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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Folitrax-50 Injection 2 ml belongs to the class of antimetabolite medications used in the treatment of polyarticular juvenile rheumatoid arthritis, psoriasis, breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, bone cancer, and advanced stage non-Hodgkin's lymphomas. This medicine works by interfering with the immune system process that causes inflammation and prevents the growth of cancer-causing cells.
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Composition :

METHOTREXATE-25MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Folitrax-50 Injection 2 ml

Folitrax-50 Injection 2 ml belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis, including polyarticular juvenile rheumatoid arthritis and severe psoriasis. Folitrax-50 Injection 2 ml is also used to treat cancer such as breast cancer, cervical cancer, bladder cancer, ovarian cancer, testicular cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), bone cancer, and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system).

Folitrax-50 Injection 2 ml contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Folitrax-50 Injection 2 ml prevents and stops the growth of cancer cells, thereby helps treat cancer. Folitrax-50 Injection 2 ml treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis.

Folitrax-50 Injection 2 ml will be administered by a qualified healthcare professional; do not self-administer. In some cases, Folitrax-50 Injection 2 ml may cause side-effects such as nausea, vomiting, diarrhoea, unusual fatigue, dizziness, headache, loss of appetite, lowered resistance to infections, tingling sensation, leukopenia (decreased number of white blood cells), and soreness of mouth and lips. You are advised to talk to your doctor if you experience any of the side effects persistently.

Do not take Folitrax-50 Injection 2 ml if you are pregnant or breastfeeding. Folitrax-50 Injection 2 ml may cause dizziness and fatigue, so avoid driving or operating machinery. Avoid consuming alcohol whilst on treatment with Folitrax-50 Injection 2 ml. If you are due to undergo any surgery, including dental surgery, inform the doctor that you are receiving Folitrax-50 Injection 2 ml. Do not have any vaccinations during treatment with Folitrax-50 Injection 2 ml without consulting your doctor. Inform your doctor about your medications and health condition to rule out any unpleasant side effects.

Uses of Folitrax-50 Injection 2 ml

Treatment of Rheumatoid arthritis, Psoriasis and Cancer

Directions for Use

Folitrax-50 Injection 2 ml will be administered by a qualified healthcare professional; do not self-administer.

Medicinal Benefits

Folitrax-50 Injection 2 ml belongs to the class of medicines called 'anti-metabolites and immunosuppressants' used to treat active rheumatoid arthritis including polyarticular juvenile rheumatoid arthritis (arthritis in children) and severe psoriasis. Folitrax-50 Injection 2 ml helps treat rheumatoid arthritis by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Folitrax-50 Injection 2 ml treats psoriasis by suppressing the overactive immune system that is responsible for causing psoriasis. Folitrax-50 Injection 2 ml is used to treat breast cancer, lung cancer, head and neck cancer, mycosis fungoides (type of blood cancer), and advanced stage non-Hodgkin's lymphomas (cancer that starts in the lymphatic system). Folitrax-50 Injection 2 ml prevents and stops the growth of cancer cells by interfering with DNA production.

How Folitrax-50 Injection 2 ml Works

Folitrax-50 Injection 2 ml contains 'Methotrexate' that works by interrupting the processes of the immune system that cause inflammation in the joint tissues. It reduces pain and inflammation and delays joint damage and disease progression over time. Besides this, Folitrax-50 Injection 2 ml prevents and stops the growth of cancer cells, thereby helps treat cancer.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Folitrax-50 Injection 2 ml

  • Nausea
  • Vomiting
  • Diarrhoea
  • Unusual fatigue
  • Dizziness
  • Headache
  • Loss of appetite
  • Elevated liver enzymes
  • Lowered resistance to infections
  • Tingling sensation
  • Leukopenia (decreased number of white blood cells)
  • Soreness of mouth and lips

What if I have taken an overdose of Folitrax-50 Injection 2 ml

Folitrax-50 Injection 2 ml is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Symptoms of overdose may include vomiting, diarrhoea and gastrointestinal bleeding, as well as severe bone marrow suppression and disturbance of liver function. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

Do not take Folitrax-50 Injection 2 ml if you are allergic to any of its contents; if you are pregnant or breastfeeding. Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anaemia, liver problems due to alcohol abuse, liver, lung or kidney problems, ulceration in the stomach or bowels, poor general condition, received any vaccinations or if are due to have any, diabetes, ascites (fluid in the stomach area), lung problems or fluid in the lungs. Folitrax-50 Injection 2 ml may cause a serious, life-threatening reaction. If you experience symptoms such as rash, itching, hives, throat tightness, trouble swallowing, swelling of the face, throat, lips, or tongue; runny or stuffy nose, lightheadedness or dizziness, chest pain, difficulty breathing, wheezing, or feeling faint, consult your doctor immediately. Inform your doctor if you are undergoing radiation therapy; if you receive Folitrax-50 Injection 2 ml while you are being treated with radiation therapy for cancer, it may cause damage to the skin, bones, or other parts of the body.

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
MethotrexateHydroxychloroquine
Severe

Drug-Drug Interactions

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MethotrexateEtretinate
Critical
How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Etretinate with Folitrax-50 Injection 2 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Taking Etretinate with Folitrax-50 Injection 2 ml is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
MethotrexateHydroxychloroquine
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Combine use of hydroxychloroquine with Folitrax-50 Injection 2 ml may increase the effectiveness of everolimus.

How to manage the interaction:
Although there is a possible interaction between hydroxychloroquine and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, dizziness. Consult your doctor. Do not stop using any medications without first consulting to your doctor.
MethotrexateOmeprazole
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of omeprazole with Folitrax-50 Injection 2 ml may increase the levels and side effects of omeprazole.

How to manage the interaction:
Although there is a possible interaction between omeprazole and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting to a doctor.
MethotrexatePantoprazole
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Folitrax-50 Injection 2 ml with pantoprazole can increase the levels and side effects of Folitrax-50 Injection 2 ml.

How to manage the interaction:
Although there is a possible interaction between pantoprazole and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, tiredness, weakness, or dizziness, consult a doctor. Do not stop using any medications without consulting a doctor.
MethotrexateEverolimus
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of Everolimus with Folitrax-50 Injection 2 ml can increase the risk or severity of kidney disorders.

How to manage the interaction:
Taking Everolimus with Folitrax-50 Injection 2 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
MethotrexateSirolimus
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Sirolimus with Folitrax-50 Injection 2 ml can increase the risk or severity of kidney damage.

How to manage the interaction:
Although there is a possible interaction between sirolimus and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
MethotrexateEtodolac
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Folitrax-50 Injection 2 ml with etodolac can increase the level and effects of Folitrax-50 Injection 2 ml. This can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Folitrax-50 Injection 2 ml and etodolac, you can take these medicines together if prescribed by a doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
MethotrexateTrimethoprim
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of trimethoprim with Folitrax-50 Injection 2 ml can increase the risk or severity of blood disorders.

How to manage the interaction:
Although there is a possible interaction between trimethoprim and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as pale skin, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
MethotrexateAspirin
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Co-administration of Folitrax-50 Injection 2 ml with aspirin can increase the levels and side effects of Folitrax-50 Injection 2 ml.

How to manage the interaction:
Although there is a possible interaction between aspirin and Folitrax-50 Injection 2 ml, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience symptoms such as nausea, vomiting, diarrhea, sore throat, chills, fever, rash, unusual bruising or bleeding, pale skin, dark urine, swelling of the legs and hands, breathing difficulty. Do not stop using any medications without consulting a doctor.
MethotrexatePiroxicam
Severe
How does the drug interact with Folitrax-50 Injection 2 ml:
Coadministration of Folitrax-50 Injection 2 ml with piroxicam can increase the levels and side effects.

How to manage the interaction:
Although there is a possible interaction between piroxicam and Folitrax-50 Injection 2 ml, it can be taken if prescribed by a doctor. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Arthritis:

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle exercises like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help reduce inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Psoriasis:

  • Include foods such as cherries, berries, leafy vegetables, salmon, sardines, and fish rich in omega-3 fatty acids.
  • Consume antioxidant-rich spices and herbs like cumin, ginger, sage and thyme.
  • Avoid processed foods, refined sugars, and fatty foods.
  • Limit intake of food that might trigger allergies, such as dairy products, soy, eggs, and nuts.
  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.
  • Reducing stress and maintaining a good sleep cycle would be helpful.
  • Avoiding getting in contact with harsh soaps, detergents and rough fabrics.

Cancer:

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

Folitrax-50 Injection 2 ml Substitute

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  • Methora 25 Tablet 10's

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Folitrax-50 Injection 2 ml.

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Pregnancy

Unsafe

Folitrax-50 Injection 2 ml may cause serious birth defects. It is not recommended to take Folitrax-50 Injection 2 ml while you are pregnant.

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Breast Feeding

Unsafe

Folitrax-50 Injection 2 ml passes into breast milk. Avoid breastfeeding whilst on treatment with Folitrax-50 Injection 2 ml and for at least 1 week after the last dose.

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Driving

Caution

Folitrax-50 Injection 2 ml may cause dizziness and tiredness; do not drive or operate heavy machinery until you know how Folitrax-50 Injection 2 ml affects you.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Folitrax-50 Injection 2 ml.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Folitrax-50 Injection 2 ml.

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Children

Caution

The efficacy and safety of Folitrax-50 Injection 2 ml in children have been established in polyarticular-course juvenile rheumatoid arthritis and cancer chemotherapy. Please consult your doctor if you have any concerns regarding the usage of Folitrax-50 Injection 2 ml in children.

FAQs

Folitrax-50 Injection 2 ml acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby providing relief from rheumatoid arthritis.
Folitrax-50 Injection 2 ml works by suppressing the overactive immune system that is responsible for causing psoriasis. Folitrax-50 Injection 2 ml interferes with the synthesis of genetic material (DNA) and the growth of cells that multiply faster than usual, thereby helping in treating psoriasis.
Folitrax-50 Injection 2 ml may affect fertility in men and women. Consult your doctor if you have any concerns regarding this.
Folitrax-50 Injection 2 ml causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
Folitrax-50 Injection 2 ml may make your skin sensitive to sunlight. Therefore, avoid prolonged or unnecessary exposure to sunlight or ultraviolet light such as tanning beds and sunlamps. Wear protective clothing, sunglasses, and sunscreen while going out.

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - FOL0010

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