaine and Fosfa with Mesna Injection 1's together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat protein-rich, low-fat foods like eggs, Greek yoghurt, seafood, lean meats, poultry, beans, soy products, and unsalted nuts.
  • Include vitamin A-rich foods like carrots, sweet potatoes, kale, spinach, and apricots.
  • Avoid intake of fatty, fried, spicy, and overly sweet foods to avoid nausea.
  • Practise good hygiene by staying away from crowded places, and avoiding raw and undercooked food to reduce the risk of infection.
  • Avoid refined sugars and carbohydrates, as tumours often use glucose for energy.
  • Avoid consumption of alcohol and quit smoking.
  • Empty your bladder frequently within 24 hours of chemotherapy; inform your doctor if you experience pain during urination.
  • Get at least 8 hours of sleep and rest regularly.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Fosfa with Mesna Injection Substitute

Substitutes safety advice
  • Holoxan 100mg/2gm Injection

    1150.20per tablet
  • Ifowem 2gm Injection Combipack

    575.14per tablet
  • Ifex-M 2 g Injection 1's

    823.50per tablet
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Alcohol

Unsafe

Avoid alcohol consumption while treatment with Fosfa with Mesna Injection as it may cause unpleasant side effects.

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Pregnancy

Unsafe

Fosfa with Mesna Injection is not recommended to be used in pregnancy as it may cause serious side effects. Use effective birth control measures during treatment with Fosfa with Mesna Injection and for 6 months after completing the treatment. Inform your doctor If you get pregnant while you are receiving Fosfa with Mesna Injection.

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Breast Feeding

Unsafe

Fosfa with Mesna Injection is excreted in breast milk. Ifosfamide has been demonstrated to produce significant adverse effects and tumours in animal tests. It is essential to consider the importance of the medicine to the mother before discontinuing nursing. Ifosfamide should not be taken by women who are breastfeeding.

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Driving

Caution

Some patients may experience blurred vision or dizziness after using this $ name. If you experience any of these symptoms during treatment, do not drive a vehicle or operate heavy machinery.

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Liver

Caution

There were no official investigations undertaken on patients with liver impairment. Fosfa with Mesna Injection is metabolized extensively in the liver, producing both beneficial and harmful metabolites. It should be administered with caution to patients with poor liver function.

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Kidney

Caution

There were no official studies undertaken on people with kidney impairment. The kidneys eliminate Fosfa with Mesna Injection and metabolites but may accumulate in plasma with impaired renal function. Patients with renal impairment should be continuously watched for toxicity, and dose reduction may be necessary.

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Children

Caution

Fosfa with Mesna Injection is not recommended for use in children under 12 years of age as its safety and efficacy have not been established.

FAQs

Fosfa with Mesna Injection belongs to the group of medications called antineoplastic agents. It is used to treat blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer and pancreatic cancer.
Fosfa with Mesna Injection is an antineoplastic agent. It works by damaging the DNA of cancer cells, preventing their growth and spread. Mesna is used along with ifosfamide to protect the bladder from toxic side effects, particularly haemorrhagic cystitis.
Fosfa with Mesna Injection may cause diarrhoea as a common side effect. If you experience this symptom, drink plenty of fluids to stay hydrated, eat non-spicy food, get plenty of rest, and take probiotics. Do not take anti-diarrheal medicines on your own without a doctor’s advice.
The side effects of Fosfa with Mesna Injection include nausea, diarrhoea, vomiting, loss of appetite, headache, dizziness, hair loss, abdominal pain, pain or redness at the injection site, fever, sore throat, and cough. Most of these side effects will resolve gradually over time and do not require medical attention. However, consult the doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

464, Udyog Vihar, Phase-V Sector 19, Gurugram Haryana 122016
Other Info - FOS0077

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Keep Refrigerated. Do not freeze.

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