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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Fivotop 500 Injection is used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer. It contains Fluorouracil which works by preventing the cancer cells from multiplying and eventually kills them. In some cases, this medicine may cause side effects such as nausea, vomiting, weakness, loss of appetite, increased risk of infection, hair loss, diarrhoea, decreased blood cells, and mouth ulcers. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

FLUOROURACIL-500MG

Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Fivotop 500 Injection

Fivotop 500 Injection belongs to a group of anti-cancer medicines called 'antimetabolites' used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer. Cancer is a disease in which cells divide uncontrollably. Cancer can be localized (benign) or spread to the whole body (metastasized). 

Fivotop 500 Injection contains 'Fluorouracil' that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them.

In some cases, Fivotop 500 Injection may cause nausea, vomiting, weakness, loss of appetite, increased risk of infection, hair loss, diarrhoea, decreased blood cells, and mouth ulcers. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Inform your doctor if you have a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency, heart problems, bone marrow depression, kidney disease, liver disease, or if you are on treatment with chemotherapy or radiation. Avoid taking Fivotop 500 Injection if you are pregnant or breastfeeding. Both women and men on treatment with Fivotop 500 Injection should use birth control to avoid pregnancy. 

Uses of Fivotop 500 Injection

Treatment of Breast, colon, rectum, pancreatic and stomach/gastric cancer

Directions for Use

It will be administered by a healthcare professional. Do not self-administer.

Medicinal Benefits

Fivotop 500 Injection belongs to a group of anti-cancer medicines called 'antimetabolites' used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer. Fivotop 500 Injection contains 'Fluorouracil' that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them.

How Fivotop 500 Injection Works

Fivotop 500 Injection contains 'Fluorouracil' that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Fivotop 500 Injection

  • Nausea
  • Vomiting
  • Weakness
  • Loss of appetite
  • Increased risk of infection
  • Hair loss
  • Diarrhoea
  • Decreased blood cells 
  • Mouth ulcer

What if I have taken an overdose of Fivotop 500 Injection

Since Fivotop 500 Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Inform your doctor if you have any infection, a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency, heart problems, bone marrow depression, kidney disease, liver disease, or if you are on treatment with chemotherapy or radiation. Consult your doctor if you are pregnant because Fivotop 500 Injection can cause harmful effects on the unborn baby. Women and men using Fivotop 500 Injection should use birth control to avoid pregnancy. The use of Fivotop 500 Injection by either parent may result in congenital disabilities. Fivotop 500 Injection should be used with caution in elderly patients. If you have had leukaemia (blood cancer) and are in remission, do not take live vaccines for three months after your last chemotherapy.

Drug-Drug Interactions

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FluorouracilThalidomide
Severe
FluorouracilWarfarin
Severe

Drug-Drug Interactions

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FluorouracilThalidomide
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Taking thalidomide together with Fivotop 500 Injection 10 ml may increase the risk of blood clots and that may lead to serious complications.

How to manage the interaction:
Although taking thalidomide and Fivotop 500 Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
FluorouracilWarfarin
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Taking Warfarin together with Fivotop 500 Injection 10 ml may increase the risk of bleeding.

How to manage the interaction:
Although taking Warfarin and Fivotop 500 Injection 10 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience symptoms such as unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not stop using any medications without consulting a doctor.
FluorouracilFolic acid
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Co-administration of Folic acid with Fivotop 500 Injection 10 ml may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Folic acid and Fivotop 500 Injection 10 ml, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FluorouracilCladribine
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Combining Cladribine with Fivotop 500 Injection 10 ml can increase the risk of side effects.

How to manage the interaction:
Taking Cladribine with Fivotop 500 Injection 10 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
FluorouracilClozapine
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Co-administration of Fivotop 500 Injection 10 ml with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Fivotop 500 Injection 10 ml and Clozapine, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
FluorouracilFolic acid
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Coadministration of Folic acid and Fivotop 500 Injection 10 ml may increase the effects of Fivotop 500 Injection 10 ml and increase the risk of serious side effects such as bleeding problems, anaemia (lack of blood), infections, and nerve damage.

