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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Exforge 5 mg/160 mg Tablet is an anti-hypertensive medication used to treat essential hypertension (high blood pressure) that is not adequately controlled on either amlodipine or valsartan taken alone. It contains Amlodipine (calcium channel blocker) and Valsartan (angiotensin receptor blocker). Together, amlodipine and valsartan effectively relax and widen the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

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Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Exforge 5 mg/160 mg Tablet

Exforge 5 mg/160 mg Tablet belongs to the class of 'anti-hypertensive drugs' used to treat essential hypertension (high blood pressure) that is not adequately controlled on either amlodipine or valsartan taken alone. Hypertension or high blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it leads to heart disease, irregular heartbeat, and other complications. Essential means that hypertension has no obvious cause.

Exforge 5 mg/160 mg Tablet contains Amlodipine (calcium channel blocker) and Valsartan (angiotensin receptor blocker). Together, amlodipine and valsartan effectively relax and widen the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

Exforge 5 mg/160 mg Tablet should be taken as prescribed by your doctor. In some cases, you may experience Feeling sick (nausea), being sick (vomiting), diarrhoea, headaches, flushing, feeling tired, feeling dizzy, pain in your joints or muscles, and swollen ankles. Most of these side effects of Exforge 5 mg/160 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. It is advisable to drink plenty of fluids while taking Exforge 5 mg/160 mg Tablet.

Before taking the Exforge 5 mg/160 mg Tablet, inform your doctor about all your medical conditions, sensitivities, and medications you are using. Even if you feel better, do not stop taking your medication. Exforge 5 mg/160 mg Tablet should not be used in pregnant or lactating women and the paediatric population. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Exforge 5 mg/160 mg Tablet

Treatment of Hypertension (high blood pressure)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Exforge 5 mg/160 mg Tablet contains Amlodipine (calcium channel blocker) and Valsartan (angiotensin receptor blocker). Together, Amlodipine and Valsartan effectively relax and widen your blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. It further helps to reduce the occurrence of heart attack or stroke.

How Exforge 5 mg/160 mg Tablet Works

Exforge 5 mg/160 mg Tablet contains Amlodipine (calcium channel blocker) and Valsartan (angiotensin receptor blocker). Together, amlodipine and valsartan effectively relax and widen the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Exforge 5 mg/160 mg Tablet

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Diarrhoea
  • Headaches
  • Flushing
  • Feeling tired
  • Feeling dizzy
  • Pain in your joints or muscles
  • Swollen ankles

What if I have taken an overdose of Exforge 5 mg/160 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Exforge 5 mg/160 mg Tablet may include trouble breathing due to allergic reaction, passing out, jaundice, indicating liver damage, dark urine and muscle pain, rhabdomyolysis, kidney damage, seizures, dizziness, fainting, and fast or slow heartbeat. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Exforge 5 mg/160 mg Tablet is not advised for use in pregnant and breastfeeding women. It is recommended not to take if you are allergic to any component present in Exforge 5 mg/160 mg Tablet, has severe liver problems or bile problems such as biliary cirrhosis or cholestasis, or extremely low blood pressure (hypotension), have narrowing of the aortic valve (aortic stenosis) or cardiogenic shock (a condition where your heart is unable to supply enough blood to the body). It is also recommended not to be used if you suffer from heart failure after a heart attack, have diabetes or impaired kidney function, and are treated with a blood pressure lowering medicine containing aliskiren.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
ValsartanAliskiren
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Using Exforge 5 mg/160 mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Exforge 5 mg/160 mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
ValsartanAliskiren
Critical
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Using Aliskiren together with Exforge 5 mg/160 mg Tablet may increase the risk of serious side effects (kidney problems, low blood pressure, or high potassium levels).

