Ezisartan RM 40mg/5mg Tablet belongs to a group of medications called ‘antihypertensives’ used in the treatment of hypertension (high blood pressure). High blood pressure is a chronic (long-term) condition in which blood pressure is elevated persistently in higher than normal levels. If left untreated, this condition can increase the risk of heart-related diseases like heart attack, heart failure, stroke, irregular heartbeat, and other complications.

Ezisartan RM 40mg/5mg Tablet contains Telmisartan and Ramipril. Telmisartan is an angiotensin-II receptor blocker (ARB). Angiotensin narrows the blood vessels increasing the blood pressure, therefore blocking angiotensin can result in the widening of the narrowed blood vessels. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor and works by lowering the body’s production of substances (angiotensin) that could increase blood pressure. Together, Ezisartan RM 40mg/5mg Tablet allows the blood to flow more smoothly in the blood vessels.

Take Ezisartan RM 40mg/5mg Tablet exactly as prescribed. Ezisartan RM 40mg/5mg Tablet may cause side effects such as sinus pain and congestion, back pain, dizziness, hypotension (abnormally low blood pressure), especially when you stand or sit up quickly, dry cough, weakness, stomach pain, diarrhea, indigestion, feeling or being sick, skin rash, chest pain, muscle cramps and hyperkalemia (increased potassium levels in the blood). Inform your doctor immediately, if any of these side effects persist or get worse.

It is not recommended to take Ezisartan RM 40mg/5mg Tablet if you are allergic to any contents of it. Before taking Ezisartan RM 40mg/5mg Tablet, inform your doctor if you have any liver, kidney or heart problems, angioedema (serious allergic reaction), renal artery stenosis (a kidney problem in which blood supply to the kidney is reduced), severe hypotension (abnormally low blood pressure), atherosclerosis (obstruction of blood flow due to presence of clots) and diabetic kidney disease. It is also not recommended for use in children, and pregnant and breastfeeding women. The dose may have to be adjusted in elderly people. It is not advised to consume alcohol as it can increase dizziness. Ezisartan RM 40mg/5mg Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Ezisartan RM 40mg/5mg Tablet is used in the treatment of hypertension and essential hypertension (that doesn't have an identifiable cause). It works by lowering the body’s production of substances that could increase blood pressure and also widens narrowed blood vessels. It allows the blood to flow more smoothly in the blood vessels. It can reduce the risk of heart failure, stroke and delay worsening of kidney problems. It can also be given as a treatment for chronic heart failure.

• Back pain
• Sinus pain and congestion
• Dizziness
• Hypotension (abnormally low blood pressure), especially when you stand or sit up quickly
• Dry cough
• Weakness
• Stomach pain
• Diarrhea
• Indigestion
• Feeling or being sick
• Skin rash
• Chest pain
• Muscle cramps
• Hyperkalemia (increased potassium levels in the blood)

Ezisartan RM 40mg/5mg Tablet may cause hypotension (low blood pressure) and result in dizziness or fainting. The risk is high in patients who are taking water pills, are on a low-sodium diet, undergoing dialysis treatment, have heart problems and suffering from severe vomiting and diarrhea. Regularly check your blood pressure levels to avoid any risk. Ezisartan RM 40mg/5mg Tablet may affect kidney function and alter kidney test results. So, it should be used with caution in patients with kidney diseases. If you notice swelling in the hands, feet or ankles, inform your doctor immediately as it can be a sign of kidney problems. Ezisartan RM 40mg/5mg Tablet should also be used with caution in patients who are taking treatment for allergy, have hyperkalemia (high potassium levels), have adrenal gland problems and have systemic lupus erythematosus (a skin disease).

Drug-Drug Interactions: Ezisartan RM 40mg/5mg Tablet may interact with non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen and indomethacin), pain killer(aspirin), medicines used for the treatment of low blood pressure, shock, cardiac failure or allergies (ephedrine, noradrenaline), medicine used to treat long-term heart failure (sacubitril,valsartan), medicine that suppress immune system (ciclosporin, sirolimus and everolimus), water pill (furosemide), medicines which can increase the amount of potassium in your blood (spironolactone, triamterene, amiloride, trimethoprim and trimethoprim, sulfamethoxazole), blood thinner (heparin), steroid medicine (prednisolone), medicine to treat gout (allopurinol), medicine to treat heart rhythm problems (procainamide), antibacterial (co-trimoxazole), medicine used to treat cancer (temsirolimus), antipsychotics, medicine used to treat type 2 diabetes (vildagliptin and insulin), medicine used to treat diarrhea (racecadotril), medicine to treat high blood pressure (aliskiren), medicine used to treat heart diseases (digoxin) antidepressant (lithium).

Drug-Food Interactions: Ezisartan RM 40mg/5mg Tablet may interact with alcohol and increase dizziness.

Drug-Disease Interactions: Ezisartan RM 40mg/5mg Tablet should not be used in patients with angioedema (serious allergic reaction), renal artery stenosis (a kidney problem in which blood supply to the kidney is reduced), diabetic kidney disease and severe hypotension (abnormally low blood pressure). It should be used with caution in patients with liver, kidney or heart diseases.

• IBUPROFEN
• INDOMETHACIN
• ASPIRIN
• EPHEDRINE
• NORADRENALINE
• SACUBITRIL+VALSARTAN
• CICLOSPORIN
• SIROLIMUS
• EVEROLIMUS
• FUROSEMIDE
• SPIRONOLACTONE
• TRIAMTERENE
• AMILORIDE
• TRIMETHOPRIM
• TRIMETHOPRIM+SULFAMETHOXAZOLE
• HEPARIN
• PREDNISOLONE
• ALLOPURINOL
• PROCAINAMIDE
• TEMSIROLIMUS
• COTRIMOXAZOLE
• VIDAGLIPTIN
• INSULIN
• RACECADOTRIL
• ALISKIREN
• DIGOXIN
• LITHIUM

• Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
• Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
• Limit alcohol intake. One serving for women and two servings for men is advisable.
• Quit smoking as it is the best strategy to lower the risk of heart disease.
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• Try to include heart-healthy omega-3 fatty acids containing food and drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• Ezisartan RM 40mg/5mg Tablet may cause acute renal failure (kidney dysfunction), so it is not recommended for use in patients with severe kidney damage, atherosclerosis (obstruction of blood flow due to the presence of clots), and diabetes with end-organ damage (damage occurring in major organs such as heart, kidney, eyes, and brain). 
• Inform your doctor before undergoing any surgery or dental procedure that you are taking Ezisartan RM 40mg/5mg Tablet as it is recommended to stop this medicine one day before the procedures.
• Monitor your blood pressure regularly while using Ezisartan RM 40mg/5mg Tablet to make sure it is working properly.
• Your doctor may also monitor glucose levels, kidney function, and electrolyte levels at regular intervals during the treatment with Ezisartan RM 40mg/5mg Tablet.
• You should not discontinue using Ezisartan RM 40mg/5mg Tablet without consulting your doctor.

Hypertension: It is a chronic (long-term) condition in which blood pressure is elevated persistently at higher than normal levels. It occurs when the blood’s force against the wall of blood vessels is too high. This condition can cause chest pain (angina) and heart attack (when the blood supply to the heart is blocked). Additionally, high blood pressure also causes damage to the brain, kidneys and eyes. The risk of high blood pressure complications increases with the following: obesity, smoking, diabetes, alcohol intake, lack of physical inactivity, stress and kidney diseases.