How to manage the interaction:
Although there is a possible interaction between Folic acid and Fivotop 500 Injection 10 ml, you can take these medicines together if prescribed by your doctor. However, if you experience diarrhoea, paleness of skin, severe nausea and vomiting, over-tiredness, dizziness, fainting, blood in the stools, unusual bleeding or bruising, fever, chills, body pains, flu-like symptoms, skin reactions, mouth ulcers or sores, and/or numbness, burning or tingling in your hands and feet, contact your doctor.
FluorouracilInfliximab
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Using Infliximab together with Fivotop 500 Injection 10 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab together with Fivotop 500 Injection 10 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
FluorouracilMitomycin
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Taking Fivotop 500 Injection 10 ml with mitomycin has been associated with a condition known as hemolytic uremic syndrome (HUS) and using it with Fivotop 500 Injection 10 ml may increase that risk.

How to manage the interaction:
Although taking Mitomycin and Fivotop 500 Injection 10 ml together can cause an interaction, it can be taken if your doctor has suggested it. Do not discontinue any medications without first consulting a doctor.
FluorouracilThalidomide
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Using thalidomide together with Fivotop 500 Injection 10 ml can increase the risk of dangerous blood clots

How to manage the interaction:
Although there is a possible interaction between Thalidomide and Fivotop 500 Injection 10 ml, but it can be taken together if prescribed by your doctor. However, consult a doctor immediately if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness or swelling in an arm or leg Do not stop using any medications without a doctor's advice.
FluorouracilTofacitinib
Severe
How does the drug interact with Fivotop 500 Injection 10 ml:
Using tofacitinib together with Fivotop 500 Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Although there is a interaction between tofacitinib and Fivotop 500 Injection 10 ml but can be taken if advised by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.

  • Avoid smoking and alcohol consumption.

  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.

  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

  • Get optimal sleep, and rest well.

Habit Forming

No

Therapeutic Class

ANTIMETABOLITES

Fivotop 500 Injection Substitute

Substitutes safety advice
  • Flurasted 500 Injection 10 ml

    2.70per tablet
  • ONCOFLUOR 500MG INJECTION 10ML

    2.51per tablet
  • 5 Flucel 500 Injection 10 ml

    2.38per tablet
  • 5 FU-GLS 500 Injection 10 ml

    2.43per tablet
  • Raciwel 500 Injection 10 ml

    3.06per tablet
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Alcohol

Caution

You are recommended to avoid alcohol consumption while on treatment with Fivotop 500 Injection to prevent unpleasant side effects. Alcohol intake, along with Fivotop 500 Injection, may cause increased drowsiness.

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Pregnancy

Unsafe

It is not recommended for pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Fivotop 500 Injection.

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Breast Feeding

Unsafe

It is not recommended for breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Fivotop 500 Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe

Fivotop 500 Injection does not affect your driving ability.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Fivotop 500 Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a history of kidney diseases, inform your doctor before receiving Fivotop 500 Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Fivotop 500 Injection is not recommended for children, as efficacy and safety have not been established.

FAQs

Fivotop 500 Injection is used to treat breast, colon, rectum, pancreatic and stomach/gastric cancer.
Fivotop 500 Injection works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Yes, Fivotop 500 Injection affects the hair by making it thin, which further causes hair loss. However, it is not very common. Hair reduction possibly happens due to the estrogen-lowering effect of Fivotop 500 Injection. These effects are not long-lasting and may return after some time. If it matters to you, then consult your doctor for further advice.
Yes, Fivotop 500 Injection may change the results of blood tests and other laboratory tests. Inform the person doing the tests that you are taking Fivotop 500 Injection.
$nanme might affect fertility (ability to have children) in both men and women. You may not be able to become pregnant or father a child after treatment with Fivotop 500 Injection. However, it is essential to talk to your doctor before starting treatment with Fivotop 500 Injection if you think you may want to have a baby in the future.

Country of origin

India

Manufacturer/Marketer address

A/303, Atrium -1, Andheri - Kurla Road, Mumbai 400 059 India
Other Info - FIV0020

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