How to manage the interaction:
Taking Exforge 5 mg/160 mg Tablet with Aliskiren is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
AmlodipineSimvastatin
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Taking simvastatin with Exforge 5 mg/160 mg Tablet may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking Exforge 5 mg/160 mg Tablet with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipinePrimidone
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Using Exforge 5 mg/160 mg Tablet and primidone together may lower Exforge 5 mg/160 mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Exforge 5 mg/160 mg Tablet with primidone can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineTizanidine
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Co-administration of Tizanidine and Exforge 5 mg/160 mg Tablet can increase the risk or severity of developing side effects like low blood pressure.

How to manage the interaction:
Although co-administration of Exforge 5 mg/160 mg Tablet with tizanidine can result in an interaction, it can be taken when a doctor has advised it. However, if you experience headache, dizziness, palpitations, or irregular heart rate while taking these drugs, contact the doctor immediately. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not discontinue any medications without consulting the doctor.
AmlodipineLemborexant
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Coadministration of lemborexant and Exforge 5 mg/160 mg Tablet may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of Exforge 5 mg/160 mg Tablet with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.
AmlodipineItraconazole
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Coadministration of Exforge 5 mg/160 mg Tablet with itraconazole may significantly raise the blood levels and effects of Exforge 5 mg/160 mg Tablet.

How to manage the interaction:
Exforge 5 mg/160 mg Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing, dizziness or fainting, swelling of the hands, ankles, or feet, or any other of these symptoms. Without consulting a doctor, never stop taking any medication.
AmlodipineRifapentine
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Coadministration of Exforge 5 mg/160 mg Tablet and Rifapentine may significantly reduce the blood levels of Exforge 5 mg/160 mg Tablet, which may make the medication less effective.

How to manage the interaction:
There may be a possibility of interaction between Exforge 5 mg/160 mg Tablet and Rifapentine, but it can be taken if prescribed by a doctor. If you have any symptoms, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
AmlodipineEnzalutamide
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Using a combination of Exforge 5 mg/160 mg Tablet and enzalutamide may drastically lower Exforge 5 mg/160 mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Taking Exforge 5 mg/160 mg Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineMitotane
Severe
How does the drug interact with Exforge 5 mg/160 mg Tablet:
Using Exforge 5 mg/160 mg Tablet and mitotane together may drastically lower Exforge 5 mg/160 mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of Exforge 5 mg/160 mg Tablet with mitotane can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are highly antioxidants.
  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid the consumption of too much salt or salty food.
  • Keep your weight under control with a BMI of 19.5-24.9.
  • Regular physical activity or exercise like walking improves your blood flow.
  • When possible, elevate your legs or the swollen area on a chair or pillows.
  • Avoid standing or sitting for extended periods.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Exforge 5 mg/160 mg Tablet Substitute

Substitutes safety advice
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  • Trivalzaar 160 mg Tablet 10's

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    18.36per tablet
  • Valembic 160 AM Tablet 10's

    by AYUR

    8.62per tablet
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Alcohol

Caution

Do not consume alcohol along with Exforge 5 mg/160 mg Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Exforge 5 mg/160 mg Tablet is not recommended in pregnancy. This is because Valsartan can reduce the amount of amniotic fluid, especially if taken in the second and third trimesters of pregnancy.

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Breast Feeding

Unsafe

Exforge 5 mg/160 mg Tablet is not recommended for breastfeeding mothers.

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Driving

Caution

Driving after taking Exforge 5 mg/160 mg Tablet is not recommended as it may occasionally cause tiredness or dizziness.

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Liver

Caution

Exforge 5 mg/160 mg Tablet to be taken with caution, especially if you have a liver disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before taking the Exforge 5 mg/160 mg Tablet if you have a history of kidney disease. Your doctor will prescribe only if the benefits outweigh the risks. In case of moderate kidney impairment, potassium level monitoring is advisable.

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Children

Unsafe

Use of Exforge 5 mg/160 mg Tablet in children under 12 years of age is not recommended as the safety and efficacy of Exforge 5 mg/160 mg Tablet in these age groups have not yet been established.

FAQs

Exforge 5 mg/160 mg Tablet is used to treat Hypertension (high blood pressure).

Exforge 5 mg/160 mg Tablet contains Amlodipine (calcium channel blocker) and Valsartan (angiotensin receptor blocker). Together, amlodipine and valsartan effectively relax and widen your blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

You are not recommended to stop using Exforge 5 mg/160 mg Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Exforge 5 mg/160 mg Tablet for as long as your doctor has prescribed it, and if you experience any difficulty while taking Exforge 5 mg/160 mg Tablet, please consult your doctor.

If you have missed a dose of Exforge 5 mg/160 mg Tablet, you are advised to take it as soon as you remember. However, try not to miss a dose in the first place; if it's time for you to take your next dose, then do not take both doses together. Take only one dose; taking a double dose of Exforge 5 mg/160 mg Tablet will lead to low blood pressure.

Inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.

Exforge 5 mg/160 mg Tablet is restricted in people with known allergies to any of this medicine's components. It should be used with caution in people with liver impairment. It should also be avoided in women's second and third trimesters of their pregnancy.

Exforge 5 mg/160 mg Tablet can be safely taken as long as your doctor prescribes it. High blood pressure is life-long, and one should not abruptly discontinue it without discussing it with a doctor.

Yes, Exforge 5 mg/160 mg Tablet contains amlodipine, which is known to cause ankle swelling upon long-term use. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.

Before taking Exforge 5 mg/160 mg Tablet, inform your doctor about all your medical conditions and medications you are using. Let the doctor know if you are pregnant or breastfeeding. Discuss with the doctor if you have low blood pressure, heart, kidney or liver problems.

Exforge 5 mg/160 mg Tablet can be taken on an empty stomach or with food. Swallow it as a whole with water.

Take Exforge 5 mg/160 mg Tablet as advised by the doctor. To help you remember to take Exforge 5 mg/160 mg Tablet, take it at around the same time daily.

Exforge 5 mg/160 mg Tablet starts working immediately and you may notice its effects in a few weeks. Continue taking Exforge 5 mg/160 mg Tablet for the prescribed duration for full benefits.

Exforge 5 mg/160 mg Tablet may cause kidney damage in some cases. Consult the doctor if you notice signs of kidney damage such as swelling in feet, legs or ankles, unusual tiredness or weakness, chest pain, difficulty breathing, nausea, seizures, confusion, and reduced need to pee. Let the doctor know if you have kidney problems, have had a kidney transplant, have narrowing of kidney arteries, or have diabetes-related kidney problems.

Exforge 5 mg/160 mg Tablet should not be given to people who are allergic to any of its components. It is also recommended if you have severe liver problems, bile problems such as biliary cirrhosis or cholestasis, severe low blood pressure, aortic stenosis (narrowing of the aortic valve), or cardiogenic shock (a condition in which the heart is unable to supply enough blood to the body).

Exforge 5 mg/160 mg Tablet is not known to cause weight gain. If you notice any changes in weight, consult the doctor.

Exforge 5 mg/160 mg Tablet should be taken for as long as it has been prescribed by the doctor. The doctor will determine the duration of the treatment based on your condition.

Exforge 5 mg/160 mg Tablet should not be taken during pregnancy as it may harm the unborn baby. It is not recommended during breastfeeding as the medicine may pass into breast milk. Avoid consuming grapefruit and grapefruit juice while on treatment with Exforge 5 mg/160 mg Tablet.

Exforge 5 mg/160 mg Tablet may cause side effects like nausea, vomiting, diarrhoea, headaches, flushing, feeling tired, feeling dizzy, pain in your joints or muscles, and swollen ankles. Most of these side effects of Exforge 5 mg/160 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. It is advisable to drink plenty of fluids while taking Exforge 5 mg/160 mg Tablet.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - EXFO139